ELECTRONICS METHODS FOR THE DETECTION OF ANALYTES
First Claim
Patent Images
1. A composition comprising an electrode comprising:
- a) a self-assembled monolayer; and
b) a metal ion ligand covalently attached to said electrode via a conductive oligomer.
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Abstract
The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
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Citations
19 Claims
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1. A composition comprising an electrode comprising:
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a) a self-assembled monolayer; and
b) a metal ion ligand covalently attached to said electrode via a conductive oligomer. - View Dependent Claims (2, 3, 4)
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5. A method of detecting a metal ion comprising:
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a) applying a first input signal to an assay complex comprising;
i) an electrode comprising;
1) a self-assembled monolayer;
2) a metal ion ligand covalently attached to said electrode via a conductive oligomer;
ii) a metal ion;
b) detecting a change in the faradaic impedance of the system as a result of the association of the metal ion with the metal ion ligand.
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6. A method of detecting a non-nucleic acid target analyte in a sample comprising:
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a) applying a first input signal to an assay complex comprising;
i) a redox active complex comprising;
1) a redox active molecule;
2) a binding ligand that will bind the target analyte; and
ii) a target analyte;
wherein at least one component of said assay complex is covalently attached to an electrode via conductive oligomer; and
b) detecting a change in the faradaic impedance of the system as a result of the association of the redox active molecule with the target analyte, if present. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. An apparatus for the detection of a non-nucleic acid target analyte in a test sample, comprising:
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a) a test chamber comprising at least a first and a second measuring electrode, wherein said first measuring electrode comprises;
i) a self-assembled monolayer;
ii) a binding ligand covalently attached to said electrode via conductive oligomer;
b) a voltage source electrically connected to said test chamber. - View Dependent Claims (19)
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Specification