Signal delivery through the right ventricular septum

• US 20020032467A1
• Filed: 05/03/2001
• Published: 03/14/2002
• Est. Priority Date: 05/04/2000
• Status: Abandoned Application

• Current Assignee: Impulse Dynamics NV
• Original Assignee: Impulse Dynamics NV
• Inventors: Mika, Yival, Shemer, Itsik
• Application Number:
  US09/848,535
• Publication Number:
  US 20020032467A1
• Time in Patent Office: Days
• US Class Current: 607/2
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2017/0243 for immobilizing local areas of the heart, e.g. while it beats
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/6853 with a balloon
• CPC Class Codes: A61B 5/6856 with a distal loop
• CPC Class Codes: A61B 5/6858 with a distal basket, e.g. expandable basket
• CPC Class Codes: A61B 5/6859 with multiple distal splines
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3628 using sub-threshold or non-excitatory signals
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36557 : controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36564 : controlled by blood pressure
• CPC Class Codes: A61N 1/36585 : controlled by two or more physical parameters
• CPC Class Codes: A61N 1/36842 : Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 : Bi-ventricular stimulation

Abstract

Apparatus for applying a signal to a heart of a human subject is provided. The apparatus includes a set of one or more electrodes, adapted to be coupled to the right ventricular septum of the heart. A control unit of the apparatus is adapted to drive the electrode set to apply an Excitable-Tissue Control (ETC) signal to the septum. Preferably, the control unit is adapted to configure the signal to be capable of modifying contractility of a portion of the heart.

Claims

1. A method for applying a signal to a heart of a human subject, comprising applying an Excitable-Tissue Control (ETC) signal to a site on the right ventricular septum of the heart.

2. A method according to claim 1, wherein applying the ETC signal comprises configuring the signal to be capable of modifying contractility of a portion of the heart.

3. A method according to claim 2, wherein configuring the ETC signal comprises configuring the signal to be capable of modifying contractility of the left ventricle of the heart.

4. A method according to claim 2, wherein configuring the ETC signal comprises configuring the signal to be capable of modifying contractility of the septum.

5. A method according to claim 2, wherein configuring the ETC signal comprises configuring the signal to be capable of modifying contractility of the right ventricle of the heart.

6. A method according to claim 2, wherein configuring the ETC signal comprises configuring the signal to be capable of increasing contractility of the portion of the heart.

7. A method according to claim 2, wherein configuring the ETC signal comprises configuring the signal to be capable of decreasing contractility of the portion of the heart.

8. A method according to claim 7, wherein configuring the ETC signal to be capable of decreasing the contractility comprises configuring the signal to be capable of decreasing contractility of the septum.

9. A method according to claim 1, wherein applying the ETC signal comprises applying a series of biphasic pulses.

10. A method according to claim 1, wherein applying the ETC signal comprises applying a series of generally square pulses.

11. A method according to claim 1, wherein applying the ETC signal comprises applying a series of pulses at a rate greater than about 50 Hz.

12. A method according to claim 1, wherein applying the ETC signal comprises applying a series of pulses at a rate less than about 100 Hz.

13. A method according to claim 1, wherein applying the ETC signal comprises applying a series of pulses at a rate between about 50 Hz and 100 Hz.

14. A method according to claim 1, wherein applying the ETC signal comprises applying a series of pulses which are greater than about 8 mA.

15. A method according to claim 14, wherein applying the ETC signal comprises applying a series of pulses which are greater than about 10 mA.

16. A method according to claim 1, wherein applying the ETC signal comprises applying the ETC signal to a site at or adjacent to an intersection of the septum and the right ventricular free wall.

18. Apparatus according to claim 17, wherein the control unit is adapted to configure the signal to be capable of modifying contractility of a portion of the heart.

19. Apparatus according to claim 18, wherein the control unit is adapted to configure the signal to be capable of modifying contractility of the left ventricle of the heart.

20. Apparatus according to claim 18, the control unit is adapted to configure the signal to be capable of modifying contractility of the septum.

21. Apparatus according to claim 18, wherein the control unit is adapted to configure the signal to be capable of modifying contractility of the right ventricle of the heart.

22. Apparatus according to claim 18, wherein the control unit is adapted to configure the signal to be capable of increasing contractility of the portion of the heart.

23. Apparatus according to claim 18, wherein the control unit is adapted to configure the signal to be capable of decreasing contractility of the portion of the heart.

24. Apparatus according to claim 23, wherein the control unit is adapted to configure the signal to be capable of decreasing contractility of the septum.

25. Apparatus according to claim 17, wherein the control unit is adapted to drive the elect rode s et to apply a series of biphasic pulses.

26. Apparatus according to claim 17, wherein the control unit is adapted to drive the electrode set to apply a series of generally square pulses.

27. Apparatus according to claim 17, wherein the control unit is adapted to drive the electrode set to apply a series of pulses at a rate greater than about 50 Hz.

28. Apparatus according to claim 17, wherein the control unit is adapted to drive the electrode set to apply a series of pulses at a rate less than about 100 Hz.

29. Apparatus according to claim 17, wherein the control unit is adapted to drive the electrode set to apply a series of pulses at a rate between about 50 Hz and 100 Hz.

30. Apparatus according to claim 17, wherein the control unit is adapted to drive the electrode set to apply a series of pulses which are greater than about 8 mA.

31. Apparatus according to claim 30, wherein the control unit is adapted to drive the electrode set to apply a series of pulses which are greater than about 10 mA.

32. Apparatus according to claim 17, wherein the control unit is adapted to drive the electrode set to apply the ETC signal to a site at or adjacent to an intersection of the septum and the right ventricular free wall.

17. Apparatus for applying a signal to a heart of a human subject, comprising:

a set of one or more electrodes, adapted to be coupled to the right ventricular septum of the heart; and

a control unit, adapted to drive the electrode set to apply an Excitable-Tissue Control (ETC) signal to the septum.