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Axin domain-like polypeptide inhibitors of glycogen synthase kinase 3 beta activity and activators of wnt signaling

  • US 20010052137A1
  • Filed: 03/01/2001
  • Published: 12/13/2001
  • Est. Priority Date: 03/01/2000
  • Status: Abandoned Application
First Claim
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1. A composition that inhibits glycogen synthase kinase 3 beta activity, the composition comprising a polypeptide of not more than about 60 amino acid residues, the polypeptide having an amino acid sequence which comprises the sequence Val-Xaa5-Pro-Xaa7-Xaa8-Phe-Ala-Xaa11-Glu-Leu-Ile-Xaa15-Arg-Leu-Glu-Xaa19-Xaa20-Xaa21-Xaa22-Xaa23-Xaa24-Glu, wherein each of Xaa7, Xaa8, Xaa11, and Xaa19 is independently any amino acid residue, Xaa5 is a negatively-charged amino acid residue, Xaa15 is a polar amino acid residue, Xaa20 is a non-polar aliphatic amino acid residue, and at least two of Xaa21, Xaa22, Xaa23, Xaa24 are polar amino acid residues, the balance of Xaa21, Xaa22, Xaa23, Xaa24 being any amino acid residue.

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