Method and apparatus for minimizing spectral effects attributable to tissue state variations during NIR-based non-invasive blood analyte determination
First Claim
1. A method for controlling spectral effects attributable to tissue state variations during NIR-based, non-invasive blood analyte determination, comprising the steps of:
- determining a target range of values for a selected tissue state parameter;
providing means for modifying said tissue state parameter;
providing a calibration model that correlates said spectral effects to variations in said tissue state parameter;
monitoring said tissue state parameter by measuring an NIR spectrum and calculating values for said parameter from said spectrum according to said calibration model; and
if said calculated value is outside of said target range, modifying said tissue state parameter until a measured value for said parameter is within said target range.
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Abstract
A method and apparatus for minimizing confounding effects in a noninvasive in-vivo spectral measurement caused by fluctuations in tissue state monitors a selected tissue state parameter spectroscopically and maintains the selected parameter within a target range, at which spectral effects attributable to the changes in the selected parameter are minimized. The invention includes means for both active and passive control.
A preferred embodiment of the invention provides a method and apparatus for minimizing the confounding effects in near IR spectral measurements attributable to shifts in skin temperature at a tissue measurement site. Spectroscopic monitoring of skin temperature at the measurement site provides near-instantaneous temperature readings by eliminating thermal time constants. A thermistor positioned at the measurement site provides active control. The spectrometer and the temperature control device are incorporated into a single instrument for noninvasive measurement of blood glucose concentration.
60 Citations
46 Claims
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1. A method for controlling spectral effects attributable to tissue state variations during NIR-based, non-invasive blood analyte determination, comprising the steps of:
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determining a target range of values for a selected tissue state parameter;
providing means for modifying said tissue state parameter;
providing a calibration model that correlates said spectral effects to variations in said tissue state parameter;
monitoring said tissue state parameter by measuring an NIR spectrum and calculating values for said parameter from said spectrum according to said calibration model; and
if said calculated value is outside of said target range, modifying said tissue state parameter until a measured value for said parameter is within said target range. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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23. An apparatus for controlling spectral effects attributable to tissue state variations during NIR-based, non-invasive blood analyte determination, comprising:
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means for modifying a selected tissue state parameter;
means for measuring an NIR spectrum at a tissue measurement site;
a calibration model that correlates said spectral effects to variations in said tissue state parameter;
means for monitoring said tissue state parameter by measuring an NIR spectrum and calculating values for said parameter from said spectrum according to said calibration model;
wherein said tissue state parameter is modified by said modifying means if said calculated value is outside of a target range until said parameter is within said target range.
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Specification