Vitamin D derivative having substituent at 2beta-position

• US 20020045772A1
• Filed: 10/17/2001
• Published: 04/18/2002
• Est. Priority Date: 04/10/1998
• Status: Abandoned Application

• Current Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
• Original Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
• Inventors: Watanabe, Hiroyoshi
• Application Number:
  US09/978,084
• Publication Number:
  US 20020045772A1
• Time in Patent Office: Days
• US Class Current: 552/502
• CPC Class Codes: C07C 401/00 Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
• CPC Class Codes: C07J 71/0042 Nitrogen only
• CPC Class Codes: C07J 9/00 Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
• CPC Class Codes: Y02P 20/55 Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A steroid intermediate has the formula (II):

wherein A denotes alkylene of 2 to 10 carbons; X denotes halogen; R_a, R_b and R_c denote, independently hydrogen or hydroxyl protecting group; and R_p, R_q, R_y and R_z are such that R_p and R_q together form a double bond between the 5-position and the 6-position and R_y and R_z together form a double bond between the 7-position and the 8-position, or R_q and R_y together form a double bond between the 6-position and the 7-position and R_p and R_z are bound to a dienophile capable of protecting conjugated double bonds.

Claims

1. A steroid compound of the general formula (II)

2. A steroid compound as claimed in claim 1, wherein A is a straight chain alkylene group with 2 to 10 carbon atoms;

and X is an iodine atom.