Method for measuring baroreflex sensitivity and therapy optimization in heart failure patients
First Claim
1. A method for measuring baroreflex sensitivity, comprising:
- pacing a heart for a plurality of paced heart beats, wherein the plurality of paced beats comprise a pacing series and each of the pacing series are followed by a plurality of intrinsic heart beats, wherein the plurality of intrinsic heart beats comprise an intrinsic series measuring a change in pulse pressure during the pacing series;
measuring a change in intrinsic cycle length resulting from the change in pulse pressure during the pacing series; and
calculating baroreflex sensitivity from the change in pulse pressure measurements and the change in intrinsic cycle length measurements after a plurality of pacing series.
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Abstract
A method and apparatus for determining the baroreflex sensitivity in a chronic heart failure patient and a method for chronic heart therapy evaluation. The method including providing a series of pacing stimuli to the heart of a chronic heart failure patient and measuring the change in pulse pressure and the change in cycle length incident to each pacing series. The changes being plotted to produce a line indicative of baroreflex sensitivity. The apparatus including a pacemaker having sensors for monitoring both cycle length and pulse pressure wherein the sensors may be integral or separate from the pacemaker. The method for evaluating chronic heart failure therapies including administering a series of therapies and evaluating each therapy based on the resultant increase of the patient'"'"'s baroreflex sensitivity.
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Citations
21 Claims
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1. A method for measuring baroreflex sensitivity, comprising:
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pacing a heart for a plurality of paced heart beats, wherein the plurality of paced beats comprise a pacing series and each of the pacing series are followed by a plurality of intrinsic heart beats, wherein the plurality of intrinsic heart beats comprise an intrinsic series measuring a change in pulse pressure during the pacing series;
measuring a change in intrinsic cycle length resulting from the change in pulse pressure during the pacing series; and
calculating baroreflex sensitivity from the change in pulse pressure measurements and the change in intrinsic cycle length measurements after a plurality of pacing series. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for measuring baroreflex sensitivity, comprising:
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a step for pacing a heart for a plurality of paced heart beats, wherein the plurality of paced beats comprise a pacing series and each of the pacing series are followed by a plurality of intrinsic heart beats, wherein the plurality of intrinsic heart beats comprise an intrinsic series;
a step for determining a change in pulse pressure during the pacing series;
a step for determining a change in intrinsic cycle length resulting from the change in pulse pressure; and
a step for determing baroreflex sensitivity based on the change of cycle length divided by the change in pulse pressure. - View Dependent Claims (9)
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10. An apparatus for measuring baroreflex sensitivity, comprising:
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a pacemaker having at least one variable parameter capable of altering a pulse pressure in a patient;
a first sensor for sensing a cycle length in a heart; and
a second sensor for sensing the pulse pressure in the patient. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. An apparatus for measuring baroreflex sensitivity, comprising:
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a means for altering a pulse pressure in a patient;
a means for sensing a cycle length in a heart; and
a means for sensing the pulse pressure in the patient.
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20. A method for evaluating a cardiac rehabilitative therapy, comprising:
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measuring baroreflex sensitivity before the cardiac rehabilitative therapy;
providing a cardiac rehabilitative therapy to the CHF patient;
measuring baroreflex sensitivity after the cardiac rehabilitative therapy; and
evaluating results of the rehabilitative therapy based on a comparison of a first measurement of baroreflex sensitivity before the cardiac rehabilitative therapy and a second measurement of baroreflex sensitivity after the cardiac rehabilitative therapy.
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21. A method for evaluating a cardiac rehabilitative therapy, comprising:
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a step for measuring baroreflex sensitivity before the cardiac rehabilitative therapy;
a step for providing a cardiac rehabilitative therapy to the CHF patient;
a step for measuring baroreflex sensitivity after the step of providing cardiac rehabilitative therapy; and
a step for evaluating results of the rehabilitative therapy based on a comparison of a first measurement of baroreflex sensitivity before the cardiac rehabilitative therapy and a second measurement of baroreflex sensitivity after the cardiac rehabilitative therapy.
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Specification