Reduction of spectral site to site variation
First Claim
1. A method of minimizing error in optic spectra from a sample comprising the steps of:
- applying one or more fixed fiducial points to the sample surface; and
referencing an optical probe to said one or more fiducial points, so that the spectra are taken in the same place.
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Accused Products
Abstract
The invention relates to devices and methods that improve the quality of optic measurements from surfaces such as skin and biological materials. Three methods for reducing spectral site to site variation in fluorescence and/or reflectance signals obtained from a sample surface are: repeated measurements taken at identifiable location(s) determined by fiducial marks, repeat of measurements at different locations on the sample, and tensioning the sample surface during measurement to alleviate surface heterogeneity. Combinations of these methodologies provide best results, and are expected to improve the ability to measure blood glucose non-invasively.
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Citations
29 Claims
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1. A method of minimizing error in optic spectra from a sample comprising the steps of:
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applying one or more fixed fiducial points to the sample surface; and
referencing an optical probe to said one or more fiducial points, so that the spectra are taken in the same place. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of minimizing the variation of optic spectra from a sample comprising the steps of:
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gathering a plurality of spectra at nearby points on the sample; and
combining the spectra so as to form a representative measurement. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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- 20. A method of minimizing the variation of measured optic spectra from a flexible sample surface comprising tensioning the sample surface prior to or at the time of making a spectral measurement with an optical probe.
Specification