DEVICES AND METHOD FOR USING CENTRIPETAL ACCELERATION TO DRIVE FLUID MOVEMENT IN A MICROFLUIDICS SYSTEM WITH ON-BOARD INFORMATICS
First Claim
1. A centripetally-motivated fluid micromanipulation apparatus that is a combination of a microsystem platform, comprising a substrate having a first flat, planar surface and a second flat, planar surface opposite thereto, wherein the first surface comprises a multiplicity of microchannels embedded therein and a sample input means, wherein the sample input means and the microchannels are connected and in fluidic contact, and wherein the second flat, planar surface opposite to the first flat planar surface of the platform is encoded with an eletromagnetically-readable instruction set for controlling rotational speed, duration, or direction of the platform, and a micromanipulation device, comprising a base, a rotating means, a power supply and user interface and operations controlling means, wherein the rotating means is operatively linked to the microsystem platform and in rotational contact therewith wherein a volume of a fluid within the microchannels of the platform is moved through said microchannels by centripetal force arising from rotational motion of the platform for a time and a rotational velocity sufficient to move the fluid through the microchannels.
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Abstract
This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The microsystem platforms of the invention are also provided having system informatics and data acquisition, analysis and storage and retrieval informatics encoded on the surface of the disk opposite to the surface containing the fluidic components. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.
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Citations
84 Claims
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1. A centripetally-motivated fluid micromanipulation apparatus that is a combination of
a microsystem platform, comprising a substrate having a first flat, planar surface and a second flat, planar surface opposite thereto, wherein the first surface comprises a multiplicity of microchannels embedded therein and a sample input means, wherein the sample input means and the microchannels are connected and in fluidic contact, and wherein the second flat, planar surface opposite to the first flat planar surface of the platform is encoded with an eletromagnetically-readable instruction set for controlling rotational speed, duration, or direction of the platform, and a micromanipulation device, comprising a base, a rotating means, a power supply and user interface and operations controlling means, wherein the rotating means is operatively linked to the microsystem platform and in rotational contact therewith wherein a volume of a fluid within the microchannels of the platform is moved through said microchannels by centripetal force arising from rotational motion of the platform for a time and a rotational velocity sufficient to move the fluid through the microchannels.
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2. A centripetally-motivated fluid micromanipulation apparatus that is a combination of
a microsystem platform, comprising a substrate having a first flat, planar surface and a second flat, planar surface opposite thereto, wherein the first surface comprises a multiplicity of microchannels, a reaction chamber and a reagent reservoir embedded therein, and a sample input means, wherein the sample input means, the microchannels, the reaction chamber and the reagent reservoir are connected and in fluidic contact, and wherein the second flat, planar surface opposite to the first flat planar surface of the platform is encoded with an eletromagnetically-readable instruction set for controlling rotational speed, duration, or direction of the platform, and a micromanipulation device, comprising a base, a rotating means, a power supply and user interface and operations controlling means, wherein the rotating means is operatively linked to the microsystem platform and in rotational contact therewith wherein a volume of a fluid within the microchannels of the platform is moved through said microchannels by centripetal force arising from rotational motion of the platform for a time and a rotational velocity sufficient to move the fluid through the microchannels.
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3. A centripetally-motivated fluid micromanipulation apparatus that is a combination of
a microsystem platform, comprising a substrate having a first flat, planar surface and a second flat, planar surface opposite thereto, wherein the first surface comprises a multiplicity of microchannels, a reaction chamber and a reagent reservoir embedded therein and a sample input means, wherein the sample input means, the microchannels, the reaction chamber and the reagent reservoir are connected and in fluidic contact, and wherein fluid motion from the microchannels, the reaction chamber and the reagent reservoir is controlled by microvalves connected thereto, and wherein the second flat, planar surface opposite to the first flat planar surface of the platform is encoded with an eletromagnetically-readable instruction set for controlling rotational speed, duration, or direction of the platform, and a micromanipulation device, comprising a base, a rotating means, a power supply and user interface and operations controlling means, wherein the rotating means is operatively linked to the microsystem platform and in rotational contact therewith wherein a volume of a fluid within the microchannels of the platform is moved through said microchannels by centripetal force arising from rotational motion of the platform for a time and a rotational velocity sufficient to move the fluid through the microchannels.
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10. The apparatus of
claim 10 , wherein the microsystem platform has a thickness of about 0.1 to 100 mm, and wherein the cross-sectional dimension of the reaction chamber or the reagent reservoir between the first and second flat, planar surfaces is from 1 to 75 percent of said thickness of the platform.
Specification