Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
First Claim
1. A kit for treating a disease in a patient in need thereof, comprising a catheter means and a solution which contains an enzyme of mild detergent, wherein:
- (i) said catheter means is adapted for insertion into a blood vessel and comprises a main catheter body having means including a balloon element adapted to be inserted into said vessel and expansible against the walls of said vessel so as to hold said main catheter body in place in said vessel, and means carried by said main catheter body for delivering a solution into said blood vessel; and
(ii) said solution is a physiologically acceptable solution;
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Abstract
A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique, provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
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Citations
32 Claims
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1. A kit for treating a disease in a patient in need thereof, comprising a catheter means and a solution which contains an enzyme of mild detergent, wherein:
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(i) said catheter means is adapted for insertion into a blood vessel and comprises a main catheter body having means including a balloon element adapted to be inserted into said vessel and expansible against the walls of said vessel so as to hold said main catheter body in place in said vessel, and means carried by said main catheter body for delivering a solution into said blood vessel; and
(ii) said solution is a physiologically acceptable solution;
- View Dependent Claims (2, 3, 4, 5)
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6. A kit for treating a disease in a patient in need thereof, comprising a catheter means and a physiologically acceptable solution, wherein;
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(i) said catheter means is adapted for insertion into a blood vessel and comprises a main catheter body having means including a balloon element, adapted to be inserted in said blood vessel and being expansible against the walls of said vessel so as to hold said main catheter body in place, and means carried by said main catheter body for delivering a solution into said blood vessel;
(ii) said physiologically acceptable solution comprises at least one member selected from the group consisting of heparin, poly-L-lysine, polybrene, dextransulfate, a polycationic material, and bivalent antibodies. - View Dependent Claims (7, 8)
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- 9. A method for treating a disease in a patient in need thereof, comprising causing a cell attached onto the walls of a vessel or in an organ or tissue in said patient to express an exogeneous therapeutic agent protein, wherein said protein treats said disease.
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14. A method for treating a disease, comprising site-specifically instilling cells.
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17. A method for treating a disease, in a patient comprising site-specifically transforming cells in vivo.
Specification