Method and system for diagnosing and treating thalamocortical dysrhythmia
First Claim
1. A method for diagnosing thalamacortical dysrhythmia, comprising the following steps:
- measuring electromagnetic activity of a cortical brain region;
determining the spectral content of the electromagnetic activity of the cortical brain region; and
determining whether the spectral content includes an increase in either signal level of the electromagnetic activity or a ratio of theta-band to gamma-band oscillations, relative to a reference level.
1 Assignment
0 Petitions
Accused Products
Abstract
Method and system for diagnosing and treating thalamocortical dysrhythmia. Thalamocortical dysrhythmia occurs when unbalanced neural activity occurs due to the rise of low frequency (approximately 4-8 Hz) and high frequency (approximately 20-50 Hz) neuronal oscillation activity simultaneously within awake individuals. The underlying mechanism that causes thalamocortical dysrhythmia is abnormal input into thalamic cells, which causes a low-frequency shift, increased amplitude, and increased frequency correlation of neuronal oscillation at the cortical and thalamic levels. The present invention measures the neuronal activity at the cortical level, filters these measurements, and performs a Fourier transform to transfer neuronal oscillation data into the frequency domain. The present invention then selects at least one reference baseline based on the characteristics of control subjects that do not have thalamocortical dysrhythmia and/or patients that have thalamocortical dysrhythmia. The present invention determines the amplitude, frequency, and correlation deviations of the measured neuronal oscillations relative to the selected baselines and then determines whether an individual has thalamocortical dysrhythmia based on the deviations from the selected baselines. The present invention is thereby able to diagnose individuals as having or not having thalamocortical dysrhythmia, as well as to prescribe treatment for thalamocortical dysrhythmia based on the diagnosis and underlying amplitude, frequency and correlation deviation measurements.
-
Citations
37 Claims
-
1. A method for diagnosing thalamacortical dysrhythmia, comprising the following steps:
-
measuring electromagnetic activity of a cortical brain region;
determining the spectral content of the electromagnetic activity of the cortical brain region; and
determining whether the spectral content includes an increase in either signal level of the electromagnetic activity or a ratio of theta-band to gamma-band oscillations, relative to a reference level. - View Dependent Claims (5, 6, 7, 10, 11, 15, 18, 19, 20, 27, 31, 32, 33, 34, 35, 36, 37)
-
-
2. A method for diagnosing thalamacortical dysrhythmia, comprising the following steps:
-
measuring electromagnetic activity of a cortical brain region;
determining the spectral content of the electromagnetic activity of the cortical brain region; and
determining whether the spectral content includes a shift in neuronal oscillation to a lower frequency range relative to a reference level. - View Dependent Claims (12, 13, 16, 21, 22, 23, 28)
-
-
3. A method for diagnosing thalamacortical dysrhythmia, comprising the following steps:
-
measuring electromagnetic activity of a cortical brain region at a plurality of different points in time;
determining the spectral content of the electromagnetic activity of the cortical brain region at each point in time; and
determining whether the spectral content includes a coherence between low frequency range oscillations and high frequency range oscillations. - View Dependent Claims (4, 8, 9, 14, 17, 24, 25, 26, 29)
-
-
30. A method for diagnosing thalamocortical dysrhythmia, said method comprising the steps of:
-
measuring neuronal oscillations, filtering said neuronal oscillations, transforming said filtered neuronal oscillations into the frequency domain, cross-correlating said frequency domain neuronal oscillation measurements, selecting at least one baseline as a reference with which to compare at least one of said frequency domain neuronal oscillation measurements and said cross-correlated neuronal oscillation measurements, determining the deviation of at least one of said frequency domain neuronal oscillation measurements and said cross-correlated neuronal oscillation measurements from at least one of said baselines; and
determining if thalamocortical dysrhythmia is present based on at least one of said deviation determinations.
-
Specification