Method for blood infrared spectroscopy diagnosing of inner organs pathology

• US 20020027649A1
• Filed: 05/25/2001
• Published: 03/07/2002
• Est. Priority Date: 07/08/2000
• Status: Active Grant

• Current Assignee: Victor Chudner
• Original Assignee: Victor Chudner
• Inventors: Chudner, Victor
• Granted Patent: US 6,749,565 B2
• Time in Patent Office: Days
• US Class Current: 356/39
• CPC Class Codes: G01N 21/35 using infrared light G01N21/39 takes precedence

Abstract

A rapid diagnosis method for organ specific disease state is based on obtaining an infrared absorbance spectra of a patient'"'"'s blood at a frequency range from about 400 cm⁻¹ to about 2000 cm⁻¹ and further from about 3000 cm⁻¹ to about 3100 cm⁻¹. Comparing it with the predetermined normal infrared absorbance spectra of known healthy subjects for the presence or absence of predetermined features such as increase or decrease of infrared absorbance, peaks at particular frequencies allows for accurate diagnosis of a disease of an organ, including most major organs such as a heart, lungs, stomach, liver, kidneys, brain, etc.

Claims

1. A method for rapid diagnosis of an organ specific disease state of a subject, using an infrared spectroscopy of a blood sample of said subject, said method comprising the steps of:

irradiating said blood sample with an infrared light,

obtaining an infrared absorbance spectra of said blood sample in a frequency ranging from about 400 cm<sup>−

1</sup> to about 2000 cm<sup>−

1</sup> and further from about 3000 cm<sup>−

1</sup> to about 3100 cm<sup>−

1</sup>,

comparing said infrared absorbance spectra with a normal infrared absorbance spectra correspondingly obtained from blood of known healthy subjects,

identifying deviations of said infrared absorbance spectra from said normal infrared absorbance spectra in predetermined organ specific regions of said frequency range, and

providing a diagnosis for an organ specific disease state based on the presence of said deviations.

2. The method as in claim 1, wherein said subject being a human subject.

3. The method as in claim 1, further including a step of determining a degree of said organ specific disease state based on intensity of said deviations.

4. The method as in claim 2, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 600 cm⁻

1 to about 700 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a state of hypoxia.

5. The method as in claim 4, further including a step of examining said region of said infrared absorbance spectra for a presence of a peak at a frequency of about 620 cm⁻

1, whereby such presence indicating a state of asphyxia of neonates or forceful strangling in adults.

6. The method as in claim 4, further including a step of examining said region of said infrared absorbance spectra for a presence of a peak at a frequency of about 660 cm⁻

1, whereby such presence indicating a state of heart failure hypoxia.

7. The method as in claim 2, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 700 cm⁻

1 to about 800 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence including a state of liver failure.

8. The method as in claim 7, further including a step of examining said region of said infrared absorbance spectra for a presence of three peaks at the frequencies of about 720 cm⁻

1, 740 cm<sup>−

1</sup>, and 770 cm<sup>−

1</sup>, whereby such presence indicating a state of liver failure.

9. The method as in claim 2, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 800 cm⁻

1 to about 900 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a disease state of an organ selected from a group of organs consisting of a colon, kidneys, and endocrine glands.

10. The method as in claim 9, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 850 cm⁻

1 to about 860 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a disease state of kidneys.

11. The method as in claim 10, further including a step of examining said region of said infrared absorbance spectra for a presence of a peak at a frequency of about 850 cm⁻

1, whereby such presence indicating a state of acute nephritis or active form of chronic nephritis.

12. The method as in claim 10, further including a step of examining said region of said infrared absorbance spectra for a presence of a rounded negative peak at a frequency of about 850 cm⁻

1, said presence indicating a state of inactive form of chronic nephritis, correlated with nephrolithiasis and/or urinary sand.

13. The method as in claim 9, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 850 cm⁻

1 to about 900 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a disease state of a colon.

14. The method as in claim 13, further including a step of examining said region of said infrared absorbance spectra in a frequency range from about 850 cm⁻

1 to about 900 cm<sup>−

1</sup> for a presence of an increase in absorbance over said range of frequencies, said increase in comparison to said normal infrared absorbance spectra indicating a disease state of acute colitis.

15. The method as in claim 13, further including a step of examining a region of said infrared absorbance spectra in a frequency range from 850 cm⁻

1 to about 900 cm<sup>−

1</sup> for a presence of reduction in absorbance over said range of frequencies, said reduction in comparison to said normal infrared absorbance spectra indicating a disease state of chronic colitis.

16. The method as in claim 9, further including a step of examining a region of said infrared absorbance spectra for a presence of deviations from said normal infrared absorbance spectra in a frequency range from about 880 cm⁻

1 to about 900 cm<sup>−

1</sup>, said presence indicating a disease state of endocrine glands.

17. The method as in claim 16, further including a step of examining said region of said infrared absorbance spectra for a presence of an “

equilateral triangle”

-shaped sharp small peak at a frequency of about 880 cm<sup>−

1</sup>, said presence indicating a state of mild endocrine disorders correlated with a disease state of diencephalic syndrome and obesity.

18. The method as in claim 16, further including a step of examining said region of said infrared absorbance spectra for a presence of an elongated rounded peak at a frequency range from about 880 cm⁻

1 to about 890 cm<sup>−

1</sup> coupled with “

elliptical”

-like line at a frequency of about 865 cm<sup>−

1</sup>, whereby such presence indicating a state of severe endocrine disorder correlated with a disease state of pituitary dwarfism.

19. The method as in claim 16, further including a step of examining said region of said infrared absorbance spectra for a presence of a bulky “

trapezium”

-like peak with a flat top at a frequency range from about 880 cm<sup>−

1</sup> to about 890 cm<sup>−

1</sup> coupled with a “

V”

-shaped line at a frequency of about 870 cm<sup>−

1</sup>, said presence indicating a state of very severe endocrine disorder correlated with a disease state of congenital pigmented nevi.

20. The method as in claim 16, further including a step of examining said region of said infrared absorbance spectra for a presence of a slightly rounded negative peak at a frequency of about 890 cm⁻

1, whereby such presence indicating a state of thyroid gland disorders correlated with a disease state of hyperthyroidism.

21. The method as in claim 2, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 900 cm⁻

1 to about 1000 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a disease state of an organ selected from a group of organs consisting of a stomach, a pancreas, a duodenum, an jejunum, an ileum, an appendix, and also different tumors associated with immunodeficiency disorders.

22. The method as in claim 21, further including a step of examining said region of said infrared absorbance spectra in a frequency range from about 930 cm⁻

1 to about 950 cm<sup>−

1</sup> for a presence of deviations in absorbance (over said range of frequencies) from said normal infrared absorbance spectra, said presence indicating a state of stomach disease.

23. The method as in claim 22, further including a step of examining said region of said infrared absorbance spectra for a presence of a large rounded peak at a frequency from about 930 cm⁻

1 to about 950 cm<sup>−

1</sup>,which is much higher and wider than in normal condition, whereby such presence indicating a disease state of acute gastritis.

24. The method as in claim 22, further including a step of examining said region of said infrared absorbance spectra for a presence of a large “

trapezium”

-like peak at a frequency range from about 930 cm<sup>−

1</sup> to about 950 cm<sup>−

1</sup>, which is higher and wider than in normal condition, said presence indicating a disease state of chronic hypertrophic gastritis.

25. The method as in claim 22, further including a step of examining said region of said infrared absorbance spectra for a presence of a large “

trapezium”

-shaped peak with a “

terrace”

-like descent of both sides at a frequency range from about 930 cm<sup>−

1</sup> I to about 950 cm<sup>−

1</sup>, which is higher and wider than in normal condition, whereby such presence indicating a disease state of chronic atrophic gastritis.

26. The method as in claim 22, further including a step of examining said region of said infrared absorbance spectra for a presence of a reduced peak which transforms into a straight line at a frequency range from about 930 cm⁻

1 to about 950 cm<sup>−

1</sup>, said presence indicating a disease state of chronic hypoacidic gastritis.

27. The method as in claim 21, further including a step of examining said region of said infrared absorbance spectra for a presence of a sharp peak at a frequency of about 940 cm⁻

1 over the enlarged rounded peak at a frequency range from about 930 cm<sup>−

1</sup> to about 950 cm<sup>−

1</sup>, whereby such presence indicating a disease state of pancreatitis.

28. The method as in claim 21, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 950 cm⁻

1 to about 970 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a state of a duodenum disease.

29. The method as in claim 28, further including a step of examining said region of said infrared absorbance spectra for a presence of a small rounded peak at a frequency range from about 950 cm⁻

1 to about 970 cm<sup>−

1</sup>, said presence indicating a disease state of acute duodenitis.

30. The method as in claim 28, further including a step of examining said region of said infrared absorbance spectra for a presence of a straight line or a rounded (or sharp) negative peak at a frequency range from about 950 cm⁻

1 to about 970 cm<sup>−

1</sup>, whereby such presence indicating a disease state of chronic duodenitis.

31. The method as in claim 21, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 970 cm⁻

1 to about 1000 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a disease state of an jejunum and an ileum.

32. The method as in claim 31, further including a step of examining said region of said infrared absorbance spectra in a frequency range from about 970 cm⁻

1 to about 1000 cm<sup>−

1</sup> for a presence of a reduction in absorbance over said range of frequencies and flattening the absorbance band of the same height as the stomach portion of the chart, said reduction in comparison to said normal infrared absorbance spectra, indicating a disease state of enteritis with terminal ileitis.

33. The method as in claim 21, further including a step of examining said region of said infrared absorbance spectra for a presence of a “

V”

-shaped line at a frequency of about 960 cm<sup>−

1</sup> and a “

trapezium”

-like peak with a squint cut top at a frequency range from about 910 cm<sup>−

1</sup> to about 930 cm<sup>−

1</sup>, whereby such presence indicating a disease state of acute catarrhous appendicitis.

34. The method as in claim 21, further including a step of examining said region of said infrared absorbance spectra for a presence of an ascendent “

step”

-shaped line with a first step at a frequency range from about 935 cm<sup>−

1</sup> to about 970 cm<sup>−

1</sup> and a second step at a frequency range from about 970 cm<sup>−

1</sup> to about 1000 cm<sup>−

1</sup> 1 coupled with a little peak at a frequency of about 930 cm<sup>−

1</sup>, whereby such presence indicating a disease state of acute phlegmonous appendicitis.

35. The method as in claim 21, further including a step of examining a region of said infrared absorbance spectra at a frequency of about 908 cm⁻

1 for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a state of some tumor diseases associated with immunodeficiency disorders.

36. The method as in claim 35, further including a step of examining said region of said infrared absorbance spectra for a presence of a big peak at a frequency of about 908 cm⁻

1 with a wide base at a frequency range from about 880 cm<sup>−

1</sup> to about 930 cm<sup>−

1</sup> coupled with the lack of a peak at a frequency range from about 930 cm<sup>−

1</sup> to about 950 cm<sup>−

1</sup>, which is normally presented, whereby such presence indicating a state of a malignant tumor disease known as retroperitoneal lymphoma.

37. The method as in claim 35, further including a step of examining said region of said infrared absorbance spectra for a presence of a little peak at a frequency of about 908 cm⁻

1 coupled with a descendent “

step”

-like line with a first step at a frequency range from about 930 cm<sup>−

1</sup> to about 950 cm<sup>−

1</sup> and a second step at a frequency range from about 960 cm<sup>−

1</sup> to about 980 cm<sup>−

1</sup>, instead of a normally presented peak at a frequency range from about 930 cm<sup>−

1</sup> to about 950 cm<sup>−

1</sup>, said presence indicating a state of a benign tumor disease known as congenital pigmented nevi.

38. The method as in claims 13 and 31, further including a step of examining said region of said infrared absorbance spectra for a presence of a significant reduction in the infrared absorbance in the frequency range from about 850 cm⁻

1 to about 1000 cm<sup>−

1</sup> coupled with a large elliptical peak with a wide base at a frequency of about 930 cm<sup>−

1</sup>, occupying the range from about 900 cm<sup>−

1</sup> to about 950 cm<sup>−

1</sup>, whereby such presence indicating a disease state of insufficiency of ileocecal valve.

39. The method as in claims 13 and 31, further including a step of examining said region of said infrared absorbance spectra for a presence of a powerful decrease in the infrared absorbance in a frequency range of about 800 cm⁻

1 to about 1000 cm<sup>−

1</sup> coupled with a “

trough”

-shaped line with a wide hollow at a frequency range from about 860 cm<sup>−

1</sup> to about 950 cm<sup>−

1</sup>, said presence indicating a disease state of celiac sprue.

40. The method as in claims 13 and 31, further including a step of examining said region of said infrared absorbance spectra for a presence of a “

large broken wave”

-shaped line in the area ranging from about 850 cm<sup>−

1</sup> to about 1000 cm<sup>−

1</sup>, instead a normally presented absorbance band in this area, whereby such presence indicating a state of acute brucellosis with primarily gastrointestinal complications (acute colitis and acute enteritis).

41. The method as in claims 13 and 31, further including a step of examining said region of said infrared absorbance spectra for a presence of a peak at a frequency of about 980 cm⁻

1 of the same elevation as the stomach portion of the chart, coupled with a more sharp angle at a frequency of about 900 cm<sup>−

1</sup> (instead normally presented more rounded elliptic angle), said presence indicating a state of lambliasis.

42. The method as in claims 13 and 31, further including a step of examining said region of said infrared absorbance spectra for a presence of a sharp peak at a frequency of about 980 cm⁻

1, which is higher than the stomach portion of the chart, and simultaneous turn into the opposite side of the absorbance band in a frequency range from about 850 cm<sup>−

1</sup> to about 900 cm<sup>−

1</sup>, whereby such presence indicating a state of enterobiasis.

43. The method as in claim 13 and 31, further including a step of examining said region of said infrared absorbance spectra for a presence of a powerful increase in the infrared absorbance in a frequency range from about 720 cm⁻

1 to about 1000 cm<sup>−

1</sup> with a shift to the right and a turn into the opposite side, said presence indicating a state of dolichocolon (or extreme elongated colon).

44. The method as in claim 2, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 1000 cm⁻

1 to about 1130 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a disease state of an organ selected from a group of organs, consisting of a liver and immune system.

45. The method as in claim 44, further including a step of examining said region of said infrared absorbance spectra for a presence of two sharp elongated peaks at the frequencies of about 1030 cm⁻

1 and 1060 cm<sup>−

1</sup>, having a “

M”

-shaped line, whereby such presence indicating a state of very severe immunodeficiency, correlated with malignant tumor, such as retroperitoneal lymphoma.

46. The method as in claim 44, further including a step of examining said region of said infrared absorbance spectra for a presence of two pronounced wide peaks at the frequencies of about 1050 cm⁻

1 and 1080 cm<sup>−

1</sup>, having a “

M”

-shaped bending line, said presence indicating a state of severe immunodeficiency, correlated with benign tumor, such as congenital pigmented nevi.

47. The method as in claim 44, further including a step of examining said region of said infrared absorbance spectra for a presence of a small peak at a frequency of about 1050 cm⁻

1 and a large rounded peak with a wide base at a frequency of about 1090 cm<sup>−

1</sup>, whereby such presence indicating a state of moderate immunodeficiency and allergy, correlated with Wiskott-Aldrich syndrome.

48. The method as in claim 44, further including a step of examining said region of said infrared absorbance spectra for a presence of a big large rounded peak at a frequency range from about 1080 cm⁻

1 to about 1100 cm<sup>−

1</sup>, said presence indicating a state of allergy, correlated with bronchial asthma.

49. The method as in claim 44, further including a step of examining said region of said infrared absorbance spectra for a presence of a sharp peak at a frequency of about 1100 cm⁻

1, whereby such presence indicating a state of acute cholecystitis.

50. The method as in claim 44, further including a step of examining said region of said infrared absorbance spectra for a presence of a peak with a “

long broken and almost horizontal line”

-shaped top at a frequency range from about 1030 cm<sup>−

1</sup> to about 1110 cm<sup>−

1</sup>, said presence indicating a state of acute viral hepatitis.

51. The method as in claim 2, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 1100 cm⁻

1 to about 1200 cm<sup>−

1</sup>, especially the peaks at the frequencies of about 1130 cm<sup>−

1</sup> and 1160 cm<sup>−

1</sup>, for a presence of simultaneous deviations from said normal infrared absorbance spectra, said presence indicating a disease state of upper respiratory tract and lungs.

52. The method as in claim 51, further including a step of examining a region of said infrared absorbance spectra for a presence of a sharp simultaneous increase in the infrared absorbance in a frequency range from about 1100 cm⁻

1 to about 1200 cm<sup>−

1</sup>, especially a peak at a frequency of about 1130 cm<sup>−

1</sup> and a peak at a frequency of about 1160 cm<sup>−

1</sup> (which can occasionally merging into a single large peak), whereby such presence indicating a state of acute pneumonia, if the ratio of the peaks at about 1130 cm<sup>−

1</sup>-1160 cm<sup>−

1</sup> to the peak at about 1250 cm<sup>−

1</sup> is about 2.6 or more, or acute viral respiratory infection, if the above peak ratio ranging from about 1.8 to about 2.2. (in norm-0.8).

53. The method as in claim 51, further including a step of examining said region of said infrared absorbance spectra for a presence of a sharp simultaneous reduction in the infrared absorbance in a frequency range from about 1100 cm⁻

1 to about 1200 cm<sup>−

1</sup>, especially the peaks at the frequencies of about 1130 cm<sup>−

1</sup> and 1160 cm<sup>−

1</sup>, said reduction in comparison to said normal infrared absorbance spectra indicating a state of resolving neonatal pneumonia, if the ratio of the peaks at a frequency of about 1130 cm<sup>−

1</sup>-1160 cm<sup>−

1</sup> and at a frequency of about 1250 cm<sup>−

1</sup> is about 0.7 or less. (in norm-0.8).

54. The method as in claim 2, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 1160 cm⁻

1 to about 1350 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a disease state of a heart.

55. The method as in claim 54, further including a step of examining a region of said infrared absorbance spectra in the area of a peak at a frequency of about 1160 cm⁻

1 for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a disease state of a myocardium.

56. The method as in claim 55, further including a step of examining said region of said infrared absorbance spectra for a presence of a pronounced elongated “

trapezium”

-like peak with a cut top at a frequency of about 1160 cm<sup>−

1</sup>, which is higher and narrower than in normal condition, whereby such presence indicating a state of acute myocarditis.

57. The method as in claim 55, further including a step of examining said region of said infrared absorbance spectra for a presence of a widened flattened peak at a frequency range from about 1140 cm⁻

1 to about 1160 cm<sup>−

1</sup>, with a split widened top at a frequency of about 1150 cm<sup>−

1</sup>, which is wider and flatter than in normal condition, whereby such presence indicating a state of cardiomyopathy.

58. The method as in claim 55, further including a step of examining said region of said infrared absorbance spectra for a presence of a peak at a frequency of about 1160 cm⁻

1, the lack of said presence indicating a state of myocardial infarction.

59. The method as in claim 54, further including a step of examining a region of said infrared absorbance spectra for a presence of an increase in the infrared absorbance in a frequency range from about 1180 cm⁻

1 to about 1200 cm<sup>−

1</sup>, said increase in comparison to said normal infrared absorbance spectra indicating a state of heart insufficiency or heart failure.

60. The method as in claim 59, further including a step of examining said region of said infrared absorbance spectra for a presence of a “

semi-moon”

clipping in a frequency range from about 1180 cm<sup>−

1</sup> to about 1200 cm<sup>−

1</sup>, whereby such presence indicating a state of functional murmur.

61. The method as in claim 59, further including a step of examining said region of said infrared absorbance spectra for a presence of a “

broken curve”

line in a frequency range from about 1180 cm<sup>−

1</sup> to about 1200 cm<sup>−

1</sup>, said presence indicating a state of mitral valve prolapse.

62. The method as in claim 59, further including a step of examining said region of said infrared absorbance spectra for a presence of an ascendent “

step”

-like line with a first step at a frequency range from about 1180 cm<sup>−

1</sup> to about 1189 cm<sup>−

1</sup> and a second high, slanting step at a frequency range from about 1190 cm<sup>−

1</sup> to about 1200 cm<sup>−

1</sup>, whereby such presence indicating a state of congenital atrial and ventricular septal defect.

63. The method as in claims 55 and 59, further including a step of examining said region of said infrared absorbance spectra for a presence of a “

crown (mitra)”

-shaped peak at a frequency of about 1192 cm<sup>−

1</sup> with a wide curve base ranging from about 1180 cm<sup>−

1</sup> to about 1200 cm<sup>−

1</sup> coupled with an elliptical rounded peak at a frequency of about 1150 cm<sup>−

1</sup>-1170 cm<sup>−

1</sup>, which is smaller than in normal condition, said presence indicating a state of rheumatic mitral regurgitation.

64. The method as in claims 55 and 59, further including a step of examining said region of said infrared absorbance spectra for a presence of a “

turned-over equilateral triangle”

-like peak at a frequency range from about 1180 cm<sup>−

1</sup> to about 1200 cm<sup>−

1</sup> coupled with a “

femur head”

-shaped elongated peak at a frequency of about 1150 cm<sup>−

1</sup> -1170 cm<sup>−

1</sup>, which is longer than in normal condition, whereby such presence indicating a state of aortal stenosis.

65. The method as in claims 55 and 59, further including a step of examining said region of said infrared absorbance spectra for a presence of a “

high step”

-shaped peak at a frequency range from about 1190 cm<sup>−

1</sup> to about 1200 cm<sup>−

1</sup> coupled with a wide “

trapezium”

-like peak at a frequency range from about 1160 cm<sup>−

1</sup> to about 1180 cm<sup>−

1</sup>, which is smaller than in normal condition, said presence indicating a state of myocardial ischemia.

66. The method as in claim 54, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 1200 cm⁻

1 to about 1350 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a disease state of a heart conductive system.

67. The method as in claim 66, further including a step of examining said region of said infrared absorbance spectra for a presence of a peak at a frequency of about 1230 cm⁻

1, which is smaller than in normal condition, coupled with three small peaks at the frequencies of about 1270 cm<sup>−

1</sup>, 1300 cm<sup>−

1</sup> and 1330 cm<sup>−

1</sup>, whereby such presence indicating a state of severe cardiac arrhythmia.

68. The method as in claim 2, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 1400 cm⁻

1 to about 1700 cm<sup>−

1</sup> for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a disease state of brain and central nervous system.

69. The method as in claim 68, further including a step of examining a region of said infrared absorbance spectra for a presence of deviations in a frequency range from about 1400 cm⁻

1 to about 1500 cm<sup>−

1</sup>, including peaks at the frequencies of about 1410 cm<sup>−

1</sup> and 1460 cm<sup>−

1</sup>, said presence indicating a state of less severe functional damages of brain and central nervous system, such as neurosis, minor degree of intracranial hypertension, early stage of convulsion disorders, etc.

70. The method as in claim 68, further including a step of examining a region of said infrared absorbance spectra for a presence of deviations in a frequency range from about 1500 cm⁻

1 to about 1700 cm<sup>−

1</sup>, including peaks at the frequencies of about 1550 cm<sup>−

1</sup> and 1650 cm<sup>−

1</sup>, said presence indicating a state of more severe (organic, anatomic or inflammatory) damages of brain and central nervous system, like head trauma, severe hypoxic ischemic perinatal encephalopathy with intracranial intraventricular hemorrhage, meningitis, cerebrosclerosis, etc.

71. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for a sharp increase in the infrared absorbance at a frequency of about 1460 cm⁻

1 in such a way that the ratio of the peak at about 1410 cm<sup>−

1</sup> to the peak at about 1460 cm<sup>−

1</sup> becomes less than 1.0 (in norm-1.0) or a presence of an almost horizontal line in a frequency range from about 1450 cm<sup>−

1</sup> to about 1500 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1460 cm<sup>−

1</sup>), whereby such presence indicating a state of neurosis.

72. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for a sharp decrease in the infrared absorbance at a frequency of about 1460 cm⁻

1, whereby such presence indicating a state of epilepsy, if the ratio of the peak at about 1410 cm<sup>−

1</sup> to the peak at about 1460 cm<sup>−

1</sup> is equal 2.0 and more or a state of convulsion disorders, if the above peak ratio is in the range from about 1.7 to about 2.0 (in norm-1.0).

73. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for a presence of a large elongated “

trapezium”

-like peak with a cut top at a frequency of about 1395 cm<sup>−

1</sup> (which is normally smaller and located at a frequency of about 1410 cm<sup>−

1</sup>) coupled with an enlarged and widened peak at a frequency of about 1450 cm<sup>−

1</sup> which splits at the right lower side with an appearance of a new little peak at a frequency of about 1470 cm<sup>−

1</sup> (normally there is only one peak at a frequency of about 1460 cm<sup>−

1</sup>), whereby such presence indicating a state of severe intracranial hypertension.

74. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for only one change, namely a little widening of the right lower side of a peak at a frequency of about 1460 cm⁻

1, whereby such presence indicating a state of minor degree of intracranial hypertension in otherwise healthy men.

75. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:

three large peaks at the frequencies of about 1590 cm<sup>−

1</sup>-1610 cm<sup>−

1</sup>, 1640 cm<sup>−

1</sup>-1650 cm<sup>−

1</sup> and 1660 cm<sup>−

1</sup> -1680 cm<sup>−

1</sup> on the top of a big peak at a frequency of about 1650 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1650 cm<sup>−

1</sup>),

total lack of a peak at a frequency of about 1550 cm<sup>−

1</sup> l(instead a normally presented peak at a frequency of about 1550 cm<sup>−

1</sup>),

the lack of peaks at the frequencies of about 1460 cm<sup>−

1</sup> and 1410 cm<sup>−

1</sup> with transformation into a “

saw”

-shaped line with a multitude of smaller peaks in a frequency range from about 1380 cm<sup>−

1</sup> to about 1460 cm<sup>−

1</sup> (instead the normally presented peaks at the frequencies of about 1460 cm<sup>−

1</sup> and 1410 cm⁻

), whereby such presence indicating a state of severe hypoxic ischemic perinatal enceplopathy with intracranial intraventricular hemorrhage.

76. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:

two small peaks of the same elevation at the frequencies of about 1630 cm<sup>−

1</sup> and 1665 cm<sup>−

1</sup> on the top of a big peak at a frequency of about 1650 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1650 cm<sup>−

1</sup>),

a “

terrace”

-like descendent line in a frequency range from about 1500 cm<sup>−

1</sup> to about 1600 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1550 cm<sup>−

1</sup>),

a short and wide “

trapezium”

-like peak with a cut top at a frequency range from about 1450 cm<sup>−

1</sup> to about 1480 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1460 cm<sup>−

1</sup>),

a short and wide “

trapezium”

-shaped peak with a cut top at a frequency range from about 1390 cm<sup>−

1</sup> to about 1410 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1410 cm<sup>−

1</sup>),

whereby such presence indicating a state of hypoxic ischemic perinatal encephalopathy of a moderate degree.

77. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:

two small peaks with different elevation;

a higher peak at a frequency of about 1670 cm<sup>−

1</sup> and a lower peak at a frequency of about 1645 cm<sup>−

1</sup> on the top of a big peak at a frequency of about 1650 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1650 cm<sup>−

1</sup>),

a “

saw”

-like horizontal line with a multitude of smaller peaks in a frequency range from about 1540 cm<sup>−

1</sup> to about 1610 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1550 cm<sup>−

1</sup>),

a widened and flattened peak at a frequency of about 1460 cm<sup>−

1</sup>, which is normally higher and narrower,

a slightly widened and flattened peak at a frequency of about 1400 cm<sup>−

1</sup>, whereby such presence indicating a state of hypoxic ischemic perinatal encephalopathy of a mild degree.

78. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:

a small elongated “

rectangular”

-shaped peak at a frequency range from about 1660 cm<sup>−

1</sup> to about 1670 cm<sup>−

1</sup> and a small flat “

tent”

-like peak at a frequency of about 1650 cm<sup>−

1</sup> on the top of a big peak at a frequency of about 1650 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1650 cm<sup>−

1</sup>),

three small peaks at the same elevation at the frequencies of about 1510 cm<sup>−

1</sup>, 1530 cm<sup>−

1</sup> and 1550 cm<sup>−

1</sup> on the top of a big peak at a frequency of about 1550 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1650 cm<sup>−

1</sup>),

an elongated peak at a frequency of about 1450 cm<sup>−

1</sup> which splits on the top into two smaller peaks at frequencies of about 1440 cm<sup>−

1</sup> and 1455 cm<sup>−

1</sup>,

an elongated peak at a frequency range from about 1390 cm<sup>−

1</sup> to about 1410 cm<sup>−

1</sup> with a little sharp peak on the top at a frequency of about 1390 cm<sup>−

1</sup>,

whereby such presence indicating a state of brain injury of a minor degree.

79. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:

two large widened and flattened peaks at the frequencies of about 1620 cm<sup>−

1</sup> and 1640 cm<sup>−

1</sup> on the top of a big peak at a frequency of about 1650 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1650 cm<sup>−

1</sup>),

a “

wave”

-like horizontal line in a frequency range from about 1510 cm<sup>−

1</sup> to about 1600 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1550 cm<sup>−

1</sup>),

a peak at a frequency of about 1430 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1460 cm<sup>−

1</sup>),

a flattened rounded peak at a frequency of about 1390 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1410 cm<sup>−

1</sup>),

reduction of the ratio of the peak at about 1390 cm<sup>−

1</sup> to the peak at about 1430 cm<sup>−

1</sup> to about 0.4 (in norm-1.0),

whereby such presence indicating a state of postnatal head injury of a moderate degree.

80. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:

two bulky peaks (on the top of a big peak at a frequency of about 1650 cm<sup>−

1</sup>) at the frequencies of about 1640 cm<sup>−

1</sup> and 1660 cm<sup>−

1</sup>-1680 cm<sup>−

1</sup>,

three pronounced peaks of the different elevation (on the top of a big peak at a frequency of about 1550 cm<sup>−

1</sup>) at the frequencies of about 1510 cm<sup>−

1</sup>, 1530 cm<sup>−

1</sup>-1540 cm<sup>−

1</sup> and 1560 cm<sup>−

1</sup>,

two peaks at the frequencies of about 1450 cm<sup>−

1</sup> and 1470 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1460 cm<sup>−

1</sup>),

a dramatically enlarged peak at a frequency of about 1390 cm<sup>−

1</sup> (instead a normally presented a peak at a frequency of about 1410 cm<sup>−

1</sup>),

whereby such presence indicating a state of severe acute bacterial meningitis.

81. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:

a dramatically enlarged and much sharper than the more rounded in norm peaks at the frequencies of about 1650 cm<sup>−

1</sup>, 1550 cm<sup>−

1</sup>, 1450 cm<sup>−

1</sup> and 1390 cm<sup>−

1</sup>,

increase of the ratio of the peak at about 1390 cm<sup>−

1</sup> to the peak at about 1450 cm<sup>−

1</sup> up to about 1.2-1.3 (in norm-1.0),

whereby such presence indicating a state of cerebrosclerosis.

82. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:

a split without divergence on the top of a peak at a frequency of about 1650 cm<sup>−

1</sup> with a transformation into two elongated peaks at frequencies of about 1640 cm<sup>−

1</sup> and 1660 cm<sup>−

1</sup>,

a similar split without divergence on the top of a peak at a frequency of about 1550 cm<sup>−

1</sup> with a transformation into two elongated peaks at frequencies of about 1540 cm<sup>−

1</sup> and 1560 cm<sup>−

1</sup>,

a new peak at a frequency of about 1580 cm<sup>−

1</sup>, which is absent in norm,

a dramatically enlarged peak at a frequency of about 1450 cm<sup>−

1</sup> with a vertical line on the top (instead a normally presented peak at a frequency of about 1460 cm<sup>−

1</sup>),

a sharp absorbance drop at a frequency of about 1480 cm<sup>−

1</sup>,

a dramatically elongated peak at a frequency of about 1390 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1410 cm<sup>−

1</sup>),

whereby such presence indicating a state of rheumatic chorea.

83. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:

a very elongated “

trapezium”

-like peak with a hollow cut top at a frequency range from about 1670 cm<sup>−

1</sup> to about 1690 cm<sup>−

1</sup> with a widened base, occupying the range from about 1600 cm<sup>−

1</sup> to about 1740 cm<sup>−

1</sup>,

a wide “

rectangular-trapezium”

-like peak with a “

wave”

-shaped top at a frequency range from about 1500 cm<sup>−

1</sup> to about 1570 cm<sup>−

1</sup> with a small peak on the top at a frequency of about 1545 cm<sup>−

1</sup> and a wide base, occupying the range from about 1480 cm<sup>−

1</sup> to about 1580 cm<sup>−

1</sup>,

a small peak at a frequency of about 1450 cm<sup>−

1</sup> and a little peak at a frequency of about 1470 cm<sup>−

1</sup> (instead a normally presented peak at a frequency of about 1460 cm<sup>−

1</sup>),

a flattened and widened peak at a frequency of about 1390 cm<sup>−

1</sup> with a wide base, occupying the range from about 1390 cm<sup>−

1</sup> to about 1400 cm<sup>−

1</sup>,

a reduction of the ratio of the peak at about 1390 cm<sup>−

1</sup> to the peak at about 1460 cm<sup>−

1</sup> to about 0.4 (in norm-1.0),

whereby such presence indicating a state of severe brain damage in a developmentally disabled blind infant with physical and mental retardation in one year after a postnatal head injury.

84. The method as in claim 2, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 3000 cm⁻

1 to about 3100 cm<sup>−

1</sup>, especially of a peak at a frequency of about 3060 cm<sup>−

1</sup>, for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a state of chronic infection.

85. The method as in claim 84, further including a step of examining said region of said infrared absorbance spectra for a presence of reduction in the infrared absorbance in the range from about 3000 cm⁻

1 to about 3100 cm<sup>−

1</sup>, especially of a peak at a frequency of about 3060 cm<sup>−

1</sup>, in such a way that the ratio of the height for the rising line to that of a subsequently declining line drops to about 2 (in norm-5;

for other chronic infections 2.5-4.5), whereby such reduction indicating a state of pulmonary tuberculosis.