ULTRASOUND-MEDIATED DRUG DELIVERY
First Claim
1. A device for transdermal administration of topical therapeutic agents, comprising an applicator for applying an effective amount of a therapeutic agent to a tissue surface of a subject;
- and an ultrasound transducer, operatively coupled to the applicator, for providing ultrasound energy to the tissue surface at at least one predetermined frequency to promote transdermal absorption of the drug through the tissue of the subject.
2 Assignments
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Accused Products
Abstract
Methods and apparatus are disclosed for treating physiological problems, and for providing rapid, efficacious transdermal treatment, for example, of muscle sprains, erectile dysfunction, or baldness, without requiring the use of needles or other invasive interventions. A topical therapeutic agent and ultrasound energy are applied to a tissue surface, e.g., the skin, such that the ultrasound enhances transdermal penetration of the agent. The invention is especially useful in localized delivery of a controlled dosage of a therapeutic agent to the small blood vessels and capillaries beneath the skin'"'"'s surface.
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Citations
50 Claims
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1. A device for transdermal administration of topical therapeutic agents, comprising
an applicator for applying an effective amount of a therapeutic agent to a tissue surface of a subject; - and
an ultrasound transducer, operatively coupled to the applicator, for providing ultrasound energy to the tissue surface at at least one predetermined frequency to promote transdermal absorption of the drug through the tissue of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for treating erectile dysfunction, the method comprising:
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contacting a tissue surface of a male subject in need of such treatment with an effective amount of an agent capable of capable of treating erectile dysfunction; and
applying ultrasound energy to the tissue surface, such that the erectile dysfunction is treated. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method for treating muscle inflammation, the method comprising:
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contacting a tissue surface overlying an inflamed muscle region with an effective amount of an agent capable of capable of treating muscle inflammation; and
applying ultrasound energy to the tissue surface, such that the agent is transported transdermally to the muscle tissue and the inflammation is treated. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A method for treating hair loss comprising:
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contacting a tissue surface of a subject in need of such treatment with an effective amount of an agent capable of inhibiting hair loss; and
applying ultrasound energy to the tissue surface, such that the agent is transported transdermally to a subdermal region proximal to a dormant hair follicle papilla stimulate activity of the dormant papilla. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50)
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Specification