Method and composition for treating mammalian nasal and sinus diseases caused by inflammatory response

• US 20020006961A1
• Filed: 05/01/2001
• Published: 01/17/2002
• Est. Priority Date: 05/14/1999
• Status: Abandoned Application

• Current Assignee: Cellular Sciences Incorporated
• Original Assignee: Cellular Sciences Incorporated
• Inventors: Martin, Alain, Katz, Stanley E.
• Application Number:
  US09/846,722
• Publication Number:
  US 20020006961A1
• Time in Patent Office: Days
• US Class Current: 514/625
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/4164 1,3-Diazoles
• CPC Class Codes: A61K 9/0043 Nose

Abstract

A method for treating the disease state in mammals caused by mammalian nasal and sinus cells involved in the inflammatory response is disclosed. Mammalian nasal and sinus cells participating in the inflammatory response are contacted with an inflammatory response mediator which reduces the undesired inflammatory response and is an antioxidant. The inflammatory response mediator may further provide a cellular energy source and be a building block in the cellular synthesis of other cellular components. Compositions for reducing and treating undesired inflammatory response are also disclosed.

Claims

19. A nasal solution, comprising:

a) water,

b) sodium chloride, 0.65 % by weight,

c) pyruvate, at least 0.1 mM,

d) buffer, and optionally

e) a preservative.

wherein the nasal moisturizing saline solution is buffered and made isotonic.

20. The nasal solution of claim 19, wherein the pyruvate is present in the solution at a concentration between from about 0.1 mM to about 10 mM.

21. The nasal solution of claim 19, wherein the pyruvate is present in the solution at a concentration between from about 0.5 mM to about 10 mM.

22. The nasal solution of claim 19, wherein the buffer is selected from the group consisting of sodium bicarbonate, disodium phosphate/sodium phosphate, and monobasic potassium phosphate/sodium hydroxide.

23. The nasal solution of claim 19, wherein the preservative is selected from the group consisting of phenylcarbinol, benzalkonium chloride, and thimerosal.

24. The nasal solution of claim 19, wherein the pyruvate is present in the solution at a concentration of about 5 mM, the buffer is sodium bicarbonate.

25. The nasal solution of claim 19 further comprising a therapeutic agent wherein the therapeutic agent is one or more agents selected from the group consisting of antibacterials, antivirals, antifungals, antihistamines, proteins, enzymes, hormones, nonsteroidal anti-inflammatories, cytokines, insulin, vitamins and steroids.

27. A method for the prevention and/or treatment of rhinitis, eosinophilia syndrome, sinusitis and related conditions associated with nasal congestion, comprising administering a nasal solution to the nostrils of a patient in need thereof, wherein the nasal moisturizing saline solution comprises:

a) water,

b) sodium chloride, 0.65% by weight,

c) pyruvate, at least 0.1 mM,

d) buffer, and optionally

e) a preservative.

wherein the nasal moisturizing saline solution is buffered and made isotonic.

1. A method for treating the disease state in mammals caused by mammalian nasal and sinus cells involved in the inflammatory response comprising:

contacting the mammalian nasal and sinus cells with an inflammatory mediator;

wherein the inflammatory mediator is present in an amount capable of reducing the undesired inflammatory response and is an antioxidant.

2. The method according to claim 1, wherein the inflammatory mediator is formulated into nasal drops.

3. The method according to claim 2, wherein the inflammatory mediator is formulated in a concentration of about 0.1 mM to 10.0 mM.

4. The method according to claim 1, wherein the inflammatory mediator is formulated into a nasal ointment.

5. The method according to claim 4, wherein the inflammatory mediator is formulated in a concentration of 0.1 mM to 10.0 mM.

6. The method of claim 1 wherein the inflammatory response being reduced is at least one of the following:

oxygen radical production, hydrogen peroxide production, cytokine and protease production, prostaglandin production, erythema, histamine and interleukin production.

7. The method of claim 1 wherein the inflammatory mediator is at least one compound selected from the group consisting of:

a pyruvate precursor, pyruvate, and mixtures thereof.

8. The method of claim 7 wherein the inflammatory mediator is pyruvate.

9. The method of claim 7 wherein the pyruvate is selected from the group consisting of pyruvic acid, lithium pyruvate, sodium pyruvate, potassium pyruvate, magnesium pyruvate, calcium pyruvate, zinc pyruvate, manganese pyruvate, and mixtures thereof.

10. The method of claim 7 wherein the inflammatory mediator is a pyruvate precursor.

11. The method of claim 10 wherein the pyruvate precursor is selected from the group consisting of pyruvyl-glycene, pyruvyl-alanine, pyruvyl-leucine, pyruval cysteine, pyruvyl-valine, pyruvyl-isoleucine, pyruvyl-phenylalanine, pyruvamide, dihydroxyacetone, propylene glycol and salts of pyruvic acid.

12. The method of claim 1 wherein the disease state is selected from the group consisting of rhinitis, eosiophilia syndrome, and sinusitis.

13. The method of claim 1 further comprising contacting the mammalian nasal and sinus cells with a therapeutic agent.

14. The method of claim 13 wherein the therapeutic agent is administered prior to the inflammatory mediator.

15. The method of claim 13 wherein the therapeutic agent is administered concomitantly with administration of the inflammatory mediator.

16. The method of claim 13 wherein the therapeutic agent is administered after administration of the inflammatory mediator.

17. The method of claim 13 wherein the therapeutic agent is one or more agents selected from the group consisting of antibacterials, antivirals, antifungals, antihistamines, proteins, enzymes, hormones, nonsteroidal anti-inflammatories, cytokines, insulin, vitamins and steroids.

18. The method of claim 13 wherein the therapeutic agent is oxymetazoline.

26. The method of claim 13 wherein the therapeutic agent is oxymetazoline.

28. The method of claim 27, wherein the pyruvate is present in the solution at a concentration between from about 0.1 mM to about 10 mM.

29. The method of claim 27, wherein the buffer is selected from the group consisting of sodium bicarbonate, disodium phosphate/sodium phosphate, and monobasic potassium phosphate/sodium hydroxide.

30. The method of claim 27, wherein the pyruvate is present in the solution at a concentration of about 5 mM, the buffer is sodium bicarbonate, and the preservative is phenylcarbinol.

29-1. The method of claim 27, wherein the preservative is selected from the group consisting of phenylcarbinol, benzalkonium chloride, and thimerosal.