Apparatus and method for treatment of vascular restenosis by electroporation
First Claim
Patent Images
1. An apparatus for reducing restenosis after a balloon angioplasty procedure, comprising:
- an electrical pulse generator, said generator being provided for producing a predetermined number of pulses having a predetermined voltage, current, and duration;
an intravascular catheter having proximal and distal ends and including an inflatable balloon at its distal end, said balloon having on its surface at least one electrode electrically connected to said pulse generator.
1 Assignment
0 Petitions
Accused Products
Abstract
An apparatus and a method for reducing restenosis rate after balloon angioplasty is provided. The apparatus comprises a high voltage pulse generator and an intravascular catheter with electrodes adapted for delivery of electrical pulses to the media and adventitia of the treated segment of an artery. The amplitude, duration and number of the electrical pulses applied to the artery wall are sufficient to significantly deplete the population of smooth muscle cells, exuberant proliferation of which causes restenosis. To avoid possible fibrillation, the electric pulses are delivered during periods of depolarized state of myocardium.
341 Citations
23 Claims
-
1. An apparatus for reducing restenosis after a balloon angioplasty procedure, comprising:
-
an electrical pulse generator, said generator being provided for producing a predetermined number of pulses having a predetermined voltage, current, and duration;
an intravascular catheter having proximal and distal ends and including an inflatable balloon at its distal end, said balloon having on its surface at least one electrode electrically connected to said pulse generator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
-
-
19. A method of reducing restenosis after angioplasty, comprising:
-
providing an electrical pulse generator;
providing an inflatable intravascular balloon having at least one electrode on its surface, the second electrode is provided on the same balloon or on the patient'"'"'s skin outside the body;
delivering a predetermined number of electrical pulses generated by the pulse generator to the electrodes, said pulses providing the electric field to the smooth muscle cells above the upper electroporation limit. - View Dependent Claims (20, 21, 22, 23)
-
Specification