Optical imaging of subsurface anatomical structures and biomolecules
First Claim
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1. A method of optically imaging subsurface anatomic structures and biomolecules in an individual or animal with red light and infrared radiant energy, comprising the steps of:
- illuminating a region of interest with light from the red to radiant infrared portion of the light spectrum; and
, detecting red and infrared light from said region of interest with a red and infrared light sensitive image detector.
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Abstract
The present invention provides various methods/systems of optical imaging of subsurface anatomical structures and biomolecules utilizing red and infrared radiant energy. Also provided are various applications of such methods/systems in medical diagnosis and treatment.
590 Citations
31 Claims
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1. A method of optically imaging subsurface anatomic structures and biomolecules in an individual or animal with red light and infrared radiant energy, comprising the steps of:
illuminating a region of interest with light from the red to radiant infrared portion of the light spectrum; and
, detecting red and infrared light from said region of interest with a red and infrared light sensitive image detector.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of optically imaging subsurface anatomic structures and biomolecules by pulse oximetry, comprising the steps of:
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illuminating a region of interest with alternating wavelengths of light from the red to radiant infrared portion of the light spectrum; and
,detecting red infrared light from said region of interest with a pulse oximeter. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of obtaining depth specific information when optically imaging subsurface anatomic structures and biomolecules, comprising the steps of:
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illuminating a region of interest with narrow bands of light from the red to radiant infrared portion of the light spectrum; and
,detecting red and infrared light from said region of interest by confocal imaging. - View Dependent Claims (23, 24, 25, 27, 28, 30, 31)
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26. A method of optically imaging the location of a specific biomolecule in subsurface anatomic structures by Raman spectroscopy, comprising the steps of:
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illuminating a region of interest with a single wavelength of light from the red to radiant infrared portion of the light spectrum; and
,using Raman spectrosopy to detect frequencies and intensities of light emitted from said region of interest, wherein frequencies are specific to given biomolecules and intensities are indicative of the amount present;
analyzing said data as a function of location to construct a two or three dimensional image of the distribution of a detected biomolecule.
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29. A method of using laser speckle imaging to detect movement when optically imaging subsurface anatomic structures and biomolecules, comprising the steps of:
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illuminating a region of interest with coherent laser light in the red to radiant infrared portion of the light spectrum;
detecting a “
speckle”
pattern of light reflected from said region of interest with a sensitive detector; and
,monitoring movement said “
speckle”
pattern to detect movement.
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Specification