Method for analyzing amount of activity

• US 20010053870A1
• Filed: 02/16/2001
• Published: 12/20/2001
• Est. Priority Date: 07/23/1999
• Status: Active Grant

• Current Assignee: Nucletron Operations BV
• Original Assignee: Nucletron Holding BV (New Nucletron Company BV)
• Inventors: Kindlein, Johann (Hans), Visscher, Arie Luite, Loffler, Edgar German, Breemer, Jan D.
• Granted Patent: US 6,595,908 B2
• Time in Patent Office: Days
• US Class Current: 600/7
• CPC Class Codes: A61N 2005/1008 Apparatus for temporary insertion of sources, e.g. afterloaders
• CPC Class Codes: A61N 2005/1009 Apparatus for loading seeds into magazines or needles
• CPC Class Codes: A61N 2005/1011 Apparatus for permanent insertion of sources
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

A modular device for implanting radioactive seeds in an animal body through needles implanted in the body. Trains of radioactive seeds and non-radioactive spacers are assembled in an assembly unit. The assembly unit comprises means for determining activity of the seeds with an accuracy that allows distinguishing between different activities within tolerance ranges of specified nominal activities for the seeds. After implantation of the seeds in the body a pre-plan may be recalculated taking into consideration actual activities of seeds implanted. Not correctly comprosed trains may be disposed of. A post-plan may be determined based upon actually measured activities of implanted seeds.

Claims

1. Method for analyzing amount of activity due to radioactive seeds having specified activities and that are to be implanted in animal tissue comprising the steps of:

determining a pre-plan comprising determining a desired distribution of implanted of said radioactive seeds and non-radioactive spacers in said tissue;

in accordance with said pre-plan assembling trains of said radioactive seeds and said spacers for implantation;

accurately determining radiation activity of each seed while adding such seed to a said train with an accuracy that allows distinguishing between different activities within tolerance ranges of said specified activities for such seed.

2. Method according to

claim 1

, said method further comprising the step of:

recalculating said pre-plan using accurately determined activities.

3. Method according to

claim 2

, in which the step of using accurately determined activities comprises determining and using an average value of said accurately determined activities.

4. Method according to

claim 1

, said method further comprising the steps of:

determining actual locations of said seeds after implant; and

recalculating said pre-plan using both actual locations and accurately determined activities.

5. Method according to

claim 4

, in which the step of using accurately determined activities comprises determining and using an average value of said accurately determined activities.

6. Method for implanting radioactive seeds in animal tissue comprising the steps of:

analyzing amount of activity according to

claim 1

;

implanting unloaded needles in said tissue;

assembling said trains outside said implanted unloaded needles in an assembly unit;

connecting said assembly unit to a said implanted unloaded needle before, during or after assembling a said train for such needle;

transferring said assembled train from said assembly unit to said implanted unloaded needle; and

implanting said transferred assembled train in said animal tissue.

7. Method according to

claim 6

, said method further comprising the step of:

recalculating said pre-plan using accurately determined activities.

8. Method according to

claim 7

, in which the step of using accurately determined activities comprises determining and using an average value of said accurately determined activities.

9. Method according to

claim 6

, said method further comprising the steps of:

determining actual locations of said seeds after implant; and

recalculating said pre-plan using both actual locations and accurately determined activities.

10. Method according to

claim 9

, in which the step of using accurately determined activities comprises determining and using an average value of said accurately determined activities.

11. Method according to

claim 6

, said method further comprising the step of:

during or after assembly and before transfer of a said train checking for correct composition of said train.

12. Method according to

claim 11

, said method further comprising the steps of;

providing a container for radioactive materials; and

in case of a non-correct composition of a said train connecting said assembly unit to said container; and

disposing of said not correctly composed train in said container.

13. Method according to

claim 1

, said method further comprising the steps of:

providing a calibrating device for radiation activity levels;

providing a measuring device for carrying out the step of determining activity of each seed while adding such seed to a train;

calibrating said measuring device against said calibrating device before carrying out the step of determining activity of each seed while adding such seed to a train.

14. Method according to

claim 13

, said step of providing a calibrating device comprising a step of providing a calibrating device for absolute radiation activity levels.

15. Method for implanting radioactive seeds having specified activities in animal tissue comprising the steps of:

determining a pre-plan comprising determining a desired distribution of implanted radioactive seeds and non-radioactive spacers in said tissue;

in accordance with said pre-plan assembling trains of seeds and spacers for implantation;

determining radiation activity of each seed while adding such seed to a said train;

implanting unloaded needles in said tissue;

assembling said trains outside said implanted unloaded needles in an assembly unit;

connecting said assembly unit to a said implanted unloaded needle before, during or after assembling a said train for such needle;

transferring said assembled train from said assembly unit to said implanted unloaded needle;

implanting said transferred assembled train in said animal tissue.

16. Method according to

claim 15

, said method further comprising the step of:

recalculating said pre-plan using determined activities.

17. Method according to

claim 16

, in which the step of using determined activities comprises determining and using an average value of said determined activities.

18. Method according to

claim 15

, said method further comprising the steps of:

determining actual locations of said seeds after implant; and

recalculating said pre-plan using both actual locations and determined activities.

19. Method according to

claim 18

, in which the step of using determined activities comprises determining and using an average value of said determined activities.

20. Method according to

claim 15

, said method further comprising the step of:

during or after assembly and before transfer of a said train checking for correct composition of said train being assembled.

21. Method according to

claim 20

, said method further comprising the steps of;

providing a container for radioactive materials; and

in case of a non-correct composition of a said train connecting said assembly unit to said container; and

disposing of said not correctly composed train in said container.

22. Method according

claim 15

, said method further comprising the steps of:

providing a calibrating device for radiation activity levels;

providing a measuring device for carrying out the step of determining activity of each seed while adding such seed to a train;

calibrating said measuring device against said calibrating device before carrying out the step of determining activity of each seed while adding such seed to a train.

23. Method according to

claim 22

, said step of providing a calibrating device comprising a step of providing a calibrating device for absolute radiation activity levels.

26. Method for determining a post-plan for radiation treatment of animal tissue with radioactive seeds having specified activities, said method comprising:

implanting said seeds according to

claim 15

;

recalculating said pre-plan using determined activities;

determining said post-plan based upon said recalculated pre-plan.

27. Method according to

claim 26

, in which the step of using determined activities in recalculating said pre-plan comprises determining and using an average value of said determined activities.

24. Method for determining a post-plan for radiation treatment of animal tissue, said method comprising:

determining a pre-plan for radiation treatment of said animal tissue based upon specified activities of to be implanted radioactive seeds;

in accordance with said pre-plan assembling trains of said seeds and spacers for implantation;

determining radiation activity of each seed while adding such seed to a said train;

determining said post-plan using determined radiation activities.

25. Method according to

claim 24

, in which the step of using determined activities comprises using an average value of said determined activities.