Stent with smooth ends

• US 20020055769A1
• Filed: 12/14/2001
• Published: 05/09/2002
• Est. Priority Date: 05/05/1998
• Status: Active Grant

• Current Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Wang, Lixiao
• Granted Patent: US 6,652,575 B2
• Time in Patent Office: Days
• US Class Current: 623/1.13
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/92 Stents in the form of a rolled-up sheet expanding after insertion into the vessel , e.g. with a spiral shape in cross-section
• CPC Class Codes: A61F 2002/91541 Adjacent bands are arranged out of phase
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2250/0018 differing in elasticity, stiffness or compressibility
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 2300/25 Peptides having up to 20 amino acids in a defined sequence
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

A stent having at least one smooth end is disclosed. The stent may include a coating or coatings on one or both end portions to provide a smooth finish to reduce possible damage to body passages when the stent is deployed and delivered. The stent may also contain drugs or surgical adhesives or a combination thereof in or on the coated portion of the stent. The stent may also be of the type where the materials of the stent may be treated to have a smooth flexible end or ends. The stent may also be of a configuration such that at least one end is more flexible than the middle portion of the stent.

Claims

1. An expandable intraluminal stent comprising a main body portion having a first end portion, a second end portion, a middle portion and a flow passage defined therethrough, at least a portion of the first end portion having a biocompatible coating.

2. The stent of claim 1 wherein the coating comprises a biocompatible polymer.

3. The stent of claim 1 wherein the coating comprises a biodegradable polymer.

4. The stent of claim 1 wherein the first end portion comprises an inner surface, an outer surface, an end and an edge, the coating covering the end and at least a portion of the edge of the first end portion.

5. The stent of claim 1 wherein at least a portion of the second end portion has a biocompatible coating.

6. The stent of claim 5 wherein the second end portion comprises an outer surface, an inner surface, an end, and an edge, the coating covering the end and at least a portion of the edge of the second end portion.

7. The stent of claim 5 wherein the coating comprises a biocompatible polymer.

8. The stent of claim 1 wherein the coating includes a drug.

9. The stent of claim 8 wherein the drug comprises TAXOL.

10. The stent of claim 1 wherein the coating includes a bioadhesive.

11. The stent of claim 1 wherein the coating comprises a plurality of layers.

12. The stent of claim 11 wherein the plurality of layers is comprised of the same coating material.

13. The stent of claim 11 wherein the plurality of layers is comprised of different coating materials.

14. The stent of claim 12 wherein at least one of the layers includes a drug.

15. The stent of claim 5 wherein the coating comprises a plurality of layers.

16. The stent of claim 15 wherein the plurality of layers is comprised of the same coating material.

17. The stent of claim 15 wherein the plurality of layers is comprised of different materials.

18. The stent of claim 15 wherein at least one of the layers includes a drug.

20. The stent of claim 19 wherein the sleeve comprises a biocompatible polymer.

21. The stent of claim 19 wherein the coating comprises a biodegradable polymer.

22. The stent of claim 19 wherein the sleeve includes apertures.

23. The stent of claim 19 wherein the sleeve includes a drug.

24. The stent of claim 23 wherein the drug comprises TAXOL.

25. The stent of claim 19 wherein the sleeve comprises a plurality of layers.

26. The stent of claim 25 wherein the plurality of layers is comprised of the same coating material.

27. The stent of claim 25 wherein the plurality of layers is comprised of different materials.

28. The stent of claim 25 wherein at least one of the layers includes a drug.

29. The stent of claim 19 further comprising a second sleeve connected to the second end portion.

30. The stent of claim 29 wherein the sleeve comprises a biocompatible polymer.

31. The stent of claim 29 wherein the sleeve includes apertures.

32. The stent of claim 29 wherein the sleeve includes a drug.

33. The stent of claim 29 wherein the sleeve comprises a plurality of layers.

34. The stent of claim 33 wherein the plurality of layers is comprised of the same coating material.

35. The stent of claim 33 wherein the plurality of layers is comprised of different materials.

36. The stent of claim 33 wherein at least one of the layers includes a drug.

38. The stent of claim 37 further comprising a polished second end portion to provide a smooth second end portion.

40. The stent of claim 39 further comprising a heat treated second end portion to provide flexibility.

45. The stent of claim 1 wherein the coating comprises an RGD peptide-containing compound.

46. The stent of claim 8 wherein the drug comprises 5-firoracil.

47. The stent of claim 8 wherein the drug comprises Tranilast.

48. The stent of claim 8 wherein the drug comprises Tropidil.

49. The stent of claim 8 wehrien the drug comprises Probucol.

19. An expandable intraluminal stent comprising a main body portion having a first end portion, a second end portion, a middle portion and a flow passage defined therethrough, and a sleeve of biocompatible material connected to the first end portion.

37. An expandable intraluminal stent comprising a main body portion having a first end portion, a second end portion, a middle portion and a flow passage defined therethrough, the first end portion being polished to provide a smooth first end portion.

39. An expandable intraluminal stent comprising a main body portion having a first end portion, a second end portion, a middle portion and a flow passage defined therethrough, the first end portion being heat treated to provide flexibility.

41. An expandable intraluminal stent comprising a main body portion having a first end portion, a second end portion, a middle portion and a flow passage defined therethrough, the first end portion constructed in a manner so as to be more flexible than the middle portion.

42. The stent of claim 41 wherein the stent comprises a looser mesh first end portion than the middle portion.

43. The stent of claim 41 further comprising the second end portion constructed in a manner so as to be more flexible than the middle portion.

44. The stent of claim 43 wherein the stent comprises a looser mesh second end portion than the middle portion.