Subthreshold stimulator for angiogenesis
First Claim
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1. A subthreshold pulse generator comprising:
- a.) a power supply; and
b.) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue.
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Abstract
The present invention provides a novel stimulatory device for the controlled production of angiogenic growth factors. More specifically, the present invention provides a subthreshold pulse generator for the local production of vascular endothelial growth factor.
104 Citations
68 Claims
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1. A subthreshold pulse generator comprising:
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a.) a power supply; and
b.) a control mechanism interconnected with the power supply to deliver a subthreshold pulse to a targeted cell or tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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- 34. A therapeutic delivery system comprising a subthreshold pulse generator operably linked with mammalian cells or tissue.
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50. A method of treating a patient comprising providing the patient with a subthreshold pulse generator operably linked with targeted mammalian cells or tissues.
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51. A method of treating a patient comprising providing the patient with a subthreshold pulse generator operably linked to the tissue for acute subthreshold stimulation therapy to improve angiogenesis.
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52. A method of treating a patient comprising delivering an electrical field over a predetermined period of time to a targeted cells or tissue to stimulate the production of VEGF expression.
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53. A method of increasing vascularization in a target tissue comprising providing subthreshold stimulatory pulses to the targeted muscle tissue.
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54. A method of increasing vascularization in a target tissue wherein the subthreshold stimulatory pulses are targeted to vascular muscle tissue.
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55. A method of increasing vascularization in a target tissue wherein the subthreshold stimulatory pulses are targeted to heart muscle tissue.
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56. A method of increasing vascularization in a target tissue wherein the subthreshold stimulatory pulses are targeted to skeletal muscle tissue.
- 57. A method of treating a patient comprising providing the patient with a subthreshold pulse generator operably linked to a muscle tissue for subthreshold stimulation therapy.
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66. A method of improving vascularization in a targeted tissue comprising the steps of:
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a. stimulating cultured cells with a subthreshold electrical field;
b. injecting the stimulated cells into the targeted body tissue. - View Dependent Claims (67)
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68. A method of improving vascularization in a targeted tissue comprising the steps of:
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a. injecting cells into a targeted body tissue; and
b. stimulating the injected cell area with subthreshold stimulation.
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Specification