Antimicrobial compositions

• US 20020028754A1
• Filed: 07/05/2001
• Published: 03/07/2002
• Est. Priority Date: 07/21/2000
• Status: Abandoned Application

• Current Assignee: Novozymes A/S (Novozymes)
• Original Assignee: Novozymes A/S (Novozymes)
• Inventors: Aaslyng, Dorrit, Johansen, Charlotte
• Application Number:
  US09/899,689
• Publication Number:
  US 20020028754A1
• Time in Patent Office: Days
• US Class Current: 510/302
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 37/40 having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
• CPC Class Codes: A01N 37/46 N-acyl derivatives
• CPC Class Codes: A01N 43/80 five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A01N 61/00 Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
• CPC Class Codes: A01N 63/50 Isolated enzymes; Isolated proteins peptides A01N37/46
• CPC Class Codes: A61K 2800/524 Preservatives
• CPC Class Codes: A61K 8/49 containing heterocyclic compounds
• CPC Class Codes: A61K 8/66 Enzymes
• CPC Class Codes: A61L 2/0082 using chemical substances
• CPC Class Codes: A61L 2/16 using chemical substances
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: C02F 1/50 by addition or application of a germicide or by oligodynamic treatment C02F1/4606, C02F1/467, C02F1/76 take precedence
• CPC Class Codes: C11D 11/0017 "Soft" surfaces, e.g. textiles
• CPC Class Codes: C11D 11/0023 "Hard" surfaces
• CPC Class Codes: C11D 11/0041 Industrial or commercial equipment, e.g. reactors, tubes or engines C11D11/0047 takes precedence
• CPC Class Codes: C11D 2111/12 Soft surfaces, e.g. textile
• CPC Class Codes: C11D 2111/14 Hard surfaces
• CPC Class Codes: C11D 2111/20 : Industrial or commercial equipment, e.g. reactors, tubes or engines
• CPC Class Codes: C11D 3/38636 : containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
• CPC Class Codes: C11D 3/38654 : containing oxidase or reductase
• CPC Class Codes: C11D 3/48 : Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

The invention provides an antimicrobial composition comprising an enzymatic component and one or more non-enzymatic biocides; a method for killing or inhibiting microbial cells comprising a treatment with the antimicrobial composition; and a detergent composition comprising the antimicrobial composition. The invention provides an improved antimicrobial effect.

Claims

1. An antimicrobial composition comprising an enzymatic component and one or more non-enzymatic biocides.

2. The composition of claim 1, wherein the enzymatic component comprises an oxidoreductase and a suitable oxidizing agent.

3. The composition of claim 2, wherein the enzymatic component comprises a peroxidase and a source of hydrogen peroxide.

4. The composition of claim 2, wherein the enzymatic component comprises a haloperoxidase, a source of hydrogen peroxide and a source of halide.

5. The composition of claim 2, wherein the enzymatic component comprises a laccase and a source of oxygen.

6. The composition of claim 1, which further comprises one or more enzymes selected from the group consisting of proteases, lipases, cutinases, amylases, carbohydrases, cellulases, pectinases, mannanases, arabinases, galactanases and xylanases.

7. The composition of claim 1, wherein the non-enzymatic biocides are capable of either:

(a) reducing the number of living cells of Escherichia coli (DSM

     1576) to 1/100 after 10 min. incubation at 20°

C. in an aqueous solution of 50%(w/w), or

(b) inhibiting the outgrowth of Escherichia coli (DSM1576) for 24 hours at 25°

C. in a microbial growth substrate, when added in a concentration of 1000 ppm.

8. The composition of claim 1, wherein the non-enzymatic biocides are selected from the group consisting of Benzoic acid, Sodium benzoate, benzylalcohol, Bronopol, Chlorhexidine, Chlorhexidine digluconate, Chlorhexidine diacetate, chlorhexidine di-hydrochloride, Chloroxylenol, Dehydroacetic acid, Sodium dehydroacetate, Dichlorobenzyl alcohol, Dimethylol di-methyl hydrantoin, Ethyl alcohol, Formaldehyde, Glutaraldehyde, Imidazolidinyl urea, Methylchloroisothiazolinone, Benzisothiazolinone, Methylisothiazolinone, methylparaben, ethylparabens, propylparabens, Butylparabens, Isopropylparabens, Isobutylparabens, Benzylparabens, Phenethyl alcohol, Phenoxyethanol, Quaternium-15, Sorbic acid, Potassium sorbate, Dimethyl hydroxymethyl pyrazole, lodopropyinyl butylcarbamate, Methenammonium chloride, Methyldibromo glutaronitrile, Polyquaternium-42, Sodium hydroxymethylglycinate, Benzalkonium chloride, Benzethonium Chloride, 5-Bromo-5-nitro-1,3-dioxane, Chloroacetamide, Chlorobutanol, Dimethoxane, Dimethyl Oxazolidine, 7-ethyl bicyclooxazolidine, Glutaral, Hexetidine, Phenylmercuric acetate, Thimersal, Ortho phenylphenol, Polyaminopropyl biguanide, Polymethoxy bicyclic oxazolidine, Salicylic acid, Sodium borate, Boric acid, Sodium iodate, Zinc pyrithione, Selenium disulfide, Piroctone Olamine, Triclosan, Triclocarban, Chloroxylenol, Zinc phenolsulfonate, essential oils or chelating agents like EDTA, polyphosphates, Pentetic acids, Hydroxyethyl ethylenediamine triacetic acid and Etidronic acid.

9. A method for killing or inhibiting microbial cells, comprising treating the microbial cells with the composition of claim 1.

10. A method for cleaning, disinfecting or inhibiting microbial growth on a hard surface, comprising contacting the hard surface with the composition of claim 1.

11. The method of claim 10, wherein the hard surface is a process equipment

12. The method of claim 11, wherein the hard surface is a member of a cooling tower, a water treatment plant, a dairy, a food processing plant, a chemical or pharmaceutical process plant.

13. The method of claim 11, wherein the hard surface is a surface of water sanitation equipment.

14. The method of claim 11, wherein the hard surface is a surface of equipment for pulp and paper processing.

15. A method for preserving a cosmetic product, comprising adding an effective amount of the composition of claim 1 into the cosmetic product.

16. The method of claim 15, wherein the cosmetic product is selected from the group consisting of a mouth wash composition, a cosmetic liquid or gel or paste, an eye lotion, a perspirant, a deodorant, a nasal spray, an eye ointment, an ointment or cream and a foot bath salt.

18. A detergent composition comprising a surfactant and the composition of claim 2.

17. A detergent composition comprising an enzymatic component, one or more non-enzymatic biocides, and a surfactant.