Multi-format sample processing devices, methods and systems
First Claim
1. A sample processing device comprising:
- a rectangular body comprising a pair of opposing major surfaces and a center, a first portion, and a second portion, wherein the first portion and the second portion are located on opposite sides of the center;
a plurality of first process arrays located within the first portion of the body, each of the first process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of process arrays are arranged in a circular arc about the center of the body; and
a plurality of second process arrays located within the second portion of the body, each of the second process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of second process arrays are arranged in a circular arc about the center of the body.
1 Assignment
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Accused Products
Abstract
Devices, methods, and systems for processing sample materials are disclosed. The present invention may provide a bridge between standard microtiter plate systems, methods, protocols, etc. (that include wells arranged in rectangular arrays) and rotating sample processing devices and systems that allow users to obtain the rapid processing advantages of the more advanced sample processing devices. The sample processing devices preferably include a rectangular body to improve compatibility of the sample processing devices of the present invention with equipment designed for use with more conventional microtiter plates (which are typically rectangular in shape). The sample processing devices also include at least one set of process chambers arranged in one or more circular arcs and may include input and/or output chambers arranged in a rectilinear grid array.
165 Citations
59 Claims
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1. A sample processing device comprising:
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a rectangular body comprising a pair of opposing major surfaces and a center, a first portion, and a second portion, wherein the first portion and the second portion are located on opposite sides of the center;
a plurality of first process arrays located within the first portion of the body, each of the first process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of process arrays are arranged in a circular arc about the center of the body; and
a plurality of second process arrays located within the second portion of the body, each of the second process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of second process arrays are arranged in a circular arc about the center of the body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A sample processing device comprising:
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a rectangular body comprising a center, a first portion, and a second portion, wherein the first portion and the second portion are located on opposite sides of the center;
a plurality of first process arrays located within the first portion of the body, each of the first process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of process arrays are arranged in a circular arc about the center of the body; and
a plurality of second process arrays located within the second portion of the body, each of the second process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of second process arrays are arranged in a circular arc about the center of the body;
wherein the input chambers of the plurality of first process arrays and the input chambers of the plurality of second process arrays are arranged in rectilinear grid array;
and wherein the output chambers of the first process arrays of the plurality of first process arrays are arranged in a rectilinear grid array, and further wherein the output chambers of the second process arrays of the plurality of second process arrays are arranged in a rectilinear grid array. - View Dependent Claims (11, 12, 13, 14, 15)
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16. A sample processing device comprising:
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a body comprising a center, a first portion, and a second portion, wherein the first portion and the second portion are located on opposite sides of the center;
a plurality of first process arrays located within the first portion of the body, each of the first process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of process arrays are arranged in a circular arc about the center of the body, and further wherein the output chambers of the plurality of first process arrays are arranged in a rectilinear grid array; and
a plurality of second process arrays located within the second portion of the body, each of the second process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of second process arrays are arranged in a circular arc about the center of the body, and further wherein the output chambers of the plurality of second process arrays are arranged in a rectilinear grid array. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23)
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24. A sample processing device comprising:
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a body comprising a center, a first portion, and a second portion, wherein the first portion and the second portion are located on opposite sides of the center;
a plurality of first process arrays located within the first portion of the body, each of the first process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of process arrays are arranged in a circular arc about the center of the body, and further wherein the input chambers of the plurality of first process arrays are arranged in a rectilinear grid array; and
a plurality of second process arrays located within the second portion of the body, each of the second process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of second process arrays are arranged in a circular arc about the center of the body, and further wherein the input chambers of the plurality of second process arrays are arranged in a rectilinear grid array. - View Dependent Claims (25, 26, 27, 28, 29)
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30. A sample processing device comprising:
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a rectangular body; and
a plurality of first process arrays located within the body, each of the first process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of process arrays are arranged in a circular arc;
wherein the input chambers of the plurality of first process arrays are arranged in rectilinear grid array. - View Dependent Claims (31, 32, 33, 34)
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35. A method of using a sample processing device, the method comprising:
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providing a sample processing device that comprises a rectangular body comprising a pair of opposing major surfaces and a center, a first portion, and a second portion, wherein the first portion and the second portion are located on opposite sides of the center;
a plurality of first process arrays located within the first portion of the body, each of the first process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of process arrays are arranged in a circular arc about the center of the body; and
a plurality of second process arrays located within the second portion of the body, each of the second process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of second process arrays are arranged in a circular arc about the center of the body;
loading sample material in the input chambers of at least some of the first and second process arrays; and
transporting the sample material from the input chambers to at least some of the primary process chambers by rotating the sample processing device about an axis of rotation extending through the center of the body, wherein the primary process chambers are located further from the axis of rotation than the input chambers. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42)
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43. A method of using a sample processing device, the method comprising:
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providing a sample processing device that comprises a body comprising a center, a first portion, and a second portion, wherein the first portion and the second portion are located on opposite sides of the center;
a plurality of first process arrays located within the first portion of the body, each of the first process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of process arrays are arranged in a circular arc about the center of the body, and further wherein the output chambers of the plurality of first process arrays are arranged in a rectilinear grid array; and
a plurality of second process arrays located within the second portion of the body, each of the second process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of second process arrays are arranged in a circular arc about the center of the body, and further wherein the output chambers of the plurality of second process arrays are arranged in a rectilinear grid array;
loading sample material in the input chambers of at least some of the first and second process arrays; and
transporting the sample material from the input chambers to at least some of the primary process chambers by rotating the sample processing device about an axis of rotation extending through the center of the body, wherein the primary process chambers are located further from the axis of rotation than the input chambers. - View Dependent Claims (44, 45, 46, 47)
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48. A method of using a sample processing device, the method comprising:
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providing a sample processing device that comprises a body comprising a center, a first portion, and a second portion, wherein the first portion and the second portion are located on opposite sides of the center;
a plurality of first process arrays located within the first portion of the body, each of the first process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of process arrays are arranged in a circular arc about the center of the body, and further wherein the input chambers of the plurality of first process arrays are arranged in a rectilinear grid array; and
a plurality of second process arrays located within the second portion of the body, each of the second process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of second process arrays are arranged in a circular arc about the center of the body, and further wherein the input chambers of the plurality of second process arrays are arranged in a rectilinear grid array;
loading sample material in the input chambers of at least some of the first and second process arrays; and
transporting the sample material from the input chambers to at least some of the primary process chambers by rotating the sample processing device about an axis of rotation extending through the center of the body, wherein the primary process chambers are located further from the axis of rotation than the input chambers. - View Dependent Claims (49, 50, 51, 52)
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53. A method of using a sample processing device, the method comprising:
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providing a sample processing device that comprises a rectangular body and a plurality of first process arrays located within the body, each of the first process arrays comprising an input chamber, an output chamber, and a primary process chamber located between the input chamber and the output chamber, wherein the primary process chambers of the plurality of process arrays are arranged in a circular arc, wherein the input chambers of the plurality of first process arrays are arranged in rectilinear grid array;
loading sample material in the input chambers of at least some of the first process arrays; and
transporting the sample material from the input chambers to at least some of the primary process chambers by rotating the sample processing device about an axis of rotation located outside of the body, wherein the primary process chambers are located further from the axis of rotation than the input chambers. - View Dependent Claims (54, 55, 56, 57, 58, 59)
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Specification