Composition and method for treating inflammatory diseases
First Claim
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1. A method for treating a patient afflicted with an IL-1-mediated disease, comprising administering to a patient in need thereof a therapeutically effective amount of a fusion protein of IL-1ra with all or part of a constant domain of a heavy or light chain of human immunoglobulin at the amino-terminus, the carboxy-terminus or both.
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Abstract
A protein which exhibits a therapeutic effect on inflammation and is useful for treating IL-1-mediated inflammatory diseases, particularly diseases of the joint.
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20 Claims
- 1. A method for treating a patient afflicted with an IL-1-mediated disease, comprising administering to a patient in need thereof a therapeutically effective amount of a fusion protein of IL-1ra with all or part of a constant domain of a heavy or light chain of human immunoglobulin at the amino-terminus, the carboxy-terminus or both.
- 4. A pharmaceutical composition comprising an effective amount of a fusion protein of IL-1ra with all or part of a constant domain of a heavy or light chain of human immunoglobulin at the amino-terminus, the carboxy-terminus or both.
- 6. A method for treating a patient afflicted with an IL-1 mediated disease, comprising administering to a patient in need thereof a therapeutically effective amount of a composition comprising a controlled release polymer and a proteinaceous interleukin-1 inhibitor.
- 17. A pharmaceutical composition comprising an effective amount of a combination of a controlled release polymer and a proteinaceous interleukin-1 inhibitor.
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