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Integrated optic waveguide immunosensor

  • US 20020034457A1
  • Filed: 10/10/2001
  • Published: 03/21/2002
  • Est. Priority Date: 02/23/1995
  • Status: Active Grant
First Claim
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1. An apparatus for performing a specific binding assay, the apparatus comprising:

  • a composite waveguide comprising;

    a substrate comprising a first optical material of refractive index n1 and having a first planar surface and an opposite second surface separated by a thickness and a surrounding edge, and a waveguide film comprising a second optical material having a refractive index n2 which is greater than n1, said waveguide film disposed on said first planar surface of said substrate;

    capture molecules, associated with said waveguide film, for interacting selectively with at least one type of selected analyte molecule;

    a light source operably disposed to direct a light beam into said composite waveguide for propagation by total internal reflection therein;

    a light detection device positioned in a cone of collection angles, said cone of collection angles having an axis oriented substantially orthogonal to a plane of said waveguide film.

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