Modulation of nitric oxide synthase by PKC
First Claim
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1. A method of modulating endothelial cell nitric oxide synthase (eNOS) in a cell, tissue, or subject, comprising modulating a PKC β
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Abstract
Featured are methods of modulating endothelial NOS (eNOS) expression, e.g., insulin-stimulated eNOS expression, by modulating PKCβ. The methods are useful in the treatment of insulin-related disorders, e.g., hypertension.
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Citations
26 Claims
- 1. A method of modulating endothelial cell nitric oxide synthase (eNOS) in a cell, tissue, or subject, comprising modulating a PKC β
- 10. A method of increasing eNOS in a cell, tissue, or subject, comprising inhibiting a PKCβ
- 20. A method of increasing eNOS in a cell, tissue, or subject, comprising increasing a PI3 kinase activity.
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24. A method of treating hypertension in a subject, comprising:
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identifying a subject in need of treatment for hypertension; and
administering LY333531, wherein LY333531 increases eNOS expression in a tissue of the subject.
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25. A method of determining if a subject is at risk for hypertension, comprising:
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evaluating a PKCβ
activity in a cell or tissue of the subject,comparing the PKCβ
activity in the cell or tissue of the subject to a control.
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Specification