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Oligosaccharide aldonic acids and their topical use

  • US 20020028227A1
  • Filed: 11/13/2001
  • Published: 03/07/2002
  • Est. Priority Date: 06/30/1999
  • Status: Active Grant
First Claim
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1. A composition comprising (A) an acceptable vehicle or base and (B) at least one compound selected from the group consisting of oligosaccharaide aldonic acids and related compounds, and isomeric or nonisomeric, free acid, ester, salt, partial salt, lactone, saturated or unsaturated, and straight or branched chain, or cyclic forms thereof, wherein said oligosaccharide aldonic acid has the formula:

  • R1(CHOR2)m(CH2)n COOR3 wherein, R1 and R3 are independently H or an alky, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having from 1 to 25 carbon atoms;

    mis 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11;

    n is 0, 1, 2, 3, 4, 5, 6, 7, 8, or 9;

    R2 is independently selected from the group consisting of H and any carbohydrate having 1 to 9 monomers, wherein at least one R2 is a carbohydrate;

    H attached to carbon atom is optionally substituted by I, F, Cl, Br, NH2, NHCOCH3, SH, or an alkyl, alkoxyl, aralkyl or aryl group of saturated or unsaturated, straight or branched chain or cyclic form, having 1 to 9 carbon atoms;

    R1, R2, OR2 or H optionally carry or are optionally substituted with CHO, COOH, sulfate, phosphate, nitrate, or a lower alkoxyl having 1 to 5 carbon atoms; and

    H of the OH group is optionally substituted by an acyl group having from 2 to 25 carbon atoms, and wherein said oligosaccharide aldonic acid is not lactobionic acid.

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