Enterotoxin adsorbent, method of adsorptive removal, and adsorption apparatus

• US 20020058032A1
• Filed: 09/25/2001
• Published: 05/16/2002
• Est. Priority Date: 09/26/2000
• Status: Active Grant

• Current Assignee: Kaneka Corporation
• Original Assignee: Kaneka Corporation
• Inventors: Hirai, Fumiyasu, Fujimoto, Tamiji, Furuyoshi, Shigeo
• Granted Patent: US 6,969,616 B2
• Time in Patent Office: Days
• US Class Current: 424/140.1
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 2202/0014 removed from the body
• CPC Class Codes: A61M 2202/0445 Proteins
• CPC Class Codes: B01D 15/00 Separating processes involving the treatment of liquids with solid sorbents using liquid sorbents B01D11/00; ion exchange processes or materials, sorbent materials in general B01J, e.g. sorbents for chromatography B01J20/281; for investigating or analysing materials G01N30/00; Apparatus therefor
• CPC Class Codes: B01J 20/28078 Pore diameter
• CPC Class Codes: B01J 20/3092 Packing of a container, e.g. packing a cartridge or column of chromatography columns B01D15/206
• CPC Class Codes: B01J 20/3212 consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3217 Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
• CPC Class Codes: B01J 20/3219 involving a particular spacer or linking group, e.g. for attaching an active group
• CPC Class Codes: B01J 20/3242 Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
• CPC Class Codes: B01J 20/3248 the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
• CPC Class Codes: B01J 20/3255 comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
• CPC Class Codes: B01J 2220/58 Use in a single column
• CPC Class Codes: C07K 14/31 from Staphylococcus (G)

Abstract

The present invention is directed to an enterotoxin adsorbent comprising a compound having a log P (P denotes a partition coefficient in an octanol-water system) value of not less than 2.50 as immobilized on a water-insoluble carrier.

Claims

1. An enterotoxin adsorbent comprising a compound with a log P, in which P represents a partition coefficient in an octanol-water system, value of not less than 2.50 as immobilized on a water-insoluble carrier.

2. The adsorbent according to claim 1

wherein said water-insoluble carrier is a water-insoluble porous carrier.

3. The adsorbent according to claim 2

wherein said water-insoluble porous carrier has a molecular weight of exclusion limit of 5000 to 600000 for globular protein.

4. A method for adsorptive removal of an enterotoxin in a body fluid

which comprises contacting an enterotoxin-containing body fluid with the adsorbent according to claim 1.

5. An enterotoxin adsorption apparatus wherein a housing has an inlet and an outlet for a body fluid as well as a means for precluding flowing out of an adsorbent therefrom, and is packed therein the adsorbent according to claim 1.