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Hybrid electrical device with biological components

  • US 20020050611A1
  • Filed: 08/22/2001
  • Published: 05/02/2002
  • Est. Priority Date: 02/22/1999
  • Status: Active Grant
First Claim
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1. An electrical junction between one transistor and at least one voltage-sensitive cell (VSC) characterized by at least one of the features selected from the group consisting of:

  • (i) voltage transfer between the transistor and the VSC is bi-directional, the transistor being a floating gate depletion type device, the VSC being associated with the floating gate and being capable of being stimulated by a voltage pulse applied to the source, channel and drain of the transistor;

    (ii) there is no DC bias between the transistor and the solution containing the VSC, the transistor being a depletion type device;

    (iii) the VSC is anchored to the external surface of the transistor by binding moieties, optionally through spacers;

    (iv) the voltage transfer between the membrane of the VSC and the external surface of the transistor, and between the external surface of the transistor and the membrane of the VSC is mediated by hyper-polarizable chromophores;

    (v) a combination of two or more of the features of (i) to (iv).

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