Effect of electric field and ultrasound for transdermal drug delivery
First Claim
1. A method for enhancing transdermal transport of compounds comprising administering to the skin an effective amount of ultrasound in combination with an electric field.
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Abstract
Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by application of an electric field, for example, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layers of the stratum corneum (SC). This method provides higher drug transdermal fluxes, allows rapid control of transdermal fluxes, and allows drug delivery or analyte extraction at lower ultrasound intensities than when ultrasound is applied in the absence of an electric field.
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Citations
12 Claims
- 1. A method for enhancing transdermal transport of compounds comprising administering to the skin an effective amount of ultrasound in combination with an electric field.
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12. An apparatus for applying ultrasound and an electric field to skin in an amount effect to enhance transport of molecules through the skin without damaging the skin.
Specification