Self-assembled thin film coating to enhance the biocompatibility of materials
First Claim
1. A process of making a substrate biocompatible comprising the steps of:
- contacting at least a portion of a charged substrate with an oppositely charged starting material and by electrostatic self-assembly constructing a multi-layered film of alternating charged molecular layers on the substrate, wherein the starting material is selected from the group consisting of;
poly(vinylpyrrolidone), poly{bis(carboxylatophenoxy)phosphazene}, poly(methacrylic acid) poly(l-lysine), poly(ethylene glycol), poly(D-glucosamine), poly(l-glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene and long-sidechain fullerene.
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Accused Products
Abstract
We make a substrate biocompatible by contacting it with a starting material and initiating alternating charge layer electrostatic self-assembly to form a thin film. Starting materials may be poly(vinylpyrrolidone), poly{bis-(carboxylatophenoxy)phosphazene}, poly(methacrylic acid), poly(l-lysine), poly(ethylene glycol), poly(D-glucosamine), poly(l-glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene, long-sidechain fullerene, or other polymers that participate in electrostatic self-assembly. The thin film fabrication advantageously may be at room temperature. A biocompatible thin film that is uniform and homogeneous can be provided. Optionally, ZrO2, Al2O3 or TiO2 nanoclusters also may be used in the film assembly. The film may be used in a drug delivery device or a medical device. The film may be used for tissue engineering. We also provide a biocompatible composition in which are present a plurality of layers electrostatically self-assembled from at least a polymer or fullerene as mentioned. The substrate is not particularly limited, and may be quartz, glass, plastic, metal or ceramic, a material for a bone implant, bioactive glass, polyester or other polymers, plastic or rubber tubing, bandaging material, composite material, insulator material, semi-conductor material, an artificial hip, a pacemaker, a catheter, a stent or other substrates.
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Citations
87 Claims
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1. A process of making a substrate biocompatible comprising the steps of:
contacting at least a portion of a charged substrate with an oppositely charged starting material and by electrostatic self-assembly constructing a multi-layered film of alternating charged molecular layers on the substrate, wherein the starting material is selected from the group consisting of;
poly(vinylpyrrolidone), poly{bis(carboxylatophenoxy)phosphazene}, poly(methacrylic acid) poly(l-lysine), poly(ethylene glycol), poly(D-glucosamine), poly(l-glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene and long-sidechain fullerene. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 20, 21, 22, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
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18. A biocompatible composition consisting essentially of a plurality of layers electrostatically self-assembled from a starting material selected from the group consisting of:
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poly(vinylpyrrolidone), poly{bis(carboxylatophenoxy)phosphazene}, poly(methacrylic acid) poly(l-lysine), poly(ethylene glycol), poly(D-glucosamine), poly(I-glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene and long-sidechain fullerene.
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19. A biocompatible composition comprising a plurality of layers electrostatically self-assembled from a starting material selected from the group consisting of:
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poly(vinylpyrrolidone), poly{bis(carboxylatophenoxy)phosphazene}, poly(methacrylic acid) poly(l-lysine), poly(ethylene glycol), poly(D-glucosamine), poly(l-glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene and long-side chain fullerene.
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23. A biocompatible medical device or drug delivery device comprising:
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a substrate; and
, provided on the substrate,a thin film electrostatically self-assembled starting with a solution of at least one starting material selected from the group consisting of;
poly(vinylpyrrolidone), poly{bis(carboxylatophenoxy)phosphazene}, poly(methacrylic acid), poly(l-lysine), poly(ethylene glycol), poly(D-glucosamine), poly(l-glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene and long-side chain fullerene.
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56. A process of making a substrate biocompatible comprising the steps of:
contacting at least a portion of a charged substrate with an oppositely charged starting material and by electrostatic self-assembly constructing a multi-layered film of alternating charged molecular layers on the substrate, wherein the starting material is a polymer.
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73. A biocompatible material consisting essentially of a plurality of layers electrostatically self-assembled from a starting material that is a polymer.
- 74. A biocompatible material comprising a plurality of layers electrostatically self-assembled from a starting material that is a polymer.
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78. A biocompatible medical device or drug delivery device comprising:
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a substrate; and
, provided on the substrate,a thin film electrostatically self-assembled starting with a solution of at least one starting material that is a polymer.
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83. A device for contacting a biological material, comprising
a substrate; - and
a multilayered coating positioned on at least a portion of a surface of said substrate wherein adjacent layers of said multilayered coating are held together by ionic attraction, and wherein at least one layer of said multilayered coating is made from a material that is relatively more biocompatible than a substrate material in said substrate, whereby said multilayer coating renders the device biocompatible with said biological material. - View Dependent Claims (84, 85, 86)
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87. A method of rendering a device biocompatible with a biological material, comprising the step of applying a multilayered coating on at least a portion of a surface of a substrate wherein adjacent layers of said multilayered coating are held together by ionic attraction, and wherein at least one layer of said multilayered coating is made from a material that is relatively more biocompatible than a substrate material in said substrate.
Specification