Systems and methods for delivering drugs to selected locations within the body
First Claim
1. A system for delivering a drug towards a tissue region within a patient'"'"'s body, the system comprising:
- a catheter having a proximal portion and a distal portion adapted for insertion into a blood vessel, and defining a periphery and a longitudinal axis;
an orientation element on the distal portion in a predetermined circumferential relationship with the periphery of the catheter for providing a peripheral orientation of the distal portion about the longitudinal axis; and
a drug delivery element on the distal portion for delivering a drug in a predetermined direction with respect to the longitudinal axis, the drug delivery element being aligned with the peripheral orientation of the orientation element.
1 Assignment
0 Petitions
Accused Products
Abstract
A transvascular system (10) for delivering a drug to a tissue region from a blood vessel, such as a coronary vein, includes a catheter (12) having a distal portion (26) with puncturing (14), orientation (16), drug delivery (62), and imaging elements (18). The puncturing element (14) is deployable for penetrating the vessel wall to access the tissue region. The orientation element (16), e.g. a “cage” including a plurality of struts (38) (40) and/or a radiopaque marker, has a predetermined relationship with the puncturing element (14), the imaging element (18) detecting the location of the orientation element (16) with respect to the tissue region to orient the puncturing element. The catheter (12) is percutaneously introducing into the vessel, the puncturing element (14) is oriented towards the tissue region, the puncturing element (14) is deployed to access the tissue region, and the drug is delivered to the tissue region. An ablation device (230) may also be deployed to create a cavity in the tissue region for receiving the drug therein, or an indwelling catheter (214) may be advanced into and left in the tissue region. An implantable reservoir device (400) is also disclosed, including an enclosed membrane (408) on an expandable frame (402) that defines a reservoir (410) and includes a porous region (418). The reservoir device (400) may be deployed and expanded within a blood vessel, and may be filled in situ or prefilled with a drug that passes through the porous region (418). Alternatively, a pair of expandable endovascular blockers (500) may be used to isolate a section of a blood vessel which may be filled with a drug that may be absorbed by the surrounding tissue.
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Citations
84 Claims
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1. A system for delivering a drug towards a tissue region within a patient'"'"'s body, the system comprising:
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a catheter having a proximal portion and a distal portion adapted for insertion into a blood vessel, and defining a periphery and a longitudinal axis;
an orientation element on the distal portion in a predetermined circumferential relationship with the periphery of the catheter for providing a peripheral orientation of the distal portion about the longitudinal axis; and
a drug delivery element on the distal portion for delivering a drug in a predetermined direction with respect to the longitudinal axis, the drug delivery element being aligned with the peripheral orientation of the orientation element. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A system for delivering a drug to a tissue region within a patient'"'"'s body, the system comprising:
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a catheter having a proximal portion and a distal portion adapted for insertion into a blood vessel, and defining a periphery and a longitudinal axis;
a puncturing element deployable from the distal portion in a predetermined circumferential relationship with the periphery of the catheter, and including a distal tip adapted to penetrate a wall of a blood vessel to access a tissue region beyond the wall of the blood vessel;
a drug delivery element on the distal portion for delivering a drug to the tissue region; and
an orientation element on the distal portion in a predetermined relationship with the periphery of the catheter and the puncturing element. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A system for delivering a drug to a tissue region within a patient'"'"'s body, the system comprising:
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a catheter having a proximal portion and a distal portion adapted for insertion into a blood vessel, and defining a periphery and a longitudinal axis;
a needle deployable from the distal portion having a drug delivery lumen therein for delivering drugs therethrough;
an orientation element on the distal portion in a predetermined relationship with the needle; and
an imaging element adjacent the orientation element for detecting the location of the orientation element with respect to a tissue region surrounding the distal portion. - View Dependent Claims (34, 35, 36, 37, 38)
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39. A system for creating a reservoir in a tissue region within a patient'"'"'s body for receiving a drug therein, the system comprising:
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a catheter having a proximal portion and a distal portion adapted for insertion into a blood vessel, and defining a periphery and a longitudinal axis;
a guide wire assembly deployable from the distal portion in a predetermined circumferential relationship with the periphery of the catheter;
an orientation element on the distal portion in a predetermined relationship with the guide wire assembly, the orientation element being detectable by an imaging element for detecting the location of the orientation element with respect to an extravascular tissue region surrounding the distal portion; and
a tissue ablation device deployable in combination with the guide wire assembly for forming a cavity in the extravascular tissue region. - View Dependent Claims (40)
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41. A reservoir device for providing sustained delivery of a drug within the cardiovascular system of a patient, comprising:
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an elongate frame adapted to expand between a collapsed condition for insertion into a blood vessel and an enlarged condition for engaging a wall of the blood vessel, the frame defining a longitudinal axis and a periphery; and
a flexible membrane attached to the frame and defining a reservoir therein, the membrane including a porous region. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50)
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51. A method of delivering a selected to a selected tissue region within a patient'"'"'s body with a catheter having a deployable puncturing element, a drug delivery element and an orientation element on a distal portion thereof, the method comprising:
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percutaneously introducing the distal portion of the catheter into a blood vessel;
directing the distal portion endovascularly to a vessel location adjacent to the selected tissue region;
orienting the puncturing element towards the selected tissue region;
deploying the puncturing element to access the selected tissue region; and
delivering a drug with the drug delivery element to the selected tissue region. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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66. A method of creating a fluid reservoir within an extravascular tissue region for sustained delivery of a drug using a catheter having a guide wire and an orientation element on a distal portion thereof, the method comprising the steps of:
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percutaneously introducing the distal portion of the catheter into a blood vessel;
directing the distal portion endovascularly to a vessel location adjacent to the tissue region;
orienting the guide wire towards the tissue region;
deploying the guide wire into the tissue region; and
forming a drug reservoir within the tissue region. - View Dependent Claims (67, 68, 69, 70, 71, 72)
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73. A method for creating a drug reservoir within a blood vessel for delivering a drug to a tissue region adjacent the blood vessel, the method comprising the steps of:
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advancing a first endovascular blocker in a collapsed condition along the blood vessel to a location adjacent the tissue region;
expanding the first endovascular blocker to an enlarged condition, thereby sealing the blood vessel at the location from fluid flow along the blood vessel;
advancing a second endovascular blocker in a collapsed condition along the blood vessel to the location;
expanding the second endovascular blocker to an enlarged condition, thereby further sealing the blood vessel at the location from fluid flow along the blood vessel; and
introducing a drug into the blood vessel adjacent the first endovascular blocker. - View Dependent Claims (74, 75, 76, 77)
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78. A method of providing access to a selected tissue region within a patient'"'"'s body from a blood vessel using a transvascular catheter having a deployable puncturing element, and an orientation element on a distal portion thereof, the method comprising:
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percutaneously introducing the distal portion of the transvascular catheter into a blood vessel;
directing the distal portion endovascularly to a vessel location adjacent to the selected tissue region;
orienting the puncturing element towards the selected tissue region;
deploying the puncturing element to access the selected tissue region;
advancing a floppy catheter into the selected tissue region; and
removing the transvascular catheter from the body. - View Dependent Claims (79, 80, 81, 82, 83, 84)
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Specification