Compositions and methods for therapuetic agents complexed with calcium phosphate and encased by casein
First Claim
1. A particle, comprising:
- (1) a core, comprising calcium phosphate;
(2) a therapeutic agent associated with the core; and
(3) a layer comprising casein at least partially covering the core.
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates generally to an oral drug delivery system which incorporates a therapeutic bioactive agent with biodegradable calcium phosphate particles, the particles then encapsulated by casein. The resulting particles provide a carrier designed to protect the therapeutic agent in the harsh, acidic environment of the stomach before releasing the agent into the small intestine. The therapeutic agent may be any therapeutically effective agent, such as a natural isolate or synthetic chemical or biological agent, such as a therapeutic agent, and in particular, may be a protein or a peptide such as insulin. Also incorporated with the particles may be additional surface modifying agents to assist binding, controlled release, or to otherwise modify the particles. The particles generally support the therapeutic agent to form controlled- or sustained-release particles for the oral or mucosal delivery of the therapeutic agent over time, wherein the therapeutic agent is incorporated into the structure of the particle core, disposed on the surface of the particle, or both.
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Citations
12 Claims
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1. A particle, comprising:
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(1) a core, comprising calcium phosphate;
(2) a therapeutic agent associated with the core; and
(3) a layer comprising casein at least partially covering the core. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 12)
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9. A therapeutic composition suitable for oral delivery of insulin, comprising:
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(1) a core comprising calcium phosphate;
(2) insulin and polyethylene glycol associated with the core;
wherein the insulin and polyethylene glycol are at least partially encapsulated within the core;
(3) a capsule comprising casein at least partially covering the core;
wherein the capsule is combined with a pharmaceutically acceptable excipient.
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10. A method of preparing one or more particles having calcium phosphate complexed with a therapeutic agent to form a particle, wherein the particle is encapsulated by casein, comprising:
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(a) reacting a soluble calcium salt, a soluble phosphate salt, and the therapeutic agent to form a mixture;
(b) dispersing the mixture in a solution of casein. - View Dependent Claims (11)
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Specification