Method for the purification of aryl sulfonic acids and salts

• US 20020022743A1
• Filed: 01/05/2001
• Published: 02/21/2002
• Est. Priority Date: 01/10/2000
• Status: Abandoned Application

• Current Assignee: Renovis, Inc. (Evotec SE)
• Original Assignee: Renovis, Inc. (Evotec SE)
• Inventors: Jamieson, Gene, Kruk, Henry, Vajda, John, McGinley, John, Pouhov, Sergei
• Application Number:
  US09/755,619
• Publication Number:
  US 20020022743A1
• Time in Patent Office: Days
• US Class Current: 562/96
• CPC Class Codes: C07C 303/44 Separation; Purification
• CPC Class Codes: C07C 309/44 containing doubly-bound oxygen atoms bound to the carbon skeleton

Abstract

Solid aryl sulfonates are purified by preferentially dissolving impurities into an aqueous liquid phase.

Claims

1. A method for purifying an aryl sulfonate of formula I

2. The method according to claim 1 wherein the liquid phase comprises water in admixture with a carrier liquid.

3. The method according to claim 1 wherein the liquid phase consists essentially of water.

4. The method according to claim 2 where in the quantity of liquid phase is selected to dissolve not more than {fraction (1/2)} of the impure particulate solid.

5. The method according to claim 3 wherein the quantity of liquid phase is selected to dissolve not more than ½

of the impure particulate solid.

6. The method according to claim 1 wherein n is 1.

7. The method according to claim 1 wherein n is 2.

8. The method according to claim 1 wherein m is 1 and R is an aldehyde substituent.

9. The method according to claim 8 wherein the two Rs are both SO₃H.

10. The method according to claim 8 wherein the two Rs are both salts of SO₃H.

11. The method according to claim 8 wherein the aryl sulfonate of formula I is

12. The method according to claim 11 wherein X is Na.

13. The method according to claim 7 wherein m is 1 and R¹ is a nitrone substituent.

14. The method according to claim 13 wherein the two Rs are both SO₃H.

15. The method according to claim 13 wherein the two Rs are both salts of SO₃H.

16. The method according to claim 13 wherein the aryl sulfonate of formula I is

17. The method according to claim 16 wherein X is Na.

18. The method according to claim 1 wherein said recovering comprises drying.

20. A purified aryl sulfonate prepared by the method according to claim 1.

21. A purified aryl sulfonate prepared by the method according to claim 12.

22. A purified aryl sulfonate prepared by the method according to claim 17.

19. A method for purifying an aryl sulfonate of formula II

23. A purified aryl sulfonate prepared by the method according to claim 19.