Capillary array-based sample screening
First Claim
11. A capillary for screening a sample, wherein the capillary is adapted for being held in an array of capillaries, the capillary comprising:
- a first wall defining a lumen for retaining the sample, wherein the first wall forms a waveguide for propagating detectable signals therein; and
a second wall formed of a filtering material, for filtering excitation energy provided to the lumen to excite the sample.
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Accused Products
Abstract
A sample screening platform, system and method for screening and recovery of detectable samples. The platform includes a capillary array including a plurality of capillaries. Each capillary includes at least one wall defining a lumen for retaining the detectable sample. The detectable sample is introduced to and retained in the lumen by capillary forces. In a method of incubating the sample, a second liquid is introduced into the capillary containing the sample. A detection and recovery system includes an optical system for detecting the sample, and a recovery mechanism adapted to contact a capillary containing the sample. The recovery mechanism is further adapted to recover the sample from the capillary, and expel the recovered sample for analysis.
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Citations
42 Claims
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11. A capillary for screening a sample, wherein the capillary is adapted for being held in an array of capillaries, the capillary comprising:
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a first wall defining a lumen for retaining the sample, wherein the first wall forms a waveguide for propagating detectable signals therein; and
a second wall formed of a filtering material, for filtering excitation energy provided to the lumen to excite the sample. - View Dependent Claims (12, 13, 14, 16, 17, 18, 19, 20)
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15. A capillary array for screening a plurality of samples, comprising:
a plurality of capillaries, held together into the array, wherein each capillary includes a first wall defining a lumen for retaining the sample, and a second wall circumscribing the first wall, for filtering excitation energy provided to the lumen to excite the sample.
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21. A method for incubating a bioactivity or biomolecule of interest, comprising:
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introducing a first component into at least a portion of a capillary of a capillary array, wherein each capillary of the capillary array comprises at least one wall defining a lumen for retaining the first component;
introducing air into the capillary behind the first component; and
introducing a second component into the capillary, wherein the second component is separated from the first component by the air. - View Dependent Claims (22, 23, 24, 25, 26, 28, 29, 30)
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27. A method of incubating a sample of interest, comprising:
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introducing a first liquid labeled with a detectable particle into a capillary of a capillary array, wherein each capillary of the capillary array comprises at least one wall defining a lumen for retaining the liquid and the detectable particle;
submersing one end of the capillary into a fluid bath containing a second liquid; and
evaporating the first liquid from the opposite end of the capillary to draw the second liquid into the capillary tube.
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31. A method of incubating a sample of interest, comprising:
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introducing a first liquid labeled with a detectable particle into a capillary of a capillary array, wherein each capillary of the capillary array comprises at least one wall defining a lumen for retaining the first liquid and the detectable particle, and wherein the at least one wall is coated with a binding material for binding the detectable particle to the at least one wall;
removing the first liquid from the capillary tube, wherein the bound detectable particle is maintained within the capillary; and
introducing a second liquid into the capillary tube. - View Dependent Claims (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 32, 33, 35, 36, 38, 39, 40, 41, 42)
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34. A method of incubating a sample of interest, comprising:
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introducing a liquid labeled with a detectable particle into a capillary of a capillary array, wherein each capillary of the capillary array comprises at least one wall defining a lumen for retaining the liquid and the detectable particle;
introducing paramagnetic beads to the liquid; and
exposing the capillary containing the paramagnetic beads to a magnetic field to cause movement of the paramagnetic beads in the liquid within the capillary.
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36-1. The method of claim 34, further comprising removing, with the recovery tool, the sample from the capillary containing the sample.
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37. A recovery apparatus for a sample screening system, wherein the system
includes a plurality of capillaries formed into an array, the apparatus comprising: - a recovery tool adapted to contact at least one capillary of the capillary array and recover a sample therefrom;
an ejector, connected with the recovery tool, for ejecting the recovered sample from the recovery tool.
- a recovery tool adapted to contact at least one capillary of the capillary array and recover a sample therefrom;
Specification