Valdecoxib compositions
First Claim
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1. A pharmaceutical composition comprising particulate valdecoxib in an amount of about 1 mg to about 100 mg per dose and one or more pharmaceutically acceptable excipients, wherein a single dose, upon oral administration to a fasting subject, provides a time course of blood serum concentration of valdecoxib having at least one of (a) a time to reach a threshold concentration for therapeutic effect not greater than about 0.5 h after administration;
- (b) a time to reach maximum concentration (Tmax) not greater than about 5 h after administration; and
(c) a maximum concentration (Cmax) not less than about 100 ng/ml.
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Abstract
Pharmaceutical compositions are provided comprising particulate valdecoxib in an amount of about 1 mg to about 100 mg and one or more pharmaceutically acceptable excipients. The compositions are useful in treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders.
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Citations
18 Claims
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1. A pharmaceutical composition comprising particulate valdecoxib in an amount of about 1 mg to about 100 mg per dose and one or more pharmaceutically acceptable excipients, wherein a single dose, upon oral administration to a fasting subject, provides a time course of blood serum concentration of valdecoxib having at least one of
(a) a time to reach a threshold concentration for therapeutic effect not greater than about 0.5 h after administration; -
(b) a time to reach maximum concentration (Tmax) not greater than about 5 h after administration; and
(c) a maximum concentration (Cmax) not less than about 100 ng/ml. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification