Generation of spatially-averaged excitation-emission map in heterogeneous tissue
First Claim
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1. A method for evaluating fluorescence of a heterogeneous tissue comprising:
- exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths;
collecting emission radiation from said two-dimensional portion of the tissue surface simultaneously with excitation of said portion; and
forming a two-dimensional excitation-emission map of said excitation radiation and said simultaneously collected emission radiation and spatially averaging said excitation and emission radiation.
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Abstract
An instrument for evaluating fluorescence of a heterogeneous tissue includes means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths, means for collecting emission radiation from the two-dimensional portion of the tissue surface simultaneously with excitation of the portion, and means for forming a two-dimensional excitation-emission map of the excitation radiation and the simultaneously collected emission radiation and spatially averaging the excitation and emission radiation.
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Citations
13 Claims
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1. A method for evaluating fluorescence of a heterogeneous tissue comprising:
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exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths;
collecting emission radiation from said two-dimensional portion of the tissue surface simultaneously with excitation of said portion; and
forming a two-dimensional excitation-emission map of said excitation radiation and said simultaneously collected emission radiation and spatially averaging said excitation and emission radiation.
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2. An instrument for evaluating fluorescence of a heterogeneous tissue comprising:
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means for exciting a two-dimensional portion of the tissue surface with excitation radiation at a plurality of excitation wavelengths;
means for collecting emission radiation from said two-dimensional portion of the tissue surface simultaneously with excitation of said portion; and
means for forming a two-dimensional excitation-emission map of said excitation radiation and said simultaneously collected emission radiation and spatially averaging said excitation and emission radiation.
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3. A method of rapidly gathering UV and visible fluorescence spectra in vivo spatially averaged over tissue, said method comprising the steps of:
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illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths;
collecting emission radiation simultaneously from said strips of tissue with the step of illuminating with said plurality of excitation wavelengths; and
disposing said emission radiation onto a two-dimensional array of detector elements, wherein said two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in said map are collected at once.
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4. An instrument for rapidly gathering UV and visible fluorescence spectra in vivo spatially averaged over tissue, said method comprising:
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means for illuminating strips of tissue with excitation radiation simultaneously at a plurality of excitation wavelengths;
means for collecting emission radiation simultaneously from said strips of tissue with the step of illuminating with said plurality of excitation wavelengths; and
means for disposing said emission radiation onto a two-dimensional array of detector elements, wherein said two-dimensional detector disposition is arranged by wavelength to form a two-dimensional excitation-emission map, in which all elements in said map are collected at once.
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5. A common fiber optic head comprising:
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a plurality of excitation fiber optic bundles, wherein each excitation fiber optic bundle comprises one or more excitation fibers;
a plurality of emission fiber optic bundles, wherein each emission fiber optic bundle comprises one or more emission fibers; and
wherein distal ends of said fiber optic bundles are disposed in a two-dimensional array. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13)
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Specification