Catheter devices and methods for their use in the treatment of calcified vascular occlusions
First Claim
1. A catheter device comprising:
- first, second and third lumens, wherein at least one of said lumens is fabricated from a material sufficient for delivery of an acidic dissolution solution; and
a first vascular occlusion means.
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0 Petitions
Accused Products
Abstract
Catheter devices and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter devices include at least a first, second and third lumen, where: (a) the first lumen is used for delivery of an acidic dissolution solution to the vascular site; (b) the second lumen is used for delivery of a buffer solution to the vascular site; and (c) the third lumen is used for removal of fluid from the vascular site. In many preferred embodiments, the first, second and third lumens are coaxial. In practicing the subject methods, the vascular site is flushed simultaneously with an acidic dissolution fluid and a buffer solution, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the acidic dissolution fluid and the remainder of the vascular site is not contacted with fluid having a pH that is lower than about 4. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter devices and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.
48 Citations
33 Claims
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1. A catheter device comprising:
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first, second and third lumens, wherein at least one of said lumens is fabricated from a material sufficient for delivery of an acidic dissolution solution; and
a first vascular occlusion means. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 23, 24, 25, 26, 27, 28, 30, 31, 32, 33)
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9. A catheter device comprising:
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(a) an inner first tubular member;
(b) a middle second tubular member; and
(c) a third outer tubular member having a first vascular occlusion means;
wherein said tubular members are coaxial and are movable relative to each other, and further wherein each of said tubular members;
(i) has a proximal and distal end; and
(ii) comprises a lumen. - View Dependent Claims (10, 11, 12)
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13. A catheter system comprising:
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(a) an aspiration catheter comprising an elongated tube having an aspiration lumen ending in an open distal end and an inflatable balloon at said distal end; and
(b) a second elongated tube coaxially positioned inside of said aspiration catheter; and
(c) at least one of;
(i) a total occlusion catheter insert comprising an elongated tube having an open distal end; and
(ii) a partial occlusion catheter insert comprising an elongated tube having a sealed distal end, an inflatable balloon at said distal end and at least one infusion port proximal to said inflatable balloon;
wherein at least said total and partial occlusion catheter inserts are capable of being slidably positioned within said second elongated tube to produce an annular space at the distal end of said elongated tube through which fluid may flow. - View Dependent Claims (14, 15, 16, 17, 18, 29)
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19. A method of enhancing fluid flow through a vascular site occupied by a vascular occlusion, said method comprising:
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simultaneously flushing said vascular site with;
(i) an acidic dissolution fluid; and
(ii) a buffer solution;
for a period of time sufficient for fluid flow to be enhanced through said vascular site;
wherein said simultaneous flushing occurs in a manner such that only a surface of said vascular occlusion is contacted with said acidic dissolution fluid and the remainder of said vascular site is not contacted with solution having a pH of less than about 4;
whereby fluid flow is enhanced through said vascular site. - View Dependent Claims (20, 21, 22)
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Specification