Process, device and reagent for cell separation
First Claim
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1. A cell separation process for the isolation of pathogenic cells in a small concentration in a biological fluid specimen, comprising:
- treating the biological specimen to modify in a differential manner selected rare cells and other cells; and
causing differential migration of cells that reacted during treatment versus cells that did not react during treatment.
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Abstract
A cell separation process for the isolation of pathogenic cells in a small concentration in a biological fluid specimen, including treating the biological specimen to modify in a differential manner selected rare cells and other cells and causing differential migration of cells that reacted during treatment versus cells that did not react during treatment.
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Citations
20 Claims
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1. A cell separation process for the isolation of pathogenic cells in a small concentration in a biological fluid specimen, comprising:
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treating the biological specimen to modify in a differential manner selected rare cells and other cells; and
causing differential migration of cells that reacted during treatment versus cells that did not react during treatment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20)
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8. A process for the detection of cells capable of being present in a very low concentration in a biological fluid specimen comprising:
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reacting a reagent specific to particles to be detected in the specimen or, specific to particles normally present in the biological specimen and capable of masking the presence of targeted cells to modify physical properties of the cells that reacted;
performing an enrichment of a part of the specimen by a physical selection process ensuring differential migration of the particles that reacted with the reagent versus the particles that did not react;
performing a visualization of the possible presence of the targeted particles in the part of the specimen enriched in targeted particles. - View Dependent Claims (9)
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13. A device for the separation of pathogenic cells in a blood specimen, comprising a filtration membrane with a pore size between 5 and 10 μ
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Specification