High mass throughput particle generation using multiple nozzle spraying
First Claim
Patent Images
1. An electrospraying method, the method comprising:
- providing a plurality of nozzle structures, wherein each nozzle structure comprises at least one opening defined along a center axis of the nozzle structure and terminating at a dispensing end thereof from which a spray of particles having an electrical charge applied thereto is dispensed, wherein each nozzle structure is separated from adjacent nozzle structures by at least an internozzle distance (L) defined by the distance between center axes of the nozzle structures, wherein the ratio of the internozzle distance (L) to a diameter (D) of the opening at the dispensing end is equal to or greater than 2; and
dispensing the spray of particles from each nozzle structure by creating a nonuniform electrical field between the dispensing ends from which the sprays are established and an electrode electrically isolated from the dispensing ends.
2 Assignments
0 Petitions
Accused Products
Abstract
Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.
97 Citations
97 Claims
-
1. An electrospraying method, the method comprising:
-
providing a plurality of nozzle structures, wherein each nozzle structure comprises at least one opening defined along a center axis of the nozzle structure and terminating at a dispensing end thereof from which a spray of particles having an electrical charge applied thereto is dispensed, wherein each nozzle structure is separated from adjacent nozzle structures by at least an internozzle distance (L) defined by the distance between center axes of the nozzle structures, wherein the ratio of the internozzle distance (L) to a diameter (D) of the opening at the dispensing end is equal to or greater than 2; and
dispensing the spray of particles from each nozzle structure by creating a nonuniform electrical field between the dispensing ends from which the sprays are established and an electrode electrically isolated from the dispensing ends. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
-
-
22. An electrospraying method, the method comprising:
-
providing a circular configuration of nozzle structures comprising an outer ring of nozzle structures and one or more inner rings of nozzle structures, wherein each of the outer ring and the inner rings are concentric about a center nozzle structure, and further wherein the center nozzle structure and each of the nozzle structures of the one or more inner rings is at a substantially equal internozzle distance (L) from adjacent nozzle structures, and further wherein each of the nozzle structures comprises at least one opening defined along a center axis of the nozzle structure and terminating at a dispensing end thereof from which a spray of particles having an electrical charge applied thereto is dispensed; and
dispensing the spray of particles from each nozzle structure by creating a nonuniform electrical field between the dispensing ends from which the sprays are established and an electrode electrically isolated from the dispensing ends. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
-
-
37. An electrospraying method, the method comprising:
-
providing a plurality of nozzle structures, wherein each nozzle structure comprises at least one opening defined along a center axis of the nozzle structure at a dispensing end thereof from which a spray of particles having an electrical charge applied thereto is dispensed, wherein each nozzle structure is separated from adjacent nozzle structures by a distance;
structurally isolating the nozzle structures from one another such that a cone jet is allowed to form at the dispensing end of each nozzle structure; and
dispensing the spray of particles from each nozzle structure by creating a nonuniform electrical field between the dispensing ends from which the sprays are established and an electrode electrically isolated from the dispensing ends. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
-
-
51. An apparatus for electrospraying particles, the apparatus comprising:
-
a particle source; and
a dispensing device configured to receive source material from the particle source, wherein the dispensing device comprises a plurality of nozzle structures, wherein each nozzle structure comprises at least one opening defined along a center axis of the nozzle structure and terminating at a dispensing end thereof, wherein each nozzle structure is separated from adjacent nozzle structures by at least an internozzle distance (L) defined by the distance between center axes of nozzle structures, wherein the ratio of the internozzle distance (L) to a diameter (D) of the opening at the dispensing end is equal to or greater than 2; and
an electrode isolated from the dispensing end, wherein a nonuniform electrical field is created between the dispensing ends and the electrode such that a spray of particles having an electrical charge applied thereto is dispensed from the dispensing end of each nozzle structure. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70)
-
-
71. An apparatus for electrospraying particles, the apparatus comprising:
-
a particle source; and
a dispensing device configured to receive source material from the particle source, wherein the dispensing device comprises a circular configuration of nozzle structures comprising an outer ring of nozzle structures and one or more inner rings of nozzle structures, wherein each of the outer ring and the inner rings are concentric about a center nozzle structure, and further wherein the center nozzle structure and each of the nozzle structures of the inner rings are at a substantially equal internozzle distance (L) from adjacent nozzle structures, and further wherein each of the nozzles structures comprise an opening defined along a center axis of the nozzle structure and terminating at a dispensing end thereof from which a spray of particles having an electrical charge applied thereto is dispensed; and
an electrode isolated from the dispensing end, wherein a nonuniform electrical field is created between the dispensing ends and the electrode such that a spray of particles having an electrical charge applied thereto is dispensed from the dispensing end of each nozzle structure. - View Dependent Claims (72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
-
-
85. An apparatus for electrospraying particles, the apparatus comprising:
-
a particle source;
a dispensing device configured to receive source material from the particle source, wherein the dispensing device comprises a plurality of nozzle structures, wherein each nozzle structure comprises an opening defined along a center axis of the nozzle structure and terminating at a dispensing end thereof, and further wherein the dispensing device comprises one or more separation structures positioned between one or more of the nozzle structures and configured such that cone jets are allowed to form at the dispensing end of each nozzle structure; and
an electrode isolated from the dispensing end, wherein a nonuniform electrical field is created between the dispensing ends and the electrode such that a spray of particles having an electrical charge applied thereto is dispensed from the dispensing end of each nozzle structure. - View Dependent Claims (86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97)
-
Specification