Multi-spectral fluorescence imaging and spectroscopy device
First Claim
1. An optical device for illuminating a target area and detecting electromagnetic radiation reflected or emitted by fluorescence from said target area, comprising:
- a light source and filter means for transmitting selected wavelengths of electromagnetic radiation emitted from said light source;
a housing including first optical focusing means for shaping and directing a first light beam containing said selected wavelengths along a first optical path and focusing said light beam onto a selected surface area of a target area located a selected distance from said housing;
a detection means for detecting light; and
said housing including second optical focusing means for shaping and directing electromagnetic radiation reflected or emitted from said target area as a second light beam along a second optical path and focusing said electromagnetic radiation onto said detection means, wherein said first optical path and said second optical path share a coaxial optical path section.
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Abstract
The present invention provides a multi-spectral optical, open-field detection system utilizing light-induced-fluorescence imaging and point spectroscopy for use in in-situ diagnosis and treatment of diseased tissue with reduced sensitivity to changes in light source-target-detector geometry. The light excitation and detection optics share a common coaxial optical path which makes the present system very robust to changes in illumination-target-detector geometry. The apparatus may be used for the detection and localization of tumors or other pathological tissues both prior to treatment and for the detection of residual diseases during or after surgery or other treatments to remove or destroy the diseased tissue.
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Citations
39 Claims
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1. An optical device for illuminating a target area and detecting electromagnetic radiation reflected or emitted by fluorescence from said target area, comprising:
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a light source and filter means for transmitting selected wavelengths of electromagnetic radiation emitted from said light source;
a housing including first optical focusing means for shaping and directing a first light beam containing said selected wavelengths along a first optical path and focusing said light beam onto a selected surface area of a target area located a selected distance from said housing;
a detection means for detecting light; and
said housing including second optical focusing means for shaping and directing electromagnetic radiation reflected or emitted from said target area as a second light beam along a second optical path and focusing said electromagnetic radiation onto said detection means, wherein said first optical path and said second optical path share a coaxial optical path section. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A multi-spectral fluorescence imaging and spectroscopic apparatus for fluorescence imaging and spectroscopy, comprising:
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a light source and filter means for transmitting selected wavelengths of electromagnetic radiation emitted from said light source, a housing and positioning means for positioning said housing in preselected positions, said housing including a first optical focusing means for shaping and directing a first light beam containing said selected wavelengths along a first optical path and focusing said light beam onto a selected surface area of a target area located a selected distance from said housing;
detection means including a first light detector and a spectrometer; and
said housing including second optical focusing means for shaping and directing electromagnetic radiation reflected or emitted from said target area as a second light beam along a second optical path and focusing said electromagnetic radiation onto said detection means, wherein said first optical path and said second optical path share a coaxial optical path section, said second optical focussing means including means for splitting said second light beam into a third light beam and directing said third light beam toward said spectrometer and a fourth light beam directed toward, and imaged onto, said first light detector for producing an image of the target area from which light is diffusely reflected and/or emitted by fluorescence. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method for illuminating a target area and detecting electromagnetic radiation reflected or emitted by fluorescence from the target area, comprising the steps of;
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shaping and directing a first light beam containing selected wavelengths along a first optical path and focusing said light beam onto a selected surface area of a target area; and
shaping and directing electromagnetic radiation reflected or emitted from said target area as a second light beam along a second optical path and focusing said electromagnetic radiation as an image onto a light detection means, wherein said first optical path and said second optical path share a common coaxial optical path section so that only the region of the target area where diffusely reflected light or light emitted by fluorescence are being detected is being illuminated by said first light beam; and
d) processing signals output from said light detection means and displaying the processed signals in a selected format. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification