Poly(Propylene Fumarate) cross linked with Poly(Ethylene Glycol)

• US 20020022676A1
• Filed: 04/14/2000
• Published: 02/21/2002
• Est. Priority Date: 04/16/1999
• Status: Active Grant

• Current Assignee: Rice University
• Original Assignee: Rice University
• Inventors: He, Shulin, Yaszemski, Michael J., Mikos, Antonios G.
• Granted Patent: US 6,384,105 B1
• Time in Patent Office: Days
• US Class Current: 523/113
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08G 63/676 in which at least one of the two components contains aliphatic unsaturation
• CPC Class Codes: C08G 63/918 Polycarboxylic acids and polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
• CPC Class Codes: C08G 81/025 containing polyether sequences
• CPC Class Codes: C08L 67/00 Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain of polyester-amides C08L77/12; of polyester-imides C08L79/08; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 67/06 Unsaturated polyesters
• CPC Class Codes: C08L 67/07 having terminal carbon-to-carbon unsaturated bonds
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: Y10S 530/812 Peptides or proteins is immobilized on, or in, an organic carrier
• CPC Class Codes: Y10S 530/815 Carrier is a synthetic polymer

Abstract

New injectable, in situ crosslinkable biodegradable polymer composites comprise poly(propylene fumarate) (PPF), poly(ethylene glycol)-dimethacrylate (PEG-DMA), an, optionally, β-tricalcium phosphate (β-TCP). A method for controlling the crosslinking characteristics of the composites, including the maximum crosslinking temperature and the gel point, as well as the properties of the cross linked composites such as the compressive strength and modulus and the water holding capacity, is disclosed.

Claims

1. A polymer network comprising poly(propylene fumarate) and poly(ethylene glycol).

2. An injectable, in situ crosslinkable, biodegradable composite formulation comprising poly(propylene fumarate) and poly(ethylene glycol).

3. The composition according to claim 2, further including beta-tricalcium phosphate.

4. The composition according to claim 2 wherein the composition exhibits a temperature increase of less than 2°

C. during cross linking.

5. The composition according to claim 2 wherein the composition exhibits a gel point between 5-15 minutes.

7. The composition according to claim 4, further including beta-tricalcium phosphate.

8. The composition according to claim 2 wherein the composition exhibits a temperature increase of less than 2°

C. during cross linking.

9. The composition according to claim 2 wherein the composition exhibits a gel point between 5-15 minutes.

11. The composition according to claim 5, further including beta-tricalcium phosphate.

12. The composition according to claim 2 wherein the composition exhibits a temperature increase of less than 2°

C. during cross linking.

13. The composition according to claim 2 wherein the composition exhibits a gel point between 5-15 minutes.

6. An injectable, in situ crosslinkable, biodegradable carrier for cell transplantation, comprising poly(propylene fumarate) and poly(ethylene glycol).

10. An injectable, in situ crosslinkable, biodegradable carrier for bioactive drug delivery, comprising poly(propylene fumarate) and poly(ethylene glycol).