Ocular analyte sensor
First Claim
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1. An ophthalmic lens for detecting glucose in an ocular fluid, comprising:
- a receptor moiety layer, wherein receptor moieties in the receptor moiety layer comprises glucose oxidase molecules comprising glucose/competitor moiety binding sites;
a first and a second polyelectrolyte layer;
a competitor moiety layer, and detectable labels which are associated with the receptor moieties or the competitor moieties.
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Abstract
An ophthalmic lens comprising a receptor moiety can be used to determine the amount of an analyte in an ocular fluid. The receptor moiety can bind either a specific analyte or a detectably labeled competitor moiety. The amount of detectably labeled competitor moiety which is displaced from the receptor moiety by the analyte is measured and provides a means of determining analyte concentration in an ocular fluid, such as tears, aqueous humor, or interstitial fluid. The concentration of the analyte in the ocular fluid, in turn, indicates the concentration of the analyte in a fluid or tissue sample of the body, such as blood or intracellular fluid.
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Citations
28 Claims
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1. An ophthalmic lens for detecting glucose in an ocular fluid, comprising:
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a receptor moiety layer, wherein receptor moieties in the receptor moiety layer comprises glucose oxidase molecules comprising glucose/competitor moiety binding sites;
a first and a second polyelectrolyte layer;
a competitor moiety layer, and detectable labels which are associated with the receptor moieties or the competitor moieties. - View Dependent Claims (2, 3, 4, 5)
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6. A glucose sensor system, comprising:
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(a) an ophthalmic lens for detecting glucose in an ocular fluid, comprising;
(i) glucose oxidase molecules each of which comprises a glucose/competitor moiety binding site; and
(ii) a competitor moiety comprising a detectable label; and
(b) a detector configured to detect the detectable label. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method for measuring glucose concentration in an ocular fluid, comprising the steps of:
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(a) contacting the ocular fluid with an ophthalmic lens, wherein the ophthalmic lens comprises;
(i) glucose oxidase molecules each of which comprises a glucose/competitor moiety binding site; and
(ii) a competitor moiety which comprises a detectable label; and
(b) detecting the detectable label, wherein the amount of detectable label detected indicates the glucose concentration in the ocular fluid. - View Dependent Claims (17, 18, 19, 20)
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21. A method for varying glucose concentration in an ocular fluid, comprising the steps of:
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(a) contacting the ocular fluid with an ophthalmic lens, wherein the ophthalmic lens comprises;
(i) a competitor moiety which comprises a detectable label; and
(ii) glucose oxidase molecules each of which comprises a glucose/competitor moiety binding site;
(b) detecting the detectable label, wherein the amount of detectable label detected indicates the glucose concentration in a body tissue or fluid;
(c) transmitting a signal indicating the glucose concentration in the ocular fluid to a pump configured to vary the glucose concentration in the body tissue or fluid; and
(d) providing a regulator moiety via the pump to the body tissue or fluid, whereby the glucose concentration in the body tissue or fluid is varied. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
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Specification