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Method for enhancing outflow of aqueous humor in treatment of glaucoma

  • US 20020016346A1
  • Filed: 02/16/2001
  • Published: 02/07/2002
  • Est. Priority Date: 12/09/1994
  • Status: Active Grant
First Claim
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1. A method for screening compounds for utility in lowering intra-ocular pressure comprising:

  • (a) Determining the IC50 concentration of compounds in the cortical thick ascending limb of the loop of Henle;

    (b) Determining the inhibition of Na+

    K+

    2Cl

    cotransport in mammalian trabecular meshwork cells;

    (c) Selecting compounds with an IC50 at or below 0.30 μ

    M and an inhibition of Na+13 K+

    2Cl

    cotransport of at least 50%.

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