Optical imaging system with symmetric optical probe

• US 20020037095A1
• Filed: 02/06/2001
• Published: 03/28/2002
• Est. Priority Date: 08/04/2000
• Status: Active Grant

• Current Assignee: ViOptix, Inc.
• Original Assignee: ViOptix, Inc.
• Inventors: Cheng, Xuefeng
• Granted Patent: US 6,801,648 B2
• Time in Patent Office: Days
• US Class Current: 382/134
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/0242 for varying or adjusting the optical path length in the tissue
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 21/3563 for analysing solids; Preparation of samples therefor
• CPC Class Codes: G01N 21/359 using near infrared light
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

The present invention generally relates to optical probes of optical imaging systems and methods thereof for providing two-or three-dimensional images of spatial or temporal distribution of chromophores and/or their properties in a physiological medium. More particularly, the present invention relates to optical probes of optical imaging systems equipped with optical sensors such as wave sources and wave detectors which are disposed on scanning surfaces of the optical probes in a symmetric fashion. A typical optical probe of the present invention includes at least two wave sources (a first wave source and a second wave source) as well as at least two wave detectors (a first wave detector and a second wave detector), where the first wave source is disposed closer to the first wave detector than the second wave detector, and where the second wave source is disposed closer to the second wave detector than the first wave detector. More particularly, the foregoing wave sources and detectors are arranged so that a first near-distance between the first wave source and the first wave detector is substantially similar or identical to a second near-distance between the second wave source and the second wave detector, and that a first far-distance between the first wave source and the second wave detector is substantially identical or similar to a second far-distance between the second wave source and the first wave detector. The near-distance is preferably one half of the far-distance but may be longer or shorter than the far-distance. Each pair of one of the wave sources and one of the wave detectors is arranged to generate the output signal.

Claims

1. An optical probe for an optical imaging system capable of generating images representing distribution of hemoglobins or their properties in target areas of a physiological medium, said optical probe including a plurality of wave sources and wave detectors, said wave sources configured to form optical coupling with said medium and to irradiate near-infrared electromagnetic waves thereinto and said wave detectors configured to detect said near-infrared electromagnetic waves and configured to generate output signals in response thereto, said optical probe comprising:

a plurality of symmetrically disposed scanning units each of which including a first wave source, a second wave source, a first wave detector, and a second wave detector, said first wave source disposed closer to said first wave detector than said second wave detector and said second wave source disposed closer to said second wave detector than said first wave detector, wherein a first near-distance between said first wave source and said first wave detector is substantially similar to a second near-distance between said second wave source and said second wave detector, wherein a first far-distance between said first wave source and said second wave detector is substantially similar to a second far-distance between said second wave source and said first wave detector, and wherein said first and second wave detectors are configured to generate said output signals in response to said near-infrared electromagnetic waves irradiated by at least one of said first and second wave sources and detected thereby, said output signals representing optical interaction of said near-infrared electromagnetic waves with said hemoglobins in said target areas of said medium.

2. The optical probe of claim 1 wherein said first and second near-distances are at least substantially identical.

3. The optical probe of claim 1 wherein said first and second far-distances are at least substantially identical.

4. The optical probe of claim 1 wherein at least one of said symmetric scanning units includes an axis of symmetry with respect to which said first and second wave sources are symmetrically disposed and with respect to which said first and second wave detectors are symmetrically disposed.

5. The optical probe of claim 4 wherein at least two of said symmetric scanning units include at least one of a common wave source and a common wave detector.

6. The optical probe of claim 4 wherein said first and second wave sources and said first and second wave detectors are substantially linearly disposed.

7. The optical probe of claim 6 wherein said first and second wave sources are interposed between said first and second wave detectors.

8. The optical probe of claim 6 wherein said first and second wave detectors are interposed between said first and second wave sources.

9. The optical probe of claim 6 wherein said near-distance is about one half of said far-distance.

10. The optical probe of claim 6 wherein said optical probe includes at least one first symmetric scanning unit and at least one second symmetric scanning unit, wherein said first and second scanning units share said axis of symmetry, wherein said first scanning unit has a first arrangement of said wave sources and wave detectors, and wherein said second scanning unit has said first arrangement of said wave sources and detectors and is disposed below said first scanning unit.

11. The optical probe of claim 10 wherein said second scanning unit is disposed immediately below said first scanning unit.

12. The optical probe of claim 6 wherein said optical probe includes at least one first symmetric scanning unit and at least one second symmetric scanning unit, wherein said first and second scanning units share said axis of symmetry, wherein said first scanning unit has a first arrangement of said wave sources and wave detectors, and wherein said second scanning unit is disposed below said first scanning unit and has a second arrangement of said wave sources and wave detectors that is substantially reverse to said first arrangement.

13. The optical probe of claim 12 wherein said second scanning unit is disposed immediately below said first scanning unit.

14. The optical probe of claim 6 wherein said optical probe includes at least one first, second, third, and fourth symmetric scanning units each sharing said axis of symmetry with the others, wherein said first scanning unit has a first arrangement of said wave sources and wave detectors, wherein said second scanning unit is disposed immediately below said first scanning unit and has a second arrangement of said wave sources and wave detectors which is substantially reverse to said first arrangement, wherein said third scanning unit is disposed immediately below said second scanning unit and has said second arrangement, and wherein said fourth scanning unit is disposed immediately below said third scanning unit and has said first arrangement.

15. The optical probe of claim 14 wherein all of said symmetric scanning units have identical shapes and sizes and define a 4×

4 source-detector arrangement wherein said wave sources and detectors of said symmetric scanning units are spaced at a uniform distance.

16. The optical probe of claim 15 wherein said 4×

4 source-detector arrangement has a shape of a quadrangle which is one of a rectangle, a square, a parallelogram, and a diamond.

17. The optical probe of claim 4 wherein said first and second wave sources and said first and second wave detectors are arranged to form four vertices of a quadrangle, said first and second wave sources disposed at two upper vertices of said quadrangle, and said first and second wave detectors disposed at two lower vertices thereof.

18. The optical probe of claim 17 wherein said quadrangle is one of a trapezoid, rectangle, and square, said trapezoid having two opposing sides of equal lengths.

19. The optical probe of claim 17 wherein said optical probe includes at least one first symmetric scanning unit and at least one second symmetric scanning units, said first and second scanning units having different axes of symmetry, said first scanning unit having a first arrangement of said wave sources and detectors, and said second scanning unit disposed lateral to said first scanning unit and having said first arrangement.

20. The optical probe of claim 17 wherein said optical probe includes at least one first symmetric scanning unit and at least one second symmetric scanning units, said first and second scanning units having different axes of symmetry, said first scanning unit having a first arrangement of said wave sources and detectors, and said second scanning unit disposed lateral to said first scanning unit and having a second arrangement of said wave sources and detectors which is substantially reverse to said first arrangement.

21. The optical probe of claim 17 wherein said optical probe includes at least one first, second, third, and fourth symmetric scanning units, wherein said first scanning unit has a first arrangement of said wave sources and detectors, wherein said second scanning unit is disposed lateral to said first scanning unit and has a second arrangement of said wave sources and detectors which is substantially reverse to said first arrangement, wherein said third scanning unit is disposed immediately below said first scanning unit and has said second arrangement, and wherein said fourth scanning unit is disposed immediately below said second scanning unit and has said first arrangement.

22. The optical probe of claim 4 wherein a first set of said wave sources and detectors is substantially linearly disposed and wherein a second set of said wave sources and detectors is disposed to form four vertices of a quadrangle.

23. The optical probe of claim 22 wherein said first and second sets include at least one of a common wave source and a common wave detector.

24. The optical probe of claim 1 wherein at least one of said symmetric scanning units includes a point of symmetry with respect to which said first and second wave sources are symmetrically disposed and with respect to which said first and second wave detector are symmetrically disposed.

25. The optical probe of claim 24 wherein at least two of said symmetric scanning units include at least one of a common wave source and a common wave detector.

26. The optical probe of claim 24 wherein said first and second wave sources and said first and second wave detectors are substantially linearly disposed.

27. The optical probe of claim 24 wherein said first and second wave sources and said first and second wave detectors are disposed to form four vertices of a quadrangle, wherein said first wave source and detector are disposed at two upper vertices of said quadrangle, and wherein said second wave detector and source are disposed at two lower vertices thereof.

28. The optical probe of claim 27 wherein said quadrangle is one of a rectangle and a parallelogram, said parallelogram having two sides of different lengths.

29. The optical probe of claim 1 wherein at least one of said symmetric scanning units includes at least one of a third wave source and a third wave detector.

30. The optical probe of claim 29 wherein at least one of said third wave source and detector is disposed in a substantially middle portion of said symmetric scanning unit.

31. The optical probe of claim 1 wherein at least two of said symmetric scanning units are arranged symmetrically with respect to a global axis of symmetry.

32. The optical probe of claim 31 wherein at least one of said symmetric scanning units is disposed immediately below the other of said symmetric scanning units.

33. The optical probe of claim 31 wherein at least two of said symmetric scanning units are substantially laterally arranged.

34. The optical probe of claim 1 wherein at least two of said symmetric scanning units are arranged symmetrically with respect to a global point of symmetry.

35. The optical probe of claim 34 wherein at least two of said symmetric scanning units are arranged substantially arcuately around said point of symmetry.

36. The optical probe of claim 34 wherein at least two of said symmetric scanning units are arranged substantially concentrically around said point of symmetry.

37. The optical probe of claim 1 wherein at least one of said wave sources is configured to irradiate multiple sets of electromagnetic waves having different wave characteristics.

38. The optical probe of claim 1 wherein at least one of said wave detectors is configured to detect a plurality of sets of electromagnetic waves having different wave characteristics.

39. The optical probe of claim 1 wherein one of said wave sources is arranged to irradiate electromagnetic waves while at least one of said wave sources is not irradiating electromagnetic waves.

40. The optical probe of claim 1 wherein said electromagnetic waves are at least one of sound waves, near-infrared rays, infrared rays, visible lights, ultraviolet rays, lasers, and photons.

41. The optical probe of claim 1 wherein said images represent at least one of two-dimensional and three-dimensional distribution of at least one of said hemoglobins and said properties thereof.

42. The optical probe of claim 1 wherein said properties represent at least one of spatial distribution and temporal variation in at least one of said hemoglobins and said properties thereof.

43. The optical probe of claim 1 wherein said properties are at least one of absolute values and relative values of at least one of said hemoglobins and said properties thereof.

44. The optical probe of claim 1 wherein said properties include at least one of concentration of deoxygenated hemoglobin, concentration of oxygenated hemoglobin, and an oxygen saturation which is a ratio of said concentration of said oxygenated hemoglobin to a sum of said concentrations of said oxygenated hemoglobin and said deoxygenated hemoglobin.

45. The optical probe of claim 1 wherein said properties are extensive properties including at least one of volume, mass, weight, volumetric flow rate, and mass flow rate of said hemoglobins.

47. The optical probe of claim 46 wherein all of said wave sources and all of said wave detectors of each of said scanning units are substantially linearly disposed.

48. The optical probe of claim 47 wherein said first and second wave sources are interposed between said first and second wave detectors in said first and fourth scanning units and wherein said first and second wave detectors are interposed between said first and second wave sources in said second and third scanning units.

50. The optical probe of claim 49 wherein said first and second scanning units are configured to intersect each other.

51. The optical probe of claim 49 further comprising:

an imaging member configured to receive said first and second output signals generated by said first and second wave detectors, to obtain a set of solutions of a plurality of wave equations applied to said first and second wave sources and to said first and second wave detectors, to determine said distribution of at least one of hemoglobins and properties thereof, and to generate said images of said distribution.

52. The optical probe of claim 51 wherein said images are generated in an image domain, wherein said images are comprised of a plurality of voxels, wherein each of said first and second scanning units generates a plurality of first voxels and a plurality of second voxels, respectively, and wherein said imaging member is configured to calculate at least one first voxel value for each of said first voxels from said set of said solutions and at least one second voxel value for each of said second voxels from said set of said solutions.

53. The optical probe of claim 52 wherein said imaging member is configured to define a plurality of cross-voxels each of which is defined as an overlapping portion of said first and second voxels intersecting each other.

54. The optical probe of claim 53 wherein said imaging member is configured to calculate at least one cross-voxel value for each of said cross-voxels directly from said first and second voxel values of said intersecting first and second voxels, respectively.

55. The optical probe of claim 54 wherein each of said cross-voxel values is at least one of an arithmetic sum and arithmetic average of said first and second voxel values of said first and second voxels intersecting each other.

56. The optical probe of claim 54 wherein each of said cross-voxel values is at least one of a weighted sum and weighted average of said first and second voxel values of said first and second voxels intersecting each other.

58. The method of claim 57 further comprising:

scanning said target area over time;

determining said distribution of at least one of hemoglobins and properties thereof in said target area of said medium over time;

providing said images of said distribution over time; and

providing said images of changes in said distribution over time.

59. The method of claim 57 further comprising:

defining a plurality of first voxels in at least one of said scanning units;

determining at least one first voxel value for each of said first voxels, each of said first voxel values representing an average value of at least one of said hemoglobins and said properties thereof; and

generating said images of said distribution directly from said first voxel values.

60. The method of claim 59 wherein said defining comprises:

controlling resolution of said images by adjusting at lease one characteristic dimension of each of said first voxels.

61. The method of claim 60 wherein said controlling comprises at least one of:

adjusting at least one distance between at least one of said wave sources and at least one of said wave detectors of at least one of the same scanning element and the same scanning unit;

adjusting geometric arrangement between at least one of said wave sources and at least one of said wave detectors of at least one of the same scanning element and the same scanning unit;

adjusting geometric arrangement between at least two scanning elements of the same scanning unit;

adjusting geometric arrangement between at least two scanning units; and

adjusting data sampling rate of said output signals.

62. The method of claim 59 further comprising:

defining a plurality of second voxels in at least one of said scanning units;

determining at least one second voxel value for each of said second voxels, each second voxel value representing an average value of at least one of said hemoglobins and said properties thereof; and

generating said images of said distribution directly from said first and second voxel values.

63. The method of claim 62 further comprising:

defining a plurality of cross-voxels in at least one of said scanning units, each of said cross-voxels defined as an overlapping portion of two intersecting first and second voxels;

determining at least one cross-voxel value for each of said cross-voxels, each cross-voxel value representing an average value of at least one of said hemoglobins and said properties thereof; and

generating said images of said distribution directly from said cross-voxel values and at least one of said first and second voxel values.

64. The method of claim 63 wherein said cross-voxel values are determined by at least one of:

adding said first and second voxel values of said intersecting first and second voxels;

arithmetically averaging said first and second voxel values of said intersecting first and second voxels;

adding weighted first and second voxel values of said intersecting first and second voxels; and

weight-averaging said first and second voxel values of said intersecting first and second voxels.

65. The method of claim 62 further comprising:

defining a plurality of third voxels in at least one of said scanning units;

determining at least one third voxel value for each of said third voxels, each third voxel value representing an average value of at least one of said hemoglobins and said properties thereof;

generating said images of said distribution directly from said first, second, and third voxel values.

66. The method of claim 65 further comprising:

defining a plurality of second cross-voxels in at least one of said scanning units, each of said second cross-voxels defined as an overlapping portion of two intersecting first and third voxels;

determining at least one second cross-voxel value for each of said second cross-voxels, each second cross-voxel value representing an average value of at least one of said hemoglobins and said properties thereof; and

generating said images of said distribution based on at least one of said cross-voxel values, second cross-voxel values, first voxel values, second voxel values, and third voxel values.

46. An optical probe of an optical imaging system capable of generating images representing distribution of hemoglobins or their properties in target areas of a physiological medium, said optical probe including a plurality of wave sources and a plurality of wave detectors, said wave sources configured to form optical coupling with said medium and to irradiate near-infrared electromagnetic waves thereinto and said wave detectors configured to detect said near-infrared electromagnetic waves and configured to generate output signals in response thereto, said optical probe comprising:

four symmetric scanning units wherein a first scanning unit is identical to a fourth scanning unit and wherein a second scanning unit is identical to a third scanning unit, each of said symmetric scanning units including a first wave source, a second wave source, a first wave detector, and a second wave detector, wherein said first wave source is disposed closer to said first wave detector than said second wave detector and wherein said second wave source is disposed closer to said second wave detector than said first wave detector, wherein a first near-distance between said first wave source and first wave detector is arranged to be substantially similar to a second near-distance between said second wave source and second wave detector, wherein a first far-distance between said first wave source and second wave detector is arranged to be substantially similar to a second far-distance between said second wave source and first wave detector, and wherein said first and second wave sources are configured to be synchronized with said first and second wave detectors to generate said output signals which represent optical interaction of said near-infrared waves with said hemoglobins in said target areas of said medium.

49. An optical probe of an optical imaging system capable of generating images representing distribution of hemoglobins or their properties in target areas of a physiological medium, said optical probe including a plurality of wave sources and a plurality of wave detectors, said wave sources configured to form optical coupling with said medium and to irradiate near-infrared electromagnetic waves thereinto and said wave detectors configured to detect said near-infrared electromagnetic waves and configured to generate output signals in response thereto, said optical probe comprising:

a plurality of wave sources; and

a plurality of wave detectors,

wherein at least one first wave source and at least one first wave detector define a first scanning element in which said first wave source irradiates said near-infrared electromagnetic waves and said first wave detector detects said waves irradiated by said first wave detector and generates a first output signal, wherein at least one second wave source and at least one second wave detector define a second scanning element in which said second wave source irradiates said near-infrared electromagnetic waves and said second wave detector detects said waves irradiated by said second wave detector and generates a second output signal, wherein said first and second scanning elements define a scanning unit in which said first and second wave sources are symmetrically disposed with respect to one of a line of symmetry and a point of symmetry and in each of which said first and second wave detectors are also symmetrically disposed with respect to one of said line of symmetry and said point of symmetry.

57. A method for generating two-dimensional or three-dimensional images of a target area of a physiological medium by an optical imaging system with an optical probe, said images representing spatial or temporal distribution of hemoglobins or their properties in said medium, wherein said optical probe includes a plurality of wave sources and a plurality of wave detectors, said wave sources configured to form optical coupling with said target area of said medium and to irradiate near-infrared electromagnetic waves thereinto, said wave detector configured to form optical coupling with said target area of said medium and to generate output signals in response to said near-infrared electromagnetic waves detected thereby, said image generating method comprising the steps of:

providing a plurality of scanning elements each of which includes at least one of said wave sources for irradiating said waves and at least one of said wave detectors for detecting said waves irradiated by said at least one of said wave sources of said each of said scanning unit;

defining a plurality of scanning units each of which includes at least two of said scanning elements and, therefore, each of which includes at least two of said wave sources and at least two of said wave detectors;

scanning said target area by irradiating electromagnetic waves thereinto by said wave sources and by generating said output signals therefrom by said wave detectors;

grouping output signals generated by each of said scanning units;

obtaining a set of solutions of wave equations applied to said wave sources and detectors of each of said scanning units;

determining said distribution of at least one of hemoglobins and properties thereof from said set of solutions; and

providing said images of said distribution.