Multichannel stimulator electronics and methods

• US 20020022866A1
• Filed: 04/19/2001
• Published: 02/21/2002
• Est. Priority Date: 08/17/2000
• Status: Active Grant

• Current Assignee: William N. Borkan
• Original Assignee: William N. Borkan
• Inventors: Borkan, William N.
• Granted Patent: US 6,662,053 B2
• Time in Patent Office: Days
• US Class Current: 607/59
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration

Abstract

A tissue stimulation system includes an electrode assembly having at least three electrodes spaced to be stimulated in a patient. A programmable stimulator is connected to and provides stimulation pulses to the electrode assembly. A programming data in the stimulator defines, for each of the at least three electrodes, individual stimulation pulses of varying polarity and at least one of amplitude, frequency, pulse width and pulse shape.

Claims

1. A tissue stimulation system comprising:

an electrode assembly having at least three electrodes to be stimulated in a patient;

a programmable stimulator connected to and providing stimulation pulses to the electrode assembly; and

programming data in the stimulator defining, for each of at least three electrodes, individual stimulation pulses of varying polarity and at least one of amplitude, frequency, pulse width and pulse shape.

2. A system according to claim 1, wherein the stimulator includes a pulse generator for each electrode.

3. A system according to claim 1, wherein the stimulator includes a common pulse generator and a separate variable impedance circuit for each electrode.

4. A system according to claim 3, wherein the variable impedance circuit includes a voltage divider for each electrode.

5. A system according to claim 3, wherein the variable impedance circuit includes an analog switch for each electrode.

6. A system according to claim 3, wherein the stimulator individually controls the amplitude and pulse width using the variable impedance circuit.

7. A system according to claim 1, wherein the stimulator measures the series impedance of each of the electrodes and modifies the stimulation pulse for each electrode defined by the programming data as a function of the measured impedance of that electrode.

8. A system according to claim 1, wherein the stimulator measures physical parameters and modifies the stimulation pulse for each electrode defined by the programming data as a function of the measured parameters.

9. A system according to claim 1, including an additional electrode spaced from the at least three electrodes and the additional electrode having a surface area greater than the surface area each of the at least three electrodes.

10. A system according to claim 9, wherein the additional electrode is at least twice the surface area of the surface area of each of the at least three electrodes.

11. A system according to claim 9, wherein the additional electrode is spaced from the at least three electrodes by at least ten millimeters.

12. A system according to claim 9, wherein the programming data defines simultaneously stimulation in a bipolar mode using at least two of the at least three electrodes and in a monopolar mode using the additional electrode as an anode electrode and at least one of the at least three electrodes as a cathode electrode.

13. A system according to claim 9, wherein the programming data defines stimulation in a bipolar mode.

14. A system according to claim 9, wherein the programming data defines stimulation in a monopolar mode using additional electrode as a common anode electrode with at least one of the at least three electrodes as a cathode electrode.

15. A system according to claim 1, including a measurement circuit to measure certain physiological parameters;

and wherein the stimulator modifies the stimulation pulses as a function of the measured parameters.

16. A system according to claim 15, wherein the measured parameters include one of the following:

EMG, EKG, or EEG measurements.

17. A system according to claim 15, wherein the measurement circuit include chemical or biochemical sensors.

18. A system according to claim 15, wherein the stimulator includes a signal input and modifies the stimulation pulses as a function of input signals on the signal input.

19. A system according to claim 18, wherein the input signals include processed audio or visual signals.

20. A system according to claim 15, wherein the stimulator determines the position of the electrode from the measured parameters and modifies the stimulation pulses as a function of the determined position.

21. A system according to claim 20, including a display for showing the determined position.

22. A method of tissue stimulation using an electrode assembly having at least three electrodes and having a programmable stimulator connected to the electrode assembly, the method comprising:

positioning the at least three electrodes to lie along a tissue to be stimulated in a patient; and

providing stimulation pulses, from the stimulator to at least three electrodes, with independently assigned polarities and at least one of amplitude, frequency, pulse width and pulse shape.

23. A method according to claim 22, including measuring the series impedance of each of the electrodes and modifying the stimulation pulse for each electrode defined as a function of the measured impedance of that electrode.

24. A method according to claim 22, including measuring physical parameters and modifying the stimulation pulse for each electrode defined as a function of the measured parameters.

25. A method according to claim 22, including simultaneously providing stimulation pulses to at least two of the at least three electrodes in a bipolar mode and to an additional electrode on the sheath as an anode and to at least one of the at least three electrodes as a cathode in a monopolar mode.

26. A method according to claim 22, including implanting the stimulator.

27. A method according to claim 22, including measuring certain physiological parameters;

and modifying the stimulation pulses as a function of the measured parameters.

28. A method according to claim 27, wherein the measured parameters include one of the following:

EMG, EKG, or EEG measurements.

29. A method according to claim 27, including obtaining information from at least one of pulmonary, cardiac or neuro monitors;

and modifying the stimulation pulses as a function of the information and measured parameters.

30. A method according to claim 22, including measuring physical parameters;

and determining the relative position of the electrodes to the desired tissue to be stimulated using the measured parameters.

31. A method according to claim 30, including displaying determined the electrode'"'"'s relative position.

32. A method according to claim 31, wherein the displaying overlays an image of the desired electrode position and/or movement on an x-ray or fluoroscopic image.

33. A method according to claim 30, wherein said system provides feedback to a physician as the electrode is moved in real time.

34. A method according to claim 30, including modifying the stimulation pulses as a function of the relative position.

35. A method according to claim 34, wherein measuring includes EMG measurements of specific muscles;

and modifying the stimulation pulses to determine the relative position of one or more of the individual electrodes.