Stromal cell use

• US 20020058025A1
• Filed: 04/20/2001
• Published: 05/16/2002
• Est. Priority Date: 10/26/1998
• Status: Abandoned Application

• Current Assignee: Philadelphia Health and Education Corp (Drexel University)
• Original Assignee: Philadelphia Health and Education Corp (Drexel University)
• Inventors: Prockop, Darwin J., Langell, John, Reiss, Russell G.
• Application Number:
  US09/839,711
• Publication Number:
  US 20020058025A1
• Time in Patent Office: Days
• US Class Current: 424/93.71
• CPC Class Codes: A61K 35/28 Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• CPC Class Codes: A61P 39/00 General protective or antinoxious agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid

Abstract

The invention relates to the use of marrow stromal cells to enhance hematopoiesis in a mammal.

Claims

1. A method of rescuing a mammal from a lethal dose of total body irradiation, said method comprising administering marrow stromal cells from an allogenic but otherwise identical donor mammal to an irradiated mammal, thereby rescuing said mammal from a lethal dose of total body irradiation.

2. The method of claim 1, wherein said mammal is selected from the group consisting of a rodent, a horse, a cow, a pig, a dog, a cat, a non-human primate, and a human.

3. The method of claim 2, wherein said mammal is a human.

4. The method of claim 1, wherein said administration is infusion.

5. A method of enhancing hematopoiesis in a mammal, said method comprising administering marrow stromal cells from an allogenic but otherwise identical donor mammal to a mammal, thereby enhancing hematopoiesis in said mammal.

6. The method of claim 5, wherein said mammal is selected from the group consisting of a rodent, a horse, a cow, a pig, a dog, a cat, a non-human primate, and a human.

7. The method of claim 6, wherein said mammal is a human.

8. The method of claim 5, wherein said administration is infusion.

9. A method of enhancing hematopoietic stem cell differentiation in a mammal given a lethal dose of total body irradiation, said method comprising administering marrow stromal cells from an allogenic but otherwise identical donor mammal to an irradiated mammal, thereby enhancing hematopoietic stem cell differentiation in said mammal.

10. The method of claim 9, wherein said mammal is selected from the group consisting of a rodent, a horse, a cow, a pig, a dog, a cat, a non-human primate, and a human.

11. The method of claim 10, wherein said mammal is a human.

12. The method of claim 9, wherein said administration is infusion.

13. A method of enhancing the hematopoietic recovery in a mammal given a lethal dose of total body irradiation, said method comprising administering marrow stromal cells from an allogenic but otherwise identical donor mammal to an irradiated mammal, thereby enhancing the hematopoietic recovery in said mammal.

14. A method of treating a mammal comprising an ablated marrow, said method comprising administering marrow stromal cells from an allogenic but otherwise identical donor mammal to a mammal, thereby treating said mammal comprising an ablated marrow.

15. A method of enhancing hematopoiesis in a mammal comprising an ablated marrow, said method comprising administering marrow stromal cells from an allogenic but otherwise identical donor mammal to a mammal, thereby enhancing hematopoiesis in said mammal comprising an ablated marrow.

16. A method of increasing survival of a mammal exposed to a lethal dose of total body irradiation, said method comprising administering marrow stromal cells from an allogenic but otherwise identical donor mammal to an irradiated mammal, thereby increasing the survival of a mammal exposed to a lethal dose of total body irradiation.