METHODS FOR DELIVERING BIOACTIVE AGENTS
First Claim
1. A method for enhancing the bioavailability of a bioactive agent in vivo comprising (i) administering said bioactive agent to a patient, (ii) administering a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers to the patient, and (iii) applying ultrasonic energy to the patient in an amount sufficient to produce cavitation of said vesicles, wherein said vesicle composition is administered to said patient at a rate which comprises continuous infusion.
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Accused Products
Abstract
Methods for enhancing the bioavailability of a bioactive agent in vivo. Embodiments of the invention involve administering a bioactive agent and an acoustically active composition to a patient. Ultrasound energy may be applied in an amount sufficient to activate the acoustically active composition. In preferred form, the acoustically active composition is administered to the patient at a rate which comprises continuous infusion.
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Citations
74 Claims
- 1. A method for enhancing the bioavailability of a bioactive agent in vivo comprising (i) administering said bioactive agent to a patient, (ii) administering a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers to the patient, and (iii) applying ultrasonic energy to the patient in an amount sufficient to produce cavitation of said vesicles, wherein said vesicle composition is administered to said patient at a rate which comprises continuous infusion.
- 49. A method of enhancing the delivery of a bioactive agent in tissue in vivo comprising (i) administering said bioactive agent to a patient, (ii) administering an acoustically active composition to said patient, and (iii) applying ultrasonic energy to said tissue in an amount sufficient to activate said acoustically active composition, wherein said acoustically active composition is administered to said patient at a rate which comprises continuous infusion.
- 63. A method for lysing a thrombus comprising (i) administering a thrombolytic agent to a patient, (ii) administering a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers to the patient, and (iii) applying ultrasonic energy to the thrombus in an amount sufficient to produce cavitation of said vesicles, wherein said vesicle composition is administered to said patient at a rate which comprises continuous infusion.
Specification