Optical measurements of bone composition
First Claim
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1. A method for detecting a bone disease in a test subject, comprising the steps of:
- transmitting radiant energy to surface of skin overlaying a bone in the test subject;
detecting radiant energy reflected from said skin surface to obtain Raman spectra, wherein the Raman spectra from the skin surface reflect the spectral information on the bone, wherein said spectral information on the bone reflects biochemical compositions of said bone; and
comparing the biochemical compositions of the test bone with those of a normal bone, wherein if the biochemical compositions of the test bone differ from those of the normal bone, the test subject might have a diseased bone.
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Abstract
The present invention provides an non-invasive and inexpensive method and/or device for detecting a disease in a bone or other tissues using an optical fiber based Raman spectrometer by detecting biochemical changes in the bone or the other tissues.
26 Citations
12 Claims
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1. A method for detecting a bone disease in a test subject, comprising the steps of:
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transmitting radiant energy to surface of skin overlaying a bone in the test subject;
detecting radiant energy reflected from said skin surface to obtain Raman spectra, wherein the Raman spectra from the skin surface reflect the spectral information on the bone, wherein said spectral information on the bone reflects biochemical compositions of said bone; and
comparing the biochemical compositions of the test bone with those of a normal bone, wherein if the biochemical compositions of the test bone differ from those of the normal bone, the test subject might have a diseased bone. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A device for detecting a bone disease, comprising:
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a source for producing radiant energy;
an applicator for transmitting radiant energy;
a means for detecting reflected radiant energy; and
a Raman spectrometer. - View Dependent Claims (9, 10)
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11. A method for detecting a disease in a test subject, comprising the steps of:
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transmitting radiant energy to surface of skin overlaying a tissue of interest in the test subject;
detecting radiant energy reflected from said skin surface to obtain Raman spectra, wherein the Raman spectra from the skin surface reflect the spectral information on the tissue, wherein said spectral information on the tissue reflects biochemical compositions of said tissue;
comparing the biochemical compositions of the test tissue with those of a normal tissue, wherein if the biochemical compositions of the test tissue differ from those of the normal tissue, the test subject might have a disease. - View Dependent Claims (12)
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Specification