Method for diagnosis of and prognosis for damaged tissue
First Claim
1. A method for analyzing tissue based on quantized magnetic resonance data comprising the steps of a) selecting at least one magnetic resonance parameter to characterize a body part, organ or tissue, b) selecting a suitable pulse sequence to quantify that selected magnetic resonance parameter, c) using the selected pulse sequence to acquire multiple sets of magnetic resonance signals from the body part, organ or tissue at an unchanged position relative to the measurement acquisition system, d) quantifying the magnetic resonance imaging parameters on a pixel by pixel basis, e) determining biological properties of interest of a body part, organ or tissue structure by biological means including histological, biochemical, histochemical, and biomechanical, f) correlating quantitative ranges of the selected magnetic resonance parameters with selected biological properties of interest of a body party, organ or tissue.
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Abstract
Tissue is analyzed by acquiring multiple sets of magnetic resonance signals from a stationary body part, organ or tissue, quantizing the signals pixel by pixel within an area of interest, determining at least one magnetic resonance parameter in each pixel, and correlating the determined magnetic resonance parameter with predetermined magnetic resonance parameters that have been correlated with selected biological parameters of the body part, organ or tissue. The magnetic resonance parameter can be longitudinal relaxation time, transverse relaxation time, magnetization transfer, or magnetization ratio. The determined quantized magnetic parameter may be coded by color or otherwise with regard to the selected biological parameter and spatially displayed.
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Citations
15 Claims
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1. A method for analyzing tissue based on quantized magnetic resonance data comprising the steps of
a) selecting at least one magnetic resonance parameter to characterize a body part, organ or tissue, b) selecting a suitable pulse sequence to quantify that selected magnetic resonance parameter, c) using the selected pulse sequence to acquire multiple sets of magnetic resonance signals from the body part, organ or tissue at an unchanged position relative to the measurement acquisition system, d) quantifying the magnetic resonance imaging parameters on a pixel by pixel basis, e) determining biological properties of interest of a body part, organ or tissue structure by biological means including histological, biochemical, histochemical, and biomechanical, f) correlating quantitative ranges of the selected magnetic resonance parameters with selected biological properties of interest of a body party, organ or tissue.
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6. A method for analyzing tissue based on quantized magnetic resonance data comprising the steps of
a) acquiring magnetic resonance signals from the tissue, b) determining at least one magnetic resonance quality of tissue in each pixel, c) quantizing the magnetic resonance signals pixel by pixel within the tissue, and d) correlating the determined magnetic resonance quality with known magnetic resonance qualities of tissue.
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11. Magnetic resonance apparatus for use in analyzing a body comprising:
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a) means for establishing a magnetic field through the body, b) means for exciting nuclei spins in the body with an RF signal oriented at an angle with respect to said magnetic field, c) means for receiving magnetic resonance signals from the excited nuclei representative of said nuclei spins, d) repeating steps b) and c) to obtain a multiplicity of sets of magnetic resonance signals and determining a magnetic resonance quality from the body, and e) means for quantizing the magnetic resonance quality pixel by pixel within the body. - View Dependent Claims (12, 13, 14, 15)
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Specification