Compositions for the delivery of antigens
First Claim
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1. A composition comprising:
- (a) an antigen;
(b) an adjuvant;
(c) at least one carrier comprising a member selected from the groups consisting of;
(i) an acylated amino acid or a salt thereof;
(ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
(iii) a sulfonated amino acid or a salt thereof;
(iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
or (v) any combination thereof.
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Accused Products
Abstract
The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.
27 Citations
22 Claims
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1. A composition comprising:
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(a) an antigen;
(b) an adjuvant;
(c) at least one carrier comprising a member selected from the groups consisting of;
(i) an acylated amino acid or a salt thereof;
(ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
(iii) a sulfonated amino acid or a salt thereof;
(iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
or(v) any combination thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 14, 15, 16, 18)
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11. A composition comprising:
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(a) ovalbumin;
(b) cholera toxin; and
(c) at least one carrier comprising a member selected from the groups consisting of;
(i) an acylated amino acid or a salt thereof;
(ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
(iii) a sulfonated amino acid or a salt thereof;
(iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
or(v) any combination thereof.
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12. A composition comprising:
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(a) Infectious Bursal Disease Virus;
(b) cholera toxin;
(c) cholera toxin β
-subunit; and
(d) at least one carrier comprising a member selected from the groups consisting of;
(i) an acylated amino acid or a salt thereof;
(ii) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
(iii) a sulfonated amino acid or a salt thereof;
(iv) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
or(v) any combination thereof. - View Dependent Claims (13, 17, 21, 22)
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19. A method for preparing microspheres, said method comprising:
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(A) solubilizing, in a solvent, at least one carrier to provide a carrier solution; and
(B) contacting said carrier solution with an antigen, an adjuvant, and a precipitator solution in which said carrier is insoluble;
wherein said carrier comprises a member selected from the groups consisting of;
(a) an acylated amino acid or a salt thereof;
(b) a poly amino acid comprising at least one acylated amino acid or a salt thereof;
(c) a sulfonated amino acid or a salt thereof;
(d) a poly amino acid comprising at least one sulfonated amino acid or a salt thereof;
or(e) any combination thereof. - View Dependent Claims (20)
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Specification