Method and system for diagnosing and treating thalamocortical dysrhythmia

• US 20020055675A1
• Filed: 06/07/2001
• Published: 05/09/2002
• Est. Priority Date: 06/07/2000
• Status: Active Grant

• Current Assignee: New York University
• Original Assignee: New York University
• Inventors: Ribary, Urs, Llinas, Rodolfo, Jeanmonod, Daniel
• Granted Patent: US 6,687,525 B2
• Time in Patent Office: Days
• US Class Current: 600/407
• CPC Class Codes: A61B 5/245 specially adapted for magnetoencephalographic [MEG] signals
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition
• CPC Class Codes: A61B 5/7253 characterised by using transforms
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

Method and system for diagnosing and treating thalamocortical dysrhythmia. Thalamocortical dysrhythmia occurs when unbalanced neural activity occurs due to the rise of low frequency (approximately 4-8 Hz) and high frequency (approximately 20-50 Hz) neuronal oscillation activity simultaneously within awake individuals. The underlying mechanism that causes thalamocortical dysrhythmia is abnormal input into thalamic cells, which causes a low-frequency shift, increased amplitude, and increased frequency correlation of neuronal oscillation at the cortical and thalamic levels. The present invention measures the neuronal activity at the cortical level, filters these measurements, and performs a Fourier transform to transfer neuronal oscillation data into the frequency domain. The present invention then selects at least one reference baseline based on the characteristics of control subjects that do not have thalamocortical dysrhythmia and/or patients that have thalamocortical dysrhythmia. The present invention determines the amplitude, frequency, and correlation deviations of the measured neuronal oscillations relative to the selected baselines and then determines whether an individual has thalamocortical dysrhythmia based on the deviations from the selected baselines. The present invention is thereby able to diagnose individuals as having or not having thalamocortical dysrhythmia, as well as to prescribe treatment for thalamocortical dysrhythmia based on the diagnosis and underlying amplitude, frequency and correlation deviation measurements.

Claims

1. A method for diagnosing thalamacortical dysrhythmia, comprising the following steps:

measuring electromagnetic activity of a cortical brain region;

determining the spectral content of the electromagnetic activity of the cortical brain region; and

determining whether the spectral content includes an increase in either signal level of the electromagnetic activity or a ratio of theta-band to gamma-band oscillations, relative to a reference level.

5. The method of claim 1, further comprising the steps of removing cardiac artifacts and external noise.

6. The method of claim 1, further comprising the step of utilizing a magnetoencepholograph to perform the measuring step.

7. The method of claim 1, further comprising the step of utilizing a PET device to perform the measuring step.

10. The method of claim 1, wherein the reference level corresponds to a subject'"'"'s own level without the presence of the dysrhythmia.

11. The method of claim 1, wherein the reference level corresponds to a level without the presence of the dysrhythmia as obtained from one or more different individuals.

15. The method of claim 1, wherein the step of determining whether the spectral content includes an increase in either signal level of the electromagnetic activity or a ratio of theta-band to gamma-band oscillations, is indicative of an abnormal input to a thalamic brain portion, which in turn causes neuronal hyperpolarization, which results in thalamic oscillations at a theta-band frequency range, the thalamic oscillations in turn causing theta-band frequency range oscillations in the cortical brain region via corticothalamic pathways.

18. The method of claim 1, wherein an abnormal input is provided to a thalamic brain portion.

19. The method of claim 1, wherein thalamic oscillations occur at a theta-band frequency.

20. The method of claim 1, wherein theta-band frequency oscillations occur in the cortical brain region.

27. The method of claim 1, wherein a reduction of lateral inhibition in a first portion of the brain promotes coherent gamma-band oscillations in a different portion of the brain.

31. The method of claim 1, wherein said neuronal oscillations are measured at the cortical level.

32. The method of claim 1, wherein said neuronal oscillation measurements are filtered to remove cardiac artifacts and external noise artifacts.

33. The method of claim 1, wherein said baseline references include the neuronal oscillation characteristics of at least one individual without thalamocortical dysrhythmia.

34. The method of claim 1, wherein said baseline references include the neuronal oscillation characteristics of at least one individual with thalamocortical dysrhythmia.

35. The method of claim 1, wherein at least one baseline reference is a threshold that acts as a threshold value relative to said neuronal oscillation measurements.

36. The method of claim 1, wherein at least two of said deviations from said baselines are determined, and wherein said deviations from said baselines are then weighted and summed to determine if thalamocortical dysrhythmia is present.

37. The method of claim 1, including the step of treating individuals determined to have thalamocortical dysrhythmia, and wherein said treatment may include at least one of the treatment methods including surgery, electrostimulation, and pharmacological treatment.

2. A method for diagnosing thalamacortical dysrhythmia, comprising the following steps:

measuring electromagnetic activity of a cortical brain region;

determining the spectral content of the electromagnetic activity of the cortical brain region; and

determining whether the spectral content includes a shift in neuronal oscillation to a lower frequency range relative to a reference level.

12. The method of claim 2, further comprising the additional step of providing treatment for the dysrhythmia in the form of at least one of:

surgical treatment, electrical treatment, and pharmacological treatment.

13. The method of claim 2, comprising the additional step of determining the dysrhythmia to be at least one of:

neurogenic pain, obsessive compulsive disorder, depression, panic disorder, Parkinson'"'"'s disease, schizophrenia, rigidity, dystonia, tinnitus, and epilepsy.

16. The method of claim 2, wherein the step of determining whether the spectral content includes a shift in neuronal oscillation to a lower frequency range relative to a reference level is indicative of an abnormal input to a thalamic brain portion, which in turn causes neuronal hyperpolarization, which results in thalamic oscillations at a theta-band frequency range, the thalamic oscillations in turn causing theta-band frequency range oscillations in the cortical brain region via corticothalamic pathways.

21. The method of claim 2, wherein an abnormal input is provided to a thalamic brain portion.

22. The method of claim 2, wherein thalamic oscillations occur at a theta-band frequency.

23. The method of claim 2, wherein theta-band frequency oscillations occur in the cortical brain region.

28. The method of claim 2, wherein a reduction of lateral inhibition in a first portion of the brain promotes coherent gamma-band oscillations in a different portion of the brain.

3. A method for diagnosing thalamacortical dysrhythmia, comprising the following steps:

measuring electromagnetic activity of a cortical brain region at a plurality of different points in time;

determining the spectral content of the electromagnetic activity of the cortical brain region at each point in time; and

determining whether the spectral content includes a coherence between low frequency range oscillations and high frequency range oscillations.

4. The method of claim 3 wherein the low frequency range includes the theta-band and the high frequency range includes the gamma-band.

8. The method of claim 3, wherein the step of determining whether the spectral content includes a coherence between low frequency range oscillations and high frequency range oscillations includes the step of generating a frequency-frequency plot.

9. The method of claim 3, wherein the measuring step is carried out at a plurality of different cortical regions, further comprising the additional step of identifying at least one specific cortical region where a sysrhythmia is present.

14. The method of claim 3, comprising the additional step of determining the dysrhythmia to be at least one of:

neurogenic pain, obsessive compulsive disorder, depression, panic disorder, Parkinson'"'"'s disease, schizophrenia, rigidity, dystonia, tinnitus, and epilepsy.

17. The method of claim 3, wherein the step of determining whether the spectral content includes a coherence between low frequency range oscillations and high frequency range oscillations is indicative of an abnormal input to a thalamic brain portion, which in turn causes neuronal hyperpolarization, which results in thalamic oscillations at a theta-band frequency range, the thalamic oscillations in turn causing theta-band frequency range oscillations in the cortical brain region via corticothalamic pathways.

24. The method of claim 3, wherein an abnormal input is provided to a thalamic brain portion.

25. The method of claim 3, wherein thalamic oscillations occur at a theta-band frequency.

26. The method of claim 3, wherein theta-band frequency oscillations occur in the cortical brain region.

29. The method of claim 3, wherein a reduction of lateral inhibition in a first portion of the brain promotes coherent gamma-band oscillations in a different portion of the brain.

30. A method for diagnosing thalamocortical dysrhythmia, said method comprising the steps of:

measuring neuronal oscillations,

filtering said neuronal oscillations,

transforming said filtered neuronal oscillations into the frequency domain,

cross-correlating said frequency domain neuronal oscillation measurements,

selecting at least one baseline as a reference with which to compare at least one of said frequency domain neuronal oscillation measurements and said cross-correlated neuronal oscillation measurements,

determining the deviation of at least one of said frequency domain neuronal oscillation measurements and said cross-correlated neuronal oscillation measurements from at least one of said baselines; and

determining if thalamocortical dysrhythmia is present based on at least one of said deviation determinations.