Synthesis of epothilones, intermediates thereto and analogues thereof
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Abstract
The present invention provides convergent processes for preparing epothilones, desoxyepothilones, and analogues thereof. The present invention further provides novel compositions and methods for the treatment of cancer and additionally provides methods for the treatment of cancer which has developed a multi-drug phenotype.
150 Citations
63 Claims
- 1. A compound having the structure:
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36. A method of preparing a compound having the structure:
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39. A method of preparing a compound having the structure:
- 41. A method of preparing a compound having the structure:
- 44. A method of preparing a compound having the structure:
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47. A method of preparing a compound having the structure:
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48. A method for preparing a compound having the structure:
- 53. A method for preparing a compound having the structure:
Specification