Tissue engineering composite
First Claim
1. A composite for use in a living subject comprising a biocompatible three-dimensional porous support construct, and a carrier comprising a liquid or viscous fluid forming a gel matrix or viscous fluid when delivered into the body of a living subject.
2 Assignments
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Accused Products
Abstract
The invention provides a biocompatible composite for use in a living subject for purposes of repairing damaged tissues and reconstructing a new tissue. The composite includes a biodegradable or absorbable three-dimensional support construct, a liquid or viscous fluid forming a gel matrix or viscous fluid when delivered to an area of interest in a living subject. The biodegradable construct provides an ideal surface for cell or cell extract attachment, while the gel matrix or viscous fluid acts as both a carrier material and a separator for maintaining the space between the constructs as well as the structural integrity of the developing issue.
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Citations
80 Claims
- 1. A composite for use in a living subject comprising a biocompatible three-dimensional porous support construct, and a carrier comprising a liquid or viscous fluid forming a gel matrix or viscous fluid when delivered into the body of a living subject.
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13. A composite for use in a living subject comprising:
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a biocompatible porous three-dimensional construct comprising a material selected from the group consisting of alginate, collagen, polylactide, polyethylene glycol, polycaprolactone, polycolide, polydioxanone, and derivatives and copolymers thereof and having a size no greater than about 1.5 mm in diameter, and a carrier comprising a liquid or viscous fluid forming a gel matrix or a viscous fluid when injected into the body of a living subject said gel matrix or viscous fluid selected from the group consisting of biodegradable materials and non-biodegradable materials, each have a viscosity of from 10 to 1000 cps.
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14. A composite for use in a living subject comprising:
a biocompatible three-dimensional construct, a carrier comprising a liquid or viscous fluid forming a gel matrix or viscous fluid when injected into the body of a living subject, and cells disposed in said biocompatible three-dimensional support construct.
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29. A composite for use into a living subject comprising:
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a biocompatible porous three-dimensional construct comprising a material selected from the group consisting of alginate, collagen, polylactide, polyethylene glycol, polycaprolactone, polycolide, polydioxanone, and derivatives and copolymers thereof and having a size no greater than about 1.5 mm in diameter, a carrier comprising a liquid or viscous fluid capable of forming a carrier when injected into the body of a living subject said gel matrix selected form the group consisting of biodegradable materials and non-biodegradable materials, each having a viscosity of from 10 to 1000 cps; and
cells disposed in said biocompatible three-dimensional construct.
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33. A composite for use in a living subject comprising:
a biocompatible three-dimensional construct, a carrier comprising a liquid or viscous fluid forming a gel matrix or viscous fluid when injected into the body of a living subject, and cells disposed in said carrier. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 50, 51, 52)
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49. A composite for use in a living subject comprising:
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a biocompatible porous three-dimensional construct comprising a material selected from the group consisting of alginate, collagen, polylactide, polyethylene glycol, polycaprolactone, polycolide, polydioxanone, and derivatives and copolymers thereof and having a size no greater than about 1.5 mm in diameter, a carrier comprising a liquid or viscous fluid capable of forming a gel matrix or viscous fluid when injected into the body of a living subject said gel matrix selected form the group consisting of biodegradable materials and non-biodegradable materials, each having a viscosity of from 10 to 1000 cps; and
cells disposed in said biocompatible three-dimensional support construct and said carrier.
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53. A method of providing cells or tissue in a living subject comprising delivering into an area of interest in said living subject a composite comprising:
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(a) a biocompatible three-dimensional support construct having a porous structure which supports cell adhesion, growth and migration; and
(b) a carrier comprising a liquid or viscous fluid forming a gel matrix or viscous fluid when delivered into the body of a living subject. - View Dependent Claims (54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
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73. A method for repairing a defect in a breast of a female patient, comprising:
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providing an injectable composite comprising a biocompatible, biodegradable three-dimensional support construct made of collagen and containing cells obtained from said patient and selected from the group consisting of fibroblasts, smooth muscle cells, endothelial cells, mesenchymal cells, and a carrier comprising an alginate carrier, and injecting said composite into the area of the defect in the breast of the patient.
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74. A method for repairing a defect in a breast of a female patient, comprising:
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providing an injectable composite comprising a biocompatible, biodegradable three-dimensional support construct made of collagen and containing cells obtained from a cell bank and selected from the group consisting of fibroblasts, smooth muscle cells, endothelial cells, mesenchymal cells, and a carrier comprising an alginate carrier, and injecting said composite into the area of the defect in the breast of the patient.
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75. A method for repairing a defect in a breast of a female patient, comprising:
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providing an injectable composite comprising a biocompatible, biodegradable three-dimensional support construct made of polylactide based material and containing cells obtained from said patient and selected from the group consisting of fibroblasts, smooth muscle cells, endothelial cells, mesenchymal cells, and a carrier comprising an alginate carrier, and injecting said composite into the area of the defect in the breast of the patient.
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76. A method for repairing a facial defect in a patient, comprising:
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providing an injectable composite comprising a biocompatible, biodegradable three-dimensional support construct made of collagen and containing cells obtained from said patient and selected from the group consisting of fibroblasts, smooth muscle cells, endothelial cells, mesenchymal cells, and a carrier comprising an alginate carrier, and injecting said composite into the area of the defect in the breast of the patient.
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77. A method for repairing a facial defect in a patient, comprising:
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providing an injectable composite comprising a biocompatible, biodegradable porous three-dimensional support construct made from collagen and, a carrier comprising alginate; and
injecting said composite into the area of the defect in the face of the patient.
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78. A method for repairing a defect in a nipple of a female patient, comprising:
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providing an injectable composite comprising a biocompatible, biodegradable porous three-dimensional construct of collagen, and a carrier comprising alginate; and
injecting said composite into the area of the defect in the nipple of the patient.
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79. A method for repairing a spinal disc in a patient, comprising:
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providing an injectable composite comprising a biocompatible, biodegradable porous three-dimensional construct of collagen, said construct containing intervertebral disc cells obtained from said patient, and a carrier comprising alginate; and
injecting said composite into the spinal disc in the patient.
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80. A method for repairing a defect in a bone of a patient, comprising:
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providing an injectable composite comprising a biocompatible, biodegradable three-dimensional construct made from polylactide osteoblast cells obtained from said patient, and a carrier comprising alginate, and injecting said composite into the defective area of the bone in the patient.
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Specification